English
norskStaphylococcus aureus colonisation and host-microbe interactions
Permanent link
https://hdl.handle.net/10037/4738
Date
2013-01-18Type
Doctoral thesisDoktorgradsavhandling
Abstract
Why are some people carriers of Staphylococcus aureus while others are not? Is the pathogenesis of S. aureus just a mishap, or is it a well-regulated performance showing us the versatility of this commensal bacterium? Even after all these years of research, we don’t know for sure, and new insights are needed to completely answer these and other questions regarding S. aureus colonisation and infection. As treatment of S. aureus infections can be challenging and may even result in treatment failure, it is of the utmost importance to prevent infections from arising. By gaining insight on S. aureus nasal colonisation and the close interactions between the microbe and the host, we hope that eventually, a better understanding may provide us with novel means for targeted intervention and treatment. Vi undersøkte neseprøver fra 4000 voksne deltakere i den sjette Tromsøundersøkelsen. Alle gule stafylokokker (S. aureus) fra denne studien ble typebestemt ved hjelp av spa-typing som avdekket 400 ulike spa-typer. Vi fant sammenhenger mellom enkelte spa-typer og kjønn og/eller alder hos nesebærerne. Noen spa-typer var vanligere blant helsearbeidere enn hos andre. Disse resultatene tyder på at egenskaper både hos bakterien og hos verten spiller inn i bærerskap av S. aureus. Bakterien er avhengig av to viktige egenskaper for å overleve i nesa; den må feste seg til huden og kunne unnslippe immunforsvaret. I denne sammenheng undersøkte vi to stafylokokk-proteiner, SpA og TirS. SpA er vanligvis festet til bakteriens cellevegg, men blant ca. 14000 prøver fant vi 7 tilfeller hvor SpA ikke bandt til celleveggen. Fem av disse prøvene kom fra blodkultur og en fra en MRSA-infeksjon, noe som tyder på at S. aureus kan forårsake sykdom uten SpA festet til celleveggen. TirS ble vist både å kunne manipulere immunforsvaret samt bidra til invasjon av humane celler.
Description
The papers of this thesis are not available in Munin:
1. Maria Sangvik, Renate Slind Olsen, Karina Olsen, Gunnar Skov Simonsen, Anne- Sofie Furberg, and Johanna U. Ericson Sollid: 'Age- and gender-associated Staphylococcus aureus spa types found among nasal carriers in a general population : the Tromsø Staph and Skin Study', Journal of Clinical Microbiology (2011), vol. 49, no. 12:4213-4218. Available at http://dx.doi.org/10.1128/JCM.05290-11 The accepted manuscript version of this paper is available in Munin at http://hdl.handle.net/10037/4077
2. Karina Olsen, Maria Sangvik, Gunnar Skov Simonsen, Johanna U. Ericson Sollid, Arnfinn Sundsfjord, Inger Thune and Anne-Sofie Furberg: 'Prevalence and population structure of Staphylococcus aureus nasal carriage in healthcare workers in a general population. The Tromsø Staph and Skin Study', Epidemiology and Infection (2013), vol.141, no.1:143-152. Available at http://dx.doi.org/10.1017/S0950268812000465
3. Marit Sørum, Maria Sangvik, Marc Stegger, Renate S. Olsen, Mona Johannessen, Robert Skov, and Johanna U. Ericson Sollid: 'Staphylococcus aureus mutants lacking cell-wall bound protein A found in isolates from bacteraemia, MRSA-infection and a healthy nasal carrier' (manuscript).
4. Fatemeh Askarian, Maria Sangvik, Anne-Sofie Furberg, Anne-Merethe Hanssen, Johanna U. Ericson Sollid and Mona Johannessen: 'Staphylococcus aureus TIR-domain protein, TirS, negatively interferes with TLR2-, MyD88- and TIRAP-mediated NF-κB signaling and increases intracellular bacterial accumulation' (manuscript)
1. Maria Sangvik, Renate Slind Olsen, Karina Olsen, Gunnar Skov Simonsen, Anne- Sofie Furberg, and Johanna U. Ericson Sollid: 'Age- and gender-associated Staphylococcus aureus spa types found among nasal carriers in a general population : the Tromsø Staph and Skin Study', Journal of Clinical Microbiology (2011), vol. 49, no. 12:4213-4218. Available at http://dx.doi.org/10.1128/JCM.05290-11 The accepted manuscript version of this paper is available in Munin at http://hdl.handle.net/10037/4077
2. Karina Olsen, Maria Sangvik, Gunnar Skov Simonsen, Johanna U. Ericson Sollid, Arnfinn Sundsfjord, Inger Thune and Anne-Sofie Furberg: 'Prevalence and population structure of Staphylococcus aureus nasal carriage in healthcare workers in a general population. The Tromsø Staph and Skin Study', Epidemiology and Infection (2013), vol.141, no.1:143-152. Available at http://dx.doi.org/10.1017/S0950268812000465
3. Marit Sørum, Maria Sangvik, Marc Stegger, Renate S. Olsen, Mona Johannessen, Robert Skov, and Johanna U. Ericson Sollid: 'Staphylococcus aureus mutants lacking cell-wall bound protein A found in isolates from bacteraemia, MRSA-infection and a healthy nasal carrier' (manuscript).
4. Fatemeh Askarian, Maria Sangvik, Anne-Sofie Furberg, Anne-Merethe Hanssen, Johanna U. Ericson Sollid and Mona Johannessen: 'Staphylococcus aureus TIR-domain protein, TirS, negatively interferes with TLR2-, MyD88- and TIRAP-mediated NF-κB signaling and increases intracellular bacterial accumulation' (manuscript)
Publisher
University of TromsøUniversitetet i Tromsø
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