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dc.contributor.advisorVasskog, Terje
dc.contributor.advisorHansen, Espen
dc.contributor.advisorAndersen, Jeanette Hammer
dc.contributor.advisorJensen, Einar
dc.contributor.authorAmmari, Yashar
dc.description.abstractMetridium senile, Halocynthia pyriformis and ParaParastichopus tremulus were subjected to organic and aqueous extraction. The aqueous extract was made with water, while the organic was made with dichloromethane and methanol in 1:1 ratio. The aqueous and organic extracts were fractionated on reversed-phase HPLC and tested for antiviral activity against Herpes simplex virus-1. All the three organisms displayed anti-viral activity in the primary screening, but when retested their activity were lost. During the work with the thesis Dendrodoa aggregata was included.Screening of D.aggregata had shown that deoxytubastrine had antiviral activity in pilot studies. Tubasterine has shown antiviral activity in earlier studies so it was decided to purify and test deoxytubastrine against HSV-1. Analysis on LC-MS ESI-TOF in positive mode indicated the active compound with m/z 178.0906 amu which gave us the elemental composition C9H11N30. The identity of deoxytubastrine was confirmed by LC-MS ESI-TOF in positive mode and 1H-NMR. However, pure deoxytubastrine did not show any pronounced anti-viral activity.en
dc.publisherUniversitetet i Tromsøen
dc.publisherUniversity of Tromsøen
dc.rights.holderCopyright 2010 The Author(s)
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)en_US
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440::Analytical chemistry: 445en
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440::Analytisk kjemi: 445en
dc.titleIsolation and characterization of antiviral compounds from marine organismsen
dc.typeMaster thesisen

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Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)