• Involvement of A13 dopaminergic neurons in prehensile movements but not reward in the rat 

      Garau, Celia; Hayes, Jessica; Chiacchierini, Giulia; Mccutcheon, James Edgar; Apergis-Schoute, John (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-09)
      Tyrosine hydroxylase (TH)-containing neurons of the dopamine (DA) cell group A13 are well positioned to impact known DA-related functions as their descending projections innervate target regions that regulate vigilance, sensory integration, and motor execution. Despite this connectivity, little is known regarding the functionality of A13-DA circuits. Using TH-specific loss-of-function methodology ...
    • Restriction of dietary protein in rats increases progressive-ratio motivation for protein 

      Chiacchierini, Giulia; Naneix, Fabien; Apergis-Schoute, John; McCutcheon, James Edgar (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-29)
      Low-protein diets can impact food intake and appetite, but it is not known if motivation for food is changed. In the present study, we used an operant behavioral task – the progressive ratio test – to assess whether motivation for different foods was affected when rats were maintained on a protein-restricted diet (REST, 5% protein diet) compared to non-restricted control rats (CON, 18% protein). ...