Functional Domains of the Early Proteins and Experimental and Epidemiological Studies Suggest a Role for the Novel Human Polyomaviruses in Cancer
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https://hdl.handle.net/10037/26294Date
2022-02-18Type
Journal articleTidsskriftartikkel
Peer reviewed
Abstract
As their name indicates, polyomaviruses (PyVs) can induce tumors. Mouse PyV, hamster
PyV and raccoon PyV have been shown to cause tumors in their natural host. During
the last 30 years, 15 PyVs have been isolated from humans. From these, Merkel cell PyV
is classified as a Group 2A carcinogenic pathogen (probably carcinogenic to humans),
whereas BKPyV and JCPyV are class 2B (possibly carcinogenic to humans) by the
International Agency for Research on Cancer. Although the other PyVs recently detected
in humans (referred to here as novel HPyV; nHPyV) share many common features with
PyVs, including the viral oncoproteins large tumor antigen and small tumor antigen, as
their role in cancer is questioned. This review discusses whether the nHPyVs may play
a role in cancer based on predicted and experimentally proven functions of their early
proteins in oncogenic processes. The functional domains that mediate the oncogenic
properties of early proteins of known PyVs, that can cause cancer in their natural host or
animal models, have been well characterized and we examined whether these functional
domains are conserved in the early proteins of the nHPyVs and presented experimental
evidence that these conserved domains are functional. Furthermore, we reviewed the
literature describing the detection of nHPyV in human tumors.
Publisher
Frontiers MediaCitation
Moens u, Prezioso C, Pietropaolo V. Functional Domains of the Early Proteins and Experimental and Epidemiological Studies Suggest a Role for the Novel Human Polyomaviruses in Cancer. Frontiers in Microbiology. 2022;13Metadata
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