English
norskPostpneumonectomy pulmonary edema and the nitric oxide pathway : experimental studies in sheep
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https://hdl.handle.net/10037/4634
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Thesis introduction (PDF)
E.V. Suborov, A.A. Smetkin, T.V. Kondratiev, A.Y. Valkov, V.V. Kuzkov, M.Y. Kirov and L.J. Bjertnaes: 'Inhibitor of neuronal nitric oxide synthase improves gas exchange in ovine ventilator-induced lung injury after pneumonectomy', BMC Anesthesiology (2012), 12:10. (PDF)
Date
2012-11-07Type
Doctoral thesisDoktorgradsavhandling
Abstract
Ventilator-induced lung injury after pneumonectomy, a life-threatening complication of excessive one-lung mechanical ventilation
Lung edema after lung resection is associated with a mortality of 50–100% and no cure. In sheep we found that removal of one lung followed by excessive one-lung ventilation triggered a severe lung injury with lung edema. This is a novel model of acute lung injury (ALI) in a large animal. Inhibition of neuronal nitric oxide synthase improved oxygenation, but did not prevent lung edema from developing.
Description
Papers 1 & 2 of the thesis are not available in Munin:
1. V.V. Kuzkov, E.V. Suborov, M.Y. Kirov, V.N. Kuklin, M. Sobhkhez, S. Johnsen, K. Waerhaug and L.J. Bjertnaes: 'Extravascular lung water after pneumonectomy and one-lung ventilation in sheep', Critical Care Medicine (2007), vol. 35, no. 6:1550-1559. Available at http://dx.doi.org/10.1097/01.CCM.0000265739.51887.2B
2. E.V. Suborov, V.V. Kuzkov, M. Sobhkhez, M.Y. Kirov and L.J. Bjertnaes: 'The effects of methylene blue on ovine post-pneumonectomy pulmonary oedema', Acta Anaesthesiologica Scandinavica (2010), vol. 54, no. 9:1089–109. Available at http://dx.doi.org/10.1111/j.1399-6576.2010.02287.x
1. V.V. Kuzkov, E.V. Suborov, M.Y. Kirov, V.N. Kuklin, M. Sobhkhez, S. Johnsen, K. Waerhaug and L.J. Bjertnaes: 'Extravascular lung water after pneumonectomy and one-lung ventilation in sheep', Critical Care Medicine (2007), vol. 35, no. 6:1550-1559. Available at http://dx.doi.org/10.1097/01.CCM.0000265739.51887.2B
2. E.V. Suborov, V.V. Kuzkov, M. Sobhkhez, M.Y. Kirov and L.J. Bjertnaes: 'The effects of methylene blue on ovine post-pneumonectomy pulmonary oedema', Acta Anaesthesiologica Scandinavica (2010), vol. 54, no. 9:1089–109. Available at http://dx.doi.org/10.1111/j.1399-6576.2010.02287.x
Publisher
University of TromsøUniversitetet i Tromsø
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