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    • High prevalence of overweight and obesity among 6-year-old children in Finnmark County, North Norway 

      Kokkvoll, Ane Sofie; Jeppesen, Elisabeth; Juliusson, Petur Benedikt; Flægstad, Trond; Njølstad, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)

    • High prevalence of vertebral fractures and low trabecular bone score in patients with fragility fractures: A cross-sectional sub-study of NoFRACT 

      Borgen, Tove Tveitan; Bjørnerem, Åshild; Solberg, Lene Bergendal; Andreasen, Camilla; Brunborg, Cathrine; Stenbro, May-Britt; Hübschle, Lars Michael; Froholdt, Anne; Figved, Wender; Apalset, Ellen M; Gjertsen, Jan-Erik; Basso, Trude; Lund, Ida; Hansen, Ann Kristin; Stutzer, Jens-Meinhard; Dahl, Cecilie; Omsland, Tone Kristin; Nordsletten, Lars; Frihagen, Frede Jon; Eriksen, Erik Fink (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-08)
      <p><i>Purpose - </i>Norway has among the highest incidence rates of fractures in the world. Vertebral fracture assessment (VFA) and trabecular bone score (TBS) provide information about fracture risk, but their importance have not been studied in Norwegian patients with fragility fractures. The objectives of this study were to examine the clinical characteristics of a cohort of women and men with ...

    • High progesterone receptor expression in prostate cancer is associated with clinical failure 

      Grindstad, Thea; Andersen, Sigve; Al-Saad, Samer; Dønnem, Tom; Kiselev, Yury; Melbø-Jørgensen, Christian; Skjefstad, Kaja; Busund, Lill-Tove; Bremnes, Roy M.; Richardsen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-27)
      Background Prostate cancer is a highly heterogeneous disease and one of the leading causes of mortality in developed countries. Specific prognostic and predictive markers for prostate cancer patients are still lacking. A causal relationship between androgens and the development of prostate cancer is generally considered biologically plausible, but androgens are not the sole effector in the ...

    • High rate of per oral mecillinam treatment failure in community-acquired urinary tract infections caused by ESBL-producing escherichia coli 

      Søraas, Arne Vasli Lund; Sundsfjord, Arnfinn; Jørgensen, Silje Bakken; Liestøl, Knut; Jenum, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • High referral rates to secondary care by general practitioners in Norway are associated with GPs' gender and specialist qualifications in family medicine, a study of 4350 consultations 

      Ringberg, Unni; Fleten, Nils; Deraas, Trygve Sigvart; Hasvold, Toralf; Førde, Olav Helge (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Referral rates of general practitioners (GPs) are an important determinant of secondary care utilization. The variation in these rates across GPs is considerable, and cannot be explained by patient morbidity alone. The main objective of this study was to assess the GPs’ referral rate to secondary care in Norway, any associations between the referral decision and patient, GP, health care characteristics ...

    • High sensitivity C-reactive protein : a useful tool in risk assessment of patients with abdominal obesity? 

      Arntzen, Wenche (Master thesis; Mastergradsoppgave, 2012-06-05)
      Background: Many obese will eventually develop diabetes and cardiovascular disease. The metabolic syndrome is a cluster of risk factor for these diseases, and low-grade inflammation has been linked to all three conditions. Thesis aims: To investigate if high-sensitivity C-reactive protein can be a useful tool in risk assessment for the development of the metabolic syndrome in abdominally obese ...

    • High spatially sensitive quantitative phase imaging assisted with deep neural network for classification of human spermatozoa under stressed condition 

      Butola, Ankit; Popova, Daria; Prasad, Dilip K.; Ahmad, Azeem; Habib, Anowarul; Tinguely, Jean-Claude; Basnet, Purusotam; Acharya, Ganesh; Paramasivam, Senthilkumaran; Mehta, Dalip Singh; Ahluwalia, Balpreet Singh (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-04)
      Sperm cell motility and morphology observed under the bright field microscopy are the only criteria for selecting a particular sperm cell during Intracytoplasmic Sperm Injection (ICSI) procedure of Assisted Reproductive Technology (ART). Several factors such as oxidative stress, cryopreservation, heat, smoking and alcohol consumption, are negatively associated with the quality of sperm cell and ...

    • High throughput lipolysis-permeation in vitro model employing the mucus-PVPA barriers to assess drug absorption from lipid-based delivery systems 

      Brurok, Sunniva (Mastergradsoppgave; Master thesis, 2020-05-14)
      In vitro lipolysis models are commonly used to assess the performance of lipid-based drug delivery systems (LbDDSs) in terms of their drug absorption potential; however, this in vitro approach has not always shown to correlate well with in vivo data. Several studies suggest that adding an absorption step to the in vitro lipolysis model would give a better estimation of absorption for drugs incorporated ...

    • High tumor cell expression of microRNA-21 in node positive non-small cell lung cancer predicts a favorable clinical outcome 

      Stenvold, Helge; Dønnem, Tom; Andersen, Sigve; Al-Saad, Samer; Valkov, Andrey Yurjevich; Pedersen, Mona Irene; Busund, Lill-Tove; Bremnes, Roy M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • High-affinity von Willebrand factor binding does not affect the anatomical or hepatocellular distribution of factor VIII in rats 

      Øie, Cristina Ionica; Roepstorff, Kirstine; Behrens, Carsten; Bøggild Kristensen, Jesper; Karpf, Ditte Maria; Bolt, Gert; Gudme, Charlotte N.; Kjalke, Marianne; Smedsrød, Bård; Appa, Rupa Shree (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-05)
      Background: Von Willebrand factor (VWF) stabilizes factor VIII in the circulation and prevents its premature clearance.<p><p> Objective: To study the effects of VWF on FVIII clearance in rats with endogenous VWF.<p><p> Methods: Anatomical and hepatocellular distribution studies were performed in rats following intravenous administration of glycoiodinated recombinant FVIII (rFVIII) and a ...

    • High-Definition Transcranial Direct Current Stimulation Improves Delayed Memory in Alzheimer’s Disease Patients: A Pilot Study Using Computational Modeling to Optimize Electrode Position 

      Rasmussen, Ingrid Daae; Boayue, Nya Mehnwolo; Mittner, Matthias; Bystad, Martin Kragnes; Grønli, Ole Kristian; Vangberg, Torgil Riise; Csifcsak, Gabor; Aslaksen, Per M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-14)
      Background: The optimal stimulation parameters when using transcranial direct current stimulation (tDCS) to improve memory performance in patients with Alzheimer’s disease (AD) are lacking. In healthy individuals, inter-individual differences in brain anatomy significantly influence current distribution during tDCS, an effect that might be aggravated by variations in cortical atrophy in AD ...

    • High-density lipoprotein subfractions: Much ado about nothing or clinically important? 

      Lappegård, Knut Tore; Kjellmo, Christian Abendstein; Hovland, Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-18)
      High-density lipoproteins (HDL) are a heterogenous group of plasma molecules with a large variety in composition. There is a wide specter in lipid content and the number of different proteins that has been associated with HDL is approaching 100. Given this heterogeneity and the fact that the total amount of HDL is inversely related to the risk of coronary heart disease (CHD), there has been ...

    • High-Intensity Exercise Improves Fatigue, Sleep, and Mood in Patients With Axial Spondyloarthritis: Secondary Analysis of a Randomized Controlled Trial 

      Sveaas, Silje Halvorsen; Dagfinrud, Hanne; Berg, Inger Jorid; Provan, Sella Aarrestad; Johansen, Melissa Woll; Pedersen, Elisabeth; Bilberg, Annelie (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-04)
      <i>Objective</i> - Although exercise is recommended in the treatment of axial spondyloarthritis (axSpa), the focus has been on flexibility, and the effect of high-intensity exercises is unknown. The purpose of this study was to investigate the effect of high-intensity exercises on fatigue, sleep, and mood in patients with axSpA.<br><br> <i>Methods</i> - In this secondary analysis of a randomized ...

    • High-level mobility in chronic traumatic brain injury. A case-control study 

      Moen, Kine Therese (Master thesis; Mastergradsoppgave, 2011-11-01)
      Formål: Sammenligne forekomst av problemer med avansert grovmotorikk hos personer med kronisk moderat og alvorlig traumatisk hodeskade (TBI) med matchede kontroller. Design: Case-control. Måling av endepunkt: High-level mobility assessment tool (HiMAT). Metode: Vi rekrutterte 69 personer med kronisk TBI i alderen 16 til 65 år fra en kohort bestående av moderate og alvorlige TBI-pasienter fra ...

    • High-performing trauma teams: frequency of behavioral markers of a shared mental model displayed by team leaders and quality of medical performance 

      Johnsen, Bjørn Helge; Westli, Heidi Kristina; Espevik, Roar; Wisborg, Torben; Brattebø, Guttorm (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-10)
      Background:<br>High quality team leadership is important for the outcome of medical emergencies. However, the behavioral marker of leadership are not well defined. The present study investigated frequency of behavioral markers of shared mental models (SMM) on quality of medical management.<br>Method:<br>Training video recordings of 27 trauma teams simulating emergencies were analyzed according to ...

    • High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts 

      Godtliebsen, Gustav; Larsen, Kenneth Bowitz; Bhujabal, Zambarlal Babanrao; Opstad, Ida Sundvor; Nager Grifo, Mireia; Punnakkal, Abhinanda Ranjit; Kalstad, Trine; Olsen, Randi; Lund, trine; Prasad, Dilip K.; Agarwal, Krishna; Myrmel, Truls; Birgisdottir, Åsa birna (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-05)
      Mitochondria are susceptible to damage resulting from their activity as energy providers. Damaged mitochondria can cause harm to the cell and thus mitochondria are subjected to elaborate quality-control mechanisms including elimination via lysosomal degradation in a process termed mitophagy. Basal mitophagy is a house-keeping mechanism fine-tuning the number of mitochondria according to the metabolic ...

    • High-Sensitivity C-Reactive Protein Is an Independent Risk Factor for Non-Vertebral Fractures in Women and Men: the Tromsø Study 

      Dahl, Kristoffer Jensen (Master thesis; Mastergradsoppgave, 2014-05-02)
      We tested the hypothesis that high-sensitivity C-reactive protein (CRP) is an independent risk factor for non-vertebral fractures, and that CRP is associated with BMD, in both genders. We included 1902 women and 1648 men aged 55 and 74 years, who had CRP measured at baseline in the Tromsø Study, Norway in 2001. All non-vertebral fractures were registered from X-ray archives during an average of ...

    • High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study 

      Hald, Erin Mathiesen; Brækkan, Sigrid Kufaas; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brox, Jan; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      High-sensitivity C-reactive protein is associated with risk of arterial cardiovascular disease but conflicting results have been reported on its role in venous thromboembolic disease. The objective of our study was to investigate the association between high-sensitivity C-reactive protein levels and risk of future venous thromboembolism in a prospective cohort recruited from a general population. ...

    • High-speed TIRF and 2D super-resolution structured illumination microscopy with a large field of view based on fiber optic components 

      Ortkrass, Henning; Schürstedt, Jasmin; Wiebusch, Gerd; Szafranska, Karolina Joanna; McCourt, Peter Anthony; Huser, Thomas Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-16)
      Super-resolved structured illumination microscopy (SR-SIM) is among the most flexible, fast, and least perturbing fluorescence microscopy techniques capable of surpassing the optical diffraction limit. Current custom-built instruments are easily able to deliver two-fold resolution enhancement at video-rate frame rates, but the cost of the instruments is still relatively high, and the physical size ...

    • A high-throughput multiplexing and selection strategy to complete bacterial genomes 

      Alonso, Sergio Arredondo; Pöntinen, Anna K.; Cleon, Francois Pierre Alexandre; Gladstone, Rebecca Ashley; Schürch, Anita C.; Johnsen, Pål Jarle; Samuelsen, Ørjan; Corander, Jukka (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-09)
      Background: Bacterial whole-genome sequencing based on short-read technologies often results in a draft assembly formed by contiguous sequences. The introduction of long-read sequencing technologies permits those contiguous sequences to be unambiguously bridged into complete genomes. However, the elevated costs associated with long-read sequencing frequently limit the number of bacterial isolates ...