Blar i forfatter Institutt for psykologi "Heijkoop, Roy"

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    • Assessment of sexual behavior in rats: the potentials and pitfalls 

      Heijkoop, Roy; Huijgens, Patty Thalia; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-27)
      In the field of behavioral neuroscience, it is essential to use the appropriate animal models for the topic of investigation. Using the wrong model can result in false interpretation of the results. In this review we will discuss the animal models used to study sexual behavior, with a focus on rats. We will discuss the potentials and pitfalls of the different paradigms and try to make recommendations ...

    • CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state 

      Huijgens, Patty Thalia; Heijkoop, Roy; Vanderschuren, Louk; Lesscher, Heidi; Snoeren, Eelke Mirthe Simone (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-24)
      This study aims to investigate the underlying neurobiological mechanisms that regulate natural reward seeking behaviors, specifically in the context of sexual behavior and sucrose self-administration. The role of CaMKIIa+neurons in the bed nucleus of the stria terminalis (BNST) was explored using chemogenetic silencing and -stimulation. Additionally, the study examined how these effects ...

    • Changes in reward-induced neural activity upon Cafeteria Diet consumption 

      Heijkoop, Roy; Ferrer Lalanza, Jaume; Solanas, Montserrat; Álvarez-Monell, Adam; Subias-Gusils, Alex; Escorihuela, Rosa; Snoeren, Eelke Mirthe Simone (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-01)
      Excessive consumption of highly palatable foods rich in sugar and fat, often referred to as “junk” or “fast” foods, plays a central role in the development of obesity. The highly palatable characteristics of these foods activate hedonic and motivational mechanisms to promote food-seeking behavior and overeating, which is largely regulated by the brain reward system. Excessive junk food consumption ...

    • Effects of perinatal fluoxetine exposure on novelty-induced social and non-social investigation behaviors in a seminatural environment 

      Sylte, Ole Christian; Johansen, Jesper Solheim; Heinla, Indrek; Houwing, Danielle; Olivier, Jocelien D.A.; Heijkoop, Roy; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-23)
      Selective serotonin reuptake inhibitors (SSRIs) are increasingly prescribed as medication for various afective disorders during pregnancy. SSRIs cross the placenta and afect serotonergic neurotransmission in the fetus, but the neurobehavioral consequences for the ofspring remain largely unclear. Recent rodent research has linked perinatal SSRI exposure to alterations in both social and non-social ...

    • Female rat sexual behavior is unaffected by perinatal fluoxetine exposure 

      Hegstad, Jan; Huijgens, Patty Thalia; Houwing, Danielle; Olivier, Jocelien; Heijkoop, Roy; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-22)
      Serotonin plays an important role in adult female sexual behavior, however little is known about the influence of serotonin during early development on sexual functioning in adulthood. During early development, serotonin acts as neurotrophic factor, while it functions as a modulatory neurotransmitter in adulthood. The occurrence of serotonin release, could thus have different effects on behavioral ...

    • Perinatal fluoxetine exposure changes social and stress-coping behavior in adult rats housed in a seminatural environment 

      Houwing, Danielle; Heijkoop, Roy; Olivier, Jocelien; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-06)
      The use of selective serotonin reuptake inhibitors (SSRI) during pregnancy has increased tremendously, but the consequences for the offspring remain largely unclear. Several studies have described potential effects of perinatal SSRI-exposure on neurobehavioral outcomes using simplified rodent test set-ups, however these set-ups only assess a small fraction of the behavior. For translational purposes ...

    • Sexual Incentive Motivation 

      Huijgens, Patty; Heijkoop, Roy; Snoeren, Eelke (Chapter; Bokkapittel, 2023-05-17)
      Motivation can be described as the processes that activate, direct, and determine the persistence of goal-directed behavior. A certain level of sexual motivation is required to activate approach behavior which could potentially lead to copulation and reproduction. Here, we discuss the use of the sexual incentive motivation test to assess the magnitude of sexual motivation in rodents in response to ...

    • Silencing and stimulating the medial amygdala impairs ejaculation but not sexual incentive motivation in male rats 

      Huijgens, Patty Thalia; Heijkoop, Roy; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-24)
      The medial amygdala (MeA) is a sexually dimorphic brain region that integrates sensory information and hormonal signaling, and is involved in the regulation of social behaviors. Lesion studies have shown a role for the MeA in copulation, most prominently in the promotion of ejaculation. The role of the MeA in sexual motivation, but also in temporal patterning of copulation, has not been extensively ...

    • Third-party prosocial behavior in adult female rats is impaired after perinatal fluoxetine exposure 

      Heinla, Indrek; Heijkoop, Roy; Houwing, Danielle; Olivier, Jocelien; Snoeren, Eelke (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-26)
      SSRIs are commonly used to treat pregnant women with depression. However, SSRIs can cross the placenta and affect the development of the fetus. The effects of perinatal SSRI exposure, and especially the effects on social behavior, are still incompletely documented. This study first aims to investigate whether rats show prosocial behavior in the form of consolation behavior. Secondly, it aims to ...