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Coffee and Cholesterol - Impact of Brewing Methods
(Master thesis; Mastergradsoppgave, 2021-05-29)Objective/methods: Coffee, especially boiled/plunger coffee, raises serum cholesterol (S-TC and S-LDL) because of its diterpenes, cafestol and kahweol. Epidemiological research comparing all the different brewing methods’ impact on serum cholesterol was still yet to be done. The aim of this study was to quantify the association between serum total cholesterol and serum low-density lipoprotein (S-TC ... -
From student to professional – mastering the necessary non-technical skills. Assessment tools and effects of multi-professional simulation training
(Doctoral thesis; Doktorgradsavhandling, 2024-06-14)Non-technical skills include important skills such as communication, decision making, situational awareness and teamwork. Together with medical knowledge, these constitute the basic competence that all doctors must possess. This thesis takes a closer look at Norwegian medical students' non-technical skills. This thesis consists of three articles. In the first article, the necessary non-technical ... -
Long non-coding RNAs in ulcerative colitis
(Doctoral thesis; Doktorgradsavhandling, 2024-06-12)Ulcerative colitis (UC) is a chronic inflammatory condition of the large intestine, influenced by various factors such as genetics, environment, gut contents, and the host's immune system. It has been reported that epigenetic factors, such as long non-coding RNAs (lncRNAs) and DNA methylation, play a role in UC development. The contribution of lncRNAs to UC pathogenesis is not fully understood. ... -
Challenges in Defining a Reference Set of Differentially Expressed lncRNAs in Ulcerative Colitis by Meta-Analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-05)The study aimed to identify common differentially expressed lncRNAs from manually curated ulcerative colitis (UC) gene expression omnibus (GEO) datasets. Nine UC transcriptomic datasets of clearly annotated human colonic biopsies were included in the study. The datasets were manually curated to select active UC samples and controls. R packages geneknitR, gprofiler, clusterProfiler were used for gene ... -
Periodontitis is associated with decreased experimental pressure pain tolerance: The Tromsø Study 2015–2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-01)Aim - To assess the relationship between periodontitis and experimental pain tolerance.<p> <p>Materials and Methods - Participants from the population-based seventh survey of the Tromsø Study with data on periodontitis were included (n = 3666, 40–84 years old, 51.6% women). Pain tolerance was assessed through (i) pressure pain tolerance (PPT) test with a computerized cuff pressure algometry on ... -
Encouraging participation in physical activity for individuals with intellectual disability: motivational factors, barriers, and mHealth applications
(Doctoral thesis; Doktorgradsavhandling, 2024-06-11)This thesis focuses on participation in physical activity among adults with intellectual disabilities. The aim is to explore motivation, the use of mobile health applications, and identify barriers to participation in physical activity. The thesis sought to understand why some individuals engage in physical activity while others do not, and how technology can help increase activity levels. In the ... -
Behandling av ikke-småcellet lungekreft med kombinasjonen av immunterapi og angiogenesehemmere - Et systematisk litteraturstudium
(Master thesis; Mastergradsoppgave, 2022-05-28)Innen ikke-småcellet lungekreft (NSCLC) forskes det på en potensiell synergistisk effekt av kombinasjonen av angiogenesehemmere og immunterapi (med eller uten kjemoterapi). Immunterapi ansees som en av de største nyvinningene innen kreftbehandling, imidlertid vil ikke alle pasientgrupper dra nytte av behandlingen. Man tenker at angiogenesehemmere kan fremme antitumoreffekter via oppregulering av ... -
Er det en sammenheng mellom HbA1c og fysisk aktivitet hos tenåringer? Tromsøundersøkelsen: Fit Futures.
(Master thesis; Mastergradsoppgave, 2019-05-28)Bakgrunn: Grad av fysisk aktivitet går ned med økende alder. I tillegg ser man økende forekomst av livsstilsrelaterte sykdommer som diabetes type 2, der fysisk inaktivitet er en risiko for utvikling. Måling av langtidsblodsukker, HbA1c, har en viktig plass i diagnostikk og behandling av diabetes. Studier av sammenhengen mellom langtidsblodsukker og fysisk aktivitet hos tenåringer er få og viser ... -
Multisite pain in adolescents and the association with ACE
(Master thesis; Mastergradsoppgave, 2022-05-28)Background: Both children and adolescents often express musculoskeletal pain without a clear somatic cause. The prevalence of musculoskeletal pain has been shown to be increasing. Additionally, there has been described a sharp rise in prevalence of so-called adverse childhood experiences (ACE), and studies have shown that musculoskeletal pain may be related to different ACE. The aim of this study ... -
Human Gut Colonisation by the Klebsiella pneumoniae Species Complex: Detection, Duration, Dynamics, and Microbiota Associations
(Doctoral thesis; Doktorgradsavhandling, 2024-06-10)The Klebsiella pneumoniae Species Complex (KpSC) is an important group of human pathogens, of which, Klebsiella pneumoniae is most clinically important and frequently associated with antimicrobial resistance (AMR). K. pneumoniae gastrointestinal tract (GIT) colonisation is a key infection risk factor and hub for AMR dissemination. Here we investigated and compared the ZKIR-qPCR and whole metagenomic ... -
Sammenligning av pasienter med type 1 og type 2 hjerteinfarkt innlagt ved Nordlandssykehuset Bodø i 2019
(Master thesis; Mastergradsoppgave, 2022-05-24)Innledning Akutt myokardielt infarkt (AMI) er en tilstand hvor det oppstår en blokkering av blodtilstrømningen til en del av hjertemuskulaturen. Iskemisk hjertesykdom er den vanligste dødsårsaken globalt. Type 1 AMI skyldes sykdom i en koronararterie (plakkruptur og trombose), mens type 2 AMI skyldes økt oksygenbehov eller redusert -tilførsel. Invasiv behandling av type 1 AMI er perkutan koronar ... -
Respiratory morbidity and therapy in very preterm infants – a population-based study from 2009-2018
(Master thesis; Mastergradsoppgave, 2022-05-24)<p>Introduction: The association between respiratory support and lung disease is known. This study analysed the duration of different respiratory managements for preterm infants born before week 28 and between week 28-31 and preterm infants with BPD. Regional differences were also evaluated. <p>Materials and methods: a nationwide population-based registry study, and the data is gathered from ... -
Hvilken rolle spiller en observasjonspost på et sykehus? En studie av innleggelser på observasjonsposten ved Nordlandssykehuset Bodø 2016-2021
(Master thesis; Mastergradsoppgave, 2022-05-27)Sammendrag Tittel: Hvilken rolle spiller en observasjonspost på et sykehus? En studie av innleggelser på observasjonsposten ved Nordlandssykehuset Bodø 2016-2021 Formål: Denne oppgaven har som formål å kartlegge pasientpopulasjonen som har blitt behandlet på observasjonsposten gjennom virksomhetsregistrering gjort i DIPS Arena. Oppgaven har også som formål å kartlegge DRG-produksjonen til ... -
Sekundærprofylakse etter perkutan koronar intervensjon ved Nordlandssykehuset
(Master thesis; Mastergradsoppgave, 2022-05-26)Bakgrunn: Hjerte- og karsykdom er en ledende årsak til morbiditet og mortalitet på verdensbasis. Selv om det har vært en signifikant bedring i behandlingen de siste tiårene, har behandling på lengre sikt vist seg å være utfordrende. Morbiditeten etter akutt koronarsyndrom har vist seg å være høy, hvor en stor andel opplever nye kardiovaskulære hendelser i løpet av de to første årene. I dag foreligger ... -
Moving sperm forward
(Mastergradsoppgave; Master thesis, 2023-05-26)Objective: The purpose of this study was to investigate a manual sperm sorting method (Swim-up) and a non-invasive microfluidics method (Zymot microfluidics) with emphasis on formation of reactive oxygen species (ROS) and DNA fragmentation as objective measurements of spermatozoa quality. Standard phase contrast imaging of spermatozoa was compared with quantitative phase contrast microscopy (QPM) ... -
CT-veiledet lungebiopsi ved radiologisk avdeling UNN: Komplikasjonsfrekvens og risikofaktorer for komplikasjoner. En retrospektiv kvalitetsstudie.
(Master thesis; Mastergradsoppgave, 2022-05-25)Objektiv: Dette er en retrospektiv kvalitetsstudie med formål å undersøke komplikasjonsfrekvens og risikofaktorer for komplikasjoner ved CT-veiledet lungebiopsi utført ved UNN Tromsø. Vi har også undersøkt diagnostisk treffsikkerhet ved prosedyren. Materiale og metode: Alle pasienter som hadde fått utført CT-veiledet lungebiopsi ved radiologisk avdeling, UNN Tromsø i løpet av perioden 17/11/2020 ... -
Characterization of extracellular vesicles from U-2OS15E, a human osteosarcoma cell line persistently infected by BK polyomavirus
(Mastergradsoppgave; Master thesis, 2021-05-25)The human polyomavirus BKPyV infects most people worldwide and establishes a lifelong persistent infection in the renourinary tract. The virus rarely gives symptoms in healthy people, but it can cause severe disease under certain immunocompromised states. Despite its high prevalence, our knowledge about how the virus evades host immunity and persists still poor. Extracellular vesicles (EVs) ... -
How does the number of previous operations affect patient-rated outcome after surgery for lumbar spinal stenosis or lumbar disc herniation? A population-based cohort study from the Norwegian Registry for Spine Surgery
(Master thesis; Mastergradsoppgave, 2021-05-25)Background: Several small, mainly single centre studies have linked repeated operations to inferior outcomes compared to primary operations after lumbar spine surgery. Few studies have specifically quantified the influence of previous operations on the outcome. Objectives: The aim of the study was to examine whether, and if so, to which extent the number of previous operations is associated with ... -
How Religion and Spirituality Impact Mental Health and Mental Help-Seeking Behavior in Arctic Norway: an Epidemiological Study Adopting the SAMINOR 2 Questionnaire Survey
(Doctoral thesis; Doktorgradsavhandling, 2024-06-07)<p><i>Objectives:</i> Most international studies have shown that religion and spirituality (R/S) are related to better mental health, yet the Indigenous Sámi—being more committed to R/S than the majority population in the area—have poorer mental health and are more inclined toward suicidal behavior. Laestadianism—an important R/S factor for these people and this region—is related to poorer mental ... -
Real-time feedback on chest compression efficacy by hands-free carotid Doppler in a porcine model
(Journal article; Tidsskriftartikkel, 2024-02-20)Aim: Current guidelines for cardiopulmonary resuscitation (CPR) recommend a one-size-fits-all approach in relation to the positioning of chest compressions. We recently developed RescueDoppler, a hands-free Doppler ultrasound device for continuous monitoring of carotid blood flow velocity during CPR. The aim of the present study is to investigate whether RescueDoppler via real-time hemodynamic ...
