Blar i forfatter Det helsevitenskapelige fakultet "Bønaa, Kaare Harald"

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    • Analyses of Increased Mortality in New and Known Diabetes in Patients with Coronary Disease Enrolled in the NORSTENT Randomized Study 

      Mølstad, Per; Nordrehaug, Jan Erik; Steigen, Terje; Wilsgaard, Tom; Wiseth, Rune; Bønaa, Kaare Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05)
      Background: NORSTENT trial randomized 9,013 patients to percutaneous coronary intervention with drug-eluting stents (DES) or bare-metal stents (BMS) with a 5-year follow-up. Among the patients, 5,512 had measured either fasting glucose level or percent glycated hemoglobin (HbA1c) at the index procedure. That cohort constitutes the present study population analyzing mortality and evaluating treatment ...

    • Cardiovascular health and the modifiable burden of incident myocardial infarction: The Tromsø Study 

      Wilsgaard, Tom; Loehr, LR; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Bønaa, Kaare Harald; Njølstad, Inger; Heiss, G (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-06)
      Background: The American Heart Association has proposed an impact goal for the year 2020 to improve cardiovascular health by 20%. The objectives of the study were to assess the association between the proposed cardiovascular health metric score and incident myocardial infarction (MI) and to estimate the generalized impact fraction (GIF). <p>Methods: The health metric score was derived from ideal ...

    • Data on gender contrasts in the risk of incident myocardial infarction by age. The Tromsø Study 1979–2012 

      Albrektsen, Grethe; Heuch, Ivar; Løchen, Maja-Lisa; Thelle, Dag Steinar; Wilsgaard, Tom; Njølstad, Inger; Bønaa, Kaare Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-08)
      The data presented in this article relate to the research article entitled “Risk of incident myocardial infarction by gender: Interactions with serum lipids, blood pressure and smoking. The Tromsø Study 1979–2012” (Albrektsen et al., 2017) [1]. Data quantify the gender differences in the risk of myocardial infarction (MI) in terms of incidence rate ratios (IRR), in subgroups defined by serum lipids, ...

    • Drug-Eluting versus Bare-Metal Stents in Saphenous Vein Grafts Compared to Native Coronary Vessels: The Norwegian Coronary Stent Trial Study 

      Mølstad, Per; Nordrehaug, Jan Erik; Steigen, Terje; Wilsgaard, Tom; Wiseth, Rune; Rotevatn, Svein; Mannsverk, Jan Torbjørn; Larsen, Tommy; Larsby, Kristina; Skarstad, Sigrun; Fosse, Eivind Øygard; Dahl-Eriksen, Øystein; Bønaa, Kaare Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01)
      Background: Drug-eluting stents (DES) reduce target lesion revascularization (TLR) with no effect on mortality or myocardial infarction (MI) compared to bare-metal stents (BMS) in native vessels. Randomized stent studies in saphenous vein grafts (SVG) are few and the reported effects are ambiguous. The Norwegian Coronary Stent Trial study is the first to randomize lesions to percutaneous coronary ...

    • The effect of drug-eluting stents on target lesion revascularization in native coronary arteries: Results from the NORSTENT randomized study 

      Mølstad, Per; Nordrehaug, Jan Erik; Steigen, Terje; Melvær, Giil Lasse; Wilsgaard, Tom; Wiseth, Rune; Bønaa, Kaare Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06)
      <i>Background</i>: The NORSTENT trial randomized 9,013 patients to percutaneous coronary intervention (PCI) with a drug-eluting stent (DES) or bare-metal stent (BMS) with 5-year follow-up. No difference was found in the composite primary outcome of death from any cause and nonfatal spontaneous myocardial infarction after a median of 5 years of follow-up. Secondary outcomes included repeat ...

    • Employment status three years after percutaneous coronary intervention and predictors for being employed: A nationwide prospective cohort study 

      Olsen, Siv Jorunn Storli; Schirmer, Henrik; Wilsgaard, Tom; Bønaa, Kaare Harald; Hanssen, Tove Aminda (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-01)
      <i>Background</i> - Vocational support is recommended for patients in cardiac rehabilitation (CR), as returning to work is important in patients social readjusting after an acute coronary event. Information is lacking on whether CR leads to higher long-term employment after percutaneous coronary intervention (PCI).<p> <p><i>Aims</i> - The aims of this study were to determine employment status ...

    • Incidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: Findings from the Norwegian Coronary Stent Trial (NORSTENT) 

      Samuelsen, Per-Jostein; Eggen, Anne Elise; Steigen, Terje; Wilsgaard, Tom; Kristensen, Andreas; Skogsholm, Anne; Holme, Elizabeth; van den Heuvel, Christian; Nordrehaug, Jan Erik; Bendz, Bjørn; Nilsen, Dennis W.T.; Bønaa, Kaare Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-04)
      Introduction - Bleeding is a concern after percutaneous coronary intervention (PCI) and subsequent dual antiplatelet therapy (DAPT). We herein report the incidence and risk factors for major bleeding in the Norwegian Coronary Stent Trial (NORSTENT). <p> <p>Materials and methods - NORSTENT was a randomized, double blind, pragmatic trial among patients with acute coronary syndrome or stable coronary ...

    • Individual Patient Data Meta-analysis of Drug-eluting Versus Bare-metal Stents for Percutaneous Coronary Intervention in Chronic Versus Acute Coronary Syndromes 

      Piccolo, Raffaele; Bønaa, Kaare Harald; Efthimiou, Orestis; Varenne, Olivier; Baldo, Andrea; Urban, Philip; Kaiser, Christoph; de Belder, Adam; Lemos, Pedro A.; Wilsgaard, Tom; Reifart, Jörg; Ribeiro, Expedito E.; Serruys, Patrick WJC; Byrne, Robert A.; de la Torre Hernandez, Jose M.; Esposito, Giovanni; Wijns, William; Jüni, Peter; Windecker, Stephan; Valgimigli, Marco (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-06)
      New-generation drug-eluting stents (DES) strongly reduce restenosis and repeat revascu- larization compared with bare-metal stents (BMS) for percutaneous coronary interven- tion. There is residual uncertainty as to whether other prognostically relevant outcomes are affected by DES versus BMS concerning initial presentation (chronic coronary syn- drome [CCS] vs acute coronary syndrome [ACS]). We ...

    • Inter-rater reliability of a national acute stroke register 

      Varmdal, Torunn; Ellekjær, Hanne; Fjærtoft, Hild; Indredavik, Bent; Lydersen, Stian; Bønaa, Kaare Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-19)
      <p>Background: Medical quality registers are useful sources of knowledge about diseases and the health services. However, there are challenges in obtaining valid and reliable data. This study aims to assess the reliability in a national medical quality register. <p>Methods: We randomly selected 111 patients having had a stroke in 2012. An experienced stroke nurse completed the Norwegian Stroke ...

    • Is the ongoing obesity epidemic partly explained by concurrent decline in cigarette smoking? Insights from a longitudinal population study. The Tromsø Study 1994–2016 

      Løvsletten, Ola; Njølstad, Inger; Wilsgaard, Tom; Hopstock, Laila Arnesdatter; Jacobsen, Bjarne K.; Bønaa, Kaare Harald; Eggen, Anne Elise; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-23)
      <p>The increase of obesity coincides with a substantial decrease in cigarette smoking. We assessed post-cessation weight change and its contribution to the obesity epidemic in a general population in Norway. A total of 14,453 participants (52.6% women), aged 25–54 years in 1994, who attended at least two of four surveys in the Tromsø Study between 1994 and 2016, were included in the analysis. Hereof ...

    • Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 

      Albrektsen, Grethe; Wilsgaard, Tom; Heuch, Ivar; Løchen, Maja-Lisa; Thelle, Dag Steinar; Njølstad, Inger; Grimsgaard, Sameline; Bønaa, Kaare Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-14)
      Background - The atherosclerotic effect of an adverse lipid profile is assumed to accumulate throughout life, leading to increased risk of myocardial infarction (MI). Still, little is known about age at onset and duration of unfavorable lipid levels before MI.<p> <p>Methods and Results - Longitudinal data on serum lipid levels for 26 130 individuals (50.5% women, aged 20–89 years) were obtained ...

    • Validating Acute Myocardial Infarction Diagnoses in National Health Registers for Use as Endpoint in Research: The Tromsø Study 

      Varmdal, Torunn; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger; Nyrnes, Audhild; Grimsgaard, Sameline; Bønaa, Kaare Harald; Mannsverk, Jan; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-03)
      <i>Purpose</i>: To assess whether acute myocardial infarction (MI) diagnoses in national health registers are sufficiently correct and complete to replace manual collection of endpoint data for a population-based, epidemiological study.<br><br> <i>Patients and Methods</i>: Using the Tromsø Study Cardiovascular Disease Register for 2013– 2014 as gold standard, we calculated correctness (defined ...