Browsing Det helsevitenskapelige fakultet by Title

Now showing items 3645-3664 of 10152

    • A fully-coupled fluid-structure interaction simulation of cerebral aneurysms 

      Isaksen, Jørgen Gjernes; Bazilevs, Yuri; Hsu, M. C.; Zhang, Y.; Wang, W.; Liang, X; Kvamsdal, Trond; Brekken, Reidar (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • FuncPEP: A Database of Functional Peptides Encoded by Non-Coding RNAs 

      Dragomir, Mihnea Paul; Manyam, Ganiraju C; Ott, Leonie Florence; Berland, Léa; Knutsen, Erik; Ivan, Cristina; Lipovich, Leonard; Broom, Bradley M.; Calin, George A (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-23)
      Non-coding RNAs (ncRNAs) are essential players in many cellular processes, from normal development to oncogenic transformation. Initially, ncRNAs were defined as transcripts that lacked an open reading frame (ORF). However, multiple lines of evidence suggest that certain ncRNAs encode small peptides of less than 100 amino acids. The sequences encoding these peptides are known as small open reading ...

    • Functional analyses of rare germline BRCA1 variants by transcriptional activation and homologous recombination repair assays 

      Bassi, Nicola; Hovland, Henrikke Nilsen; Rasheed, Kashif; Ghelue, Marijke van (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-21)
      Background - Damaging alterations in the BRCA1 gene have been extensively described as one of the main causes of hereditary breast and ovarian cancer (HBOC). BRCA1 alterations can lead to impaired homologous recombination repair (HRR) of double-stranded DNA breaks, a process which involves the RING, BRCT and coiled-coil domains of the BRCA1 protein. In addition, the BRCA1 protein is involved in ...

    • Functional Analyses of Rare Germline Missense BRCA1 Variants Located within and outside Protein Domains with Known Functions 

      Hovland, Henrikke Nilsen; Mchaina, Eunice Kabanyana; Vetti, Hildegunn Høberg; Ariansen, Sarah Louise; Sjursen, Wenche; Van Ghelue, Marijke; Haukanes, Bjørn Ivar; Knappskog, Per Morten; Aukrust, Ingvild; Berge, Elisabet Ognedal (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-19)
      : The BRCA1 protein is implicated in numerous important cellular processes to prevent genomic instability and tumorigenesis, and pathogenic germline variants predispose carriers to hereditary breast and ovarian cancer (HBOC). Most functional studies of missense variants in BRCA1 focus on variants located within the Really Interesting New Gene (RING), coiled-coil and BRCA1 C-terminal (BRCT) ...

    • Functional analysis of signaling pathways activated by Anisomycin and Dexamethasone in two different breast cancer cell lines 

      Brown, Rosaline (Mastergradsoppgave; Master thesis, 2022-05-12)
      While targeted therapy exists for ER-positive breast cancers, the treatment option for TNBC is conventional chemotherapy giving a poorer prognosis. It is therefore of interest to study molecular mechanisms and differences between MCF7 (ER-positive) and MDA-MB-231 (ER, PR, and HER2- negative). These cell lines are in vitro representative models for luminal A (non-aggressive) and basal-like (aggressive) ...

    • Functional characterization of alpha- mannosidosis associated sequence variants 

      Nguyen, Lam Van (Master thesis; Mastergradsoppgave, 2008-12-24)
      Alpha-mannosidosis is a rare autosomal recessive lysosomal-storage disorder resulting from deficiency of lysosomal alpha-mannosidase activity. The disease shows a wide range of clinical phenotypes caused by intracellular accumulation of mannose-containing oligosaccharides, which ultimately may lead to mental retardation, hearing loss, skeletal changes and immune deficiency. Lysosomal alpha-mannosidase ...

    • Functional Domains of the Early Proteins and Experimental and Epidemiological Studies Suggest a Role for the Novel Human Polyomaviruses in Cancer 

      Moens, Ugo; Prezioso, Carla; Pietropaolo, Valeria (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-18)
      As their name indicates, polyomaviruses (PyVs) can induce tumors. Mouse PyV, hamster PyV and raccoon PyV have been shown to cause tumors in their natural host. During the last 30 years, 15 PyVs have been isolated from humans. From these, Merkel cell PyV is classified as a Group 2A carcinogenic pathogen (probably carcinogenic to humans), whereas BKPyV and JCPyV are class 2B (possibly carcinogenic ...

    • Functional High-Intensity Circuit Training Improves Body Composition, Peak Oxygen Uptake, Strength, and Alters Certain Dimensions of Quality of Life in Overweight Women 

      Sperlich, Billy; Wallmann-Sperlich, Birgit; Zinner, Christoph; Von Stauffenberg, Valerie; Losert, Heidrun; Holmberg, Hans-Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-03)
      The effects of circuit-like functional high-intensity training (Circuit<sub>HIIT</sub>) alone or in combination with high-volume low-intensity exercise (Circuit<sub>combined</sub>) on selected cardio-respiratory and metabolic parameters, body composition, functional strength and the quality of life of overweight women were compared. In this single-center, two-armed randomized, controlled study, ...

    • Functional recovery after accidental deep hypothermic cardiac arrest: Comparison of different cardiopulmonary bypass rewarming strategies 

      Filseth, Ole Magnus; Kondratyev, Timofey; Sieck, Gary C.; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-05)
      Introduction: Using a porcine model of accidental immersion hypothermia and hypothermic cardiac arrest (HCA), the aim of the present study was to compare effects of different rewarming strategies on CPB on need for vascular fluid supply, level of cardiac restitution, and cerebral metabolism and pressures.<p> <p>Materials and Methods: Totally sixteen healthy, anesthetized castrated male pigs were ...

    • Functional recovery is considered the most important target: a survey of dedicated professionals 

      Aahlin, Eirik Kjus; von Meyenfeldt, Maarten; Dejong, Cornelis H.C.; Ljungqvist, Olle; Fearon, Kenneth C.; Lobo, Dileep N; Revhaug, Arthur; Wigmore, Stephen J; Lassen, Kristoffer (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Functional screening of a human saliva metagenomic DNA reveal novel resistance genes against sodium hypochlorite and chlorhexidine 

      Wigand, Johannes; Tansirichaiya, Supathep; Winje, Endre; Al-Haroni, Mohammed (Journal article; Tidsskriftartikkel; Peer reviewed; Mastergradsoppgave; Master thesis, 2021-12-09)
      Objective - Many sections of the health care system are facing a major challenge making infectious disease problematic to treat; antimicrobial resistance (AMR). Identification and surveillance of the resistome have been highlighted as one of the strategies to overcome the problem. This study aimed to screen for AMR genes in an oral microbiota, a complex microbial system continuously exposed to ...

    • Functional selectivity and antidepressant activity of serotonin 1A receptor ligands 

      Chilmonczyk, Zdzislaw; Bojarski, Andrzej Jacek; Pilc, Andrzej; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
      Serotonin (5-HT) is a monoamine neurotransmitter that plays an important role in physiological functions. 5-HT has been implicated in sleep, feeding, sexual behavior, temperature regulation, pain, and cognition as well as in pathological states including disorders connected to mood, anxiety, psychosis and pain. 5-HT1A receptors have for a long time been considered as an interesting target for the ...

    • Functional transcriptomics in 17 year-old blood samples? Yes, we can! -Long-term RNA in situ stability in blood samples collected in PAXgene Blood RNA Tubes (PreAnalytiX GmbH) collected in 2003 

      Olsen, Karina Standahl; Schönborn, Maike; Kalle, Günther (Conference object; Konferansebidrag, 2021)
      Analysis of blood RNA transcription profiles is hindered by ex vivogene expression changes, as well as degradation and loss of RNA over time during specimen transportation and storage. The PAXgeneBlood RNA System was developed by PreAnalytiXto overcome these problems. So far, quality control data has shown that the PAXgene Blood RNA System stabilizes and preserves RNA in blood specimens for up to ...

    • Functional ultrasound of the anal canal. The effect of pregnancy and childbirth 

      Olsen, Ingrid Petrikke (Doctoral thesis; Doktorgradsavhandling, 2011-06-22)
      This thesis is concerned with functional three-dimensional ultrasound of the anal canal. Comparing acquisitions assessed with endoanal- and transvaginal transducers, the transvaginal transducer turned out to be as good as the endovaginal transducer. In addition, the curvatures, position and dimensions of the undisturbed anatomical structures in the anal canal, including the anal mucosa, could be ...

    • Functions of Vocalization in Sociosexual Behaviors in Rats (Rattus norvegicus) in a Seminatural Environment 

      Chu, Xi; Snoeren, Eelke; Ågmo, Anders j (Journal article; Tidsskriftartikkel, 2017-01-09)
      Both male and female rats produce vocalizations in the presence of a potential sexual partner. In this study, we evaluated the role of vocalizations in sociosexual behaviors in an ecologically valid procedure. Three males and 4 females were housed in a seminatural environment. In each group, 1 or 2 males and females were devocalized, and the other subjects were sham operated. Sociosexual interactions ...

    • The fundamental violence of physiotherapy: Emmanuel Levinas’s critique of ontology and its implications for physiotherapy theory and practice 

      Maric, Filip; Nicholls, David A (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-12)
      The fundamental role of ontology, epistemology, and ethics is widely recognised across the healthcare professions. Yet what is less known in physiotherapy is how ontology and epistemology potentially undermine the ethical intentions of our theories and practices. In this article, we draw on the work of 20th-century philosopher Emmanuel Levinas to highlight this problem. Particularly Levinas’s ethical ...

    • Funksjonell konnektivitet i cerebrale hvilenettverk og eksekutiv funksjon hos jenter med anorexia nervosa. En pilotstudie 

      Åseng, Robert André; Horn Johansen, Ann-Mari; Entner, Pia Silvana (Master thesis; Mastergradsoppgave, 2015-04-30)
      Tidligere forskning har antydet at pasienter med anorexia nervosa (AN) har økt funksjonell konnektivitet i cerebrale hvilenettverk, og svekket eksekutiv funksjon, sammenlignet med friske. På bakgrunn av tidligere forskning, forventet vi at pasientgruppen i denne studien ville vise høyere grad av funksjonell intrakonnektivitet i cerebrale hvilenettverk, og svekket eksekutiv funksjon, sammenlignet med ...

    • Funksjonell og dysfunksjonell grubling : Teoretiske perspektiver 

      Eide, Rudi (Master thesis; Mastergradsoppgave, 2014-04-30)
      Grubling, eller vedvarende selvfokusert tenkning, er et sentralt karaktertrekk ved depresjon og andre emosjonelle forstyrrelser. Kliniske teorier beskriver grubling som et dysfunksjonelt fenomen med negative konsekvenser for psykisk helse. Samtidig foreligger det forskning som indikerer at enkelte former for grubling kan være fordelaktig ved å bidra til problemløsning og emosjonell bearbeiding. ...

    • Funksjonsundersøkelser. Årsaker til sprikende resultater mellom ulike undersøkere ved undersøkelse av samme pasient 

      Bekkeli, Kine Beate (Master thesis; Mastergradsoppgave, 2006)

    • Funksjonsvurdering av gamle innlagt i sykehus. Med hovedvekt på delirium. 

      Sørhøy, Margrethe Almås (Master thesis; Mastergradsoppgave, 2005-09-15)