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Now showing items 2035-2054 of 10152
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Dermal Application of Chloramphenicol - The Effect of Liposomes and Chitosan Hydrogel Formulations on ex vivo Permeation and Antimicrobial Activity
(Conference object; Konferansebidrag, 2017)Liposomes solubilize lipophilic drugs in the phospholipid membrane, and entrap hydrophilic drugs in its aqueous core. These vesicles provide a sustained- and targeted- drug release, and protect from degradation. Liposomes retain the drug onto/in the skin and improve skin drug deposition. Due to their liquid nature, a secondary vehicle, such as a hydrogel, is needed to obtain a necessary retention ... -
Description of health-related rehabilitation service provision and delivery in randomized controlled trials: A topic review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-18)Objective: To determine how health-related rehabilitation services have been described in recently pub-lished randomized clinical trials, using the International Classification System for Service Organization in Health-Related Rehabilitation (ICSO-R 2.0) as a framework.<p><p> Methods: Medline was searched for English--language randomized clinical trials (RCTs) published between 1 January 2018 and ... -
Description of the prehospital emergency healthcare system in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-23)Background: Norway has a long coastline, steep mountains, and wide fjords, which presents some challenges to the prehospital emergency healthcare system. In recent years, the prehospital emergency medical services (EMS) have undergone significant changes, structurally, in terms of professionalisation of the services and in the education level of the personnel. In this article, we aim to describe ... -
Description of the prehospital emergency healthcare system in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-23)Background: Norway has a long coastline, steep mountains, and wide fjords, which presents some challenges to the prehospital emergency healthcare system. In recent years, the prehospital emergency medical services (EMS) have undergone significant changes, structurally, in terms of professionalisation of the services and in the education level of the personnel. In this article, we aim to describe the ... -
Descriptions of qi deficiency and qi stagnation in traditional East Asian medicine: A comparison of Asian and Western sources
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-20)Introduction - In a previous study, evidence was found of the variability of signs/symptoms (s/s) of blood stasis syndrome among texts of Chinese and Asian origin and English language texts including evidence of the differences between non-Asian and Asian patients. In the current study the diagnostic patterns of qi deficiency (QD) and qi stagnation (QS) were examined to see if similar results could ... -
A descriptive study of ten-year longitudinal changes in weight and waist circumference in the multi-ethnic rural Northern Norway. The SAMINOR Study, 2003-2014
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-19)The obesity epidemic is dynamic with varying secular trends and differences between countries and ethnic groups. The objective of this study was to describe the age- and sex-specific longitudinal changes in weight and waist circumference in a rural Norwegian population with a high proportion of the indigenous Sami population. Based on two population-based surveys, SAMINOR 1 (2003–2004) and SAMINOR ... -
Design and methods in a survey of living conditions in the Arctic–the SLiCA study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012) -
Design and synthesis of novel cyclopentapeptide antagonist for the chemokine receptor CXCR4
(Master thesis; Mastergradsoppgave, 2008-06-16)CXCR4 is a GPCR that by activation of its ligand CXCL12 is involved in the pathology of several diseases, examples being cancer and rheumatoid arthritis. It has also shown to play a crucial role for HIV-1 entry into T-cells and the development of AIDS. Several cyclopentapeptides (CPPs) based on the sequence D-Tyr-Arg-Arg-2-Nal-Gly of the lead compound FC131 have shown to have antagonistic activity. ... -
Design and validity of a questionnaire to assess sexuality in pregnant women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009-07-29)Background: A review of validated methods for assessing female sexual dysfunction and a review of male and female sexual dysfunction did not refer to any specific questionnaire for evaluating sexuality during pregnancy. A study was performed at the Obstetrics and Gynecology Department of Botucatu Medical School, São Paulo State University, Brazil to design and validate a pregnancy sexuality ... -
Design of a location–based Ascom/trixbox prototype for context-sensitive communication system in hospitals
(Master thesis; Mastergradsoppgave, 2010-09-23)This Master thesis is based on an ongoing project work titled ―Context-Sensitive systems for mobile communication in hospitals‖ at Norwegian Centre for Integrated care and Telemedicine (NST), University Hospital of North Norway (UNN). The project group is working on context-sensitive communication in hospitals based on Ascom/trixbox experimental (ATE) platform. The ATE based protocol system ... -
Design of galardine analogs as putative psudolysin inhibitors based on ab initio fragment molecular orbital calculations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-29)Pseudolysin (PLN) is a metalloproteinase secreted from bacteria that degrades extracellular proteins to produce bacterial nutrition. It is thus expected that inhibitors against PLN can suppress the growth of bacteria and their pandemic spread. In addition, since these inhibitors do not attack to bacteria directly, there is a reduced risk for producing drug-resistant bacteria. On the other hand, as ... -
Design of the GutHeart—targeting gut microbiota to treat heart failure—trial: a Phase II, randomized clinical trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-07)<p><i>Aims</i>: Heart failure (HF) is a multifactorial disease. Current treatments target only a fraction of the putative pathophysiological pathways. In patients with HF, reduced cardiac output and congestion cause increased gut wall permeability. It has been suggested that leakage of microbial products is detrimental to the heart, at least partly through activation of systemic inflammatory pathways, ... -
Design og syntese av cyklopentapeptidbaserte CXCR4 antagonister: Variasjon av essensiell aromatisk substituent
(Mastergradsoppgave; Master thesis, 2009-05-20)SAMMENDRAG CXCR4 er en kjemokinreseptor som er involvert i en rekke biologiske prosesser i kroppen, blant annet angiogenese, neurogenese og dannelse av blodceller i embryostadiet. I voksne er CXCR4 funnet å være involvert i sykdommer som HIV, reumatoid artritt og kreft. I litteraturen finnes det potente CXCR4 antagonister (AMD3100, KRH1636, FC131) som har vist effekt mot HIV-1, reumatoid artritt ... -
Design, synthesis and biological evaluation of 6‐substituted quinolines derived from cabozantinib as c‐Met inhibitors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-15)Based on the cabozantinib scaffold, novel c‐Met inhibitors were rationalized from the limited knowledge of structure‐activity relationships for the quinoline 6‐position. Emphasis was given to modifications capable of engaging in additional polar interactions with the c‐Met active site. In addition, <i>ortho</i>‐fluorinations of the terminal benzene ring were explored. Fifteen new molecules were ... -
Design, synthesis and structural studies of relaxin receptor modulators
(Master thesis; Mastergradsoppgave, 2011-06)The relaxin family of peptides consists of seven structurally related peptides, with a wide variety of biological functions, ranging from involvement in reproductive processes to functions as neuroendocrine modulators. Because of the complex, two-chained structure of the relaxins, and their lack of specificity for the various relaxin family receptors (RXFPs), design of simpler, more selective ... -
Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-07-14) -
Designing digital systems for rehabilitation practices
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-22)The trajectories of patients in need of long-term rehabilitation services are extremely complex. Therefore, strengthening the rehabilitation field requires increasing organizational resilience to ensure robust processes and efficient collaboration and communication. In this study, we explored how digital systems can promote organizational resilience in rehabilitation practices. Methodologically, ... -
Designing medical internship to improve recruitment and retention of doctors in rural areas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-18)Background: The medical internship as a way of exposing young doctors to training in a rural context is regarded as a useful tool to recruit and retain doctors in rural areas. Norwegian health authorities tested an arrangement of early sign-up for medical internships in the Finnmark County in Norway.<p> Objective: To report on the effects of the early sign-up for medical internship.<p> Design: ... -
Designing mHealth for maternity services in primary health facilities in a low-income setting - Lessons from a partially successful implementation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-12)<p><i>Background</i>: Increasing mobile phone ownership, functionality and access to mobile-broad band internet services has triggered growing interest to harness the potential of mobile phone technology to improve health services in low-income settings. The present project aimed at designing an mHealth system that assists midlevel health workers to provide better maternal health care services by ... -
Designing national electronic services in the public healthcare sector.
(Doctoral thesis; Doktorgradsavhandling, 2014-12-12)This thesis deals with a socio-technical approach towards the development of inter-organisational ICT tools in healthcare. My overall case is Norwegian healthcare, and I investigated how national inter-organisational ICT tools were developed and why good results were difficult to achieve. Three public projects make up the basis of my data collection in which the main categories of data are interviews, ...
