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dc.contributor.authorWaterloo, Svanhild Haugnes
dc.contributor.authorNgyen, T
dc.contributor.authorAhmed, Luai A.
dc.contributor.authorCenter, J
dc.contributor.authorMorseth, Bente
dc.contributor.authorNgyen, ND
dc.contributor.authorEisman, John A.
dc.contributor.authorSøgaard, Anne Johanne
dc.contributor.authorEmaus, Nina
dc.date.accessioned2013-03-06T12:59:26Z
dc.date.available2013-03-06T12:59:26Z
dc.date.issued2012
dc.description.abstractVertebral fractures, the most common type of osteoporotic fractures, are associated with increased risk of subsequent fracture, morbidity, and mortality. The aim of this study was to examine the contribution of important risk factors to the variability in vertebral fracture risk. Vertebral fracture was ascertained by VFA method (DXA, GE Lunar Prodigy) in 2887 men and women, aged between 38 and 87 years, in the population-based Tromsø Study 2007/2008. Bone mineral density (BMD; g/cm2) at the hip was measured by DXA. Lifestyle information was collected by questionnaires. Multivariable logistic regression model, with anthropometric and lifestyle factors included, was used to assess the association between each or combined risk factors and vertebral fracture risk. Population attributable risk was estimated for combined risk factors in the final multivariable model. In both sexes, age (odds ratio [OR] per 5 year increase: 1.32; 95% CI 1.19-1.45 in women and 1.21; 95% CI 1.10-1.33 in men) and BMD (OR per SD decrease: 1.60; 95% CI 1.34-1.90 in women and1.40; 95% CI 1.18-1.67 in men) were independent risk factors for vertebral fracture. At BMD levels higher than 0.85 g/cm2, men had a greater risk of fracture than women (OR 1.52; 95% CI 1.14-2.04), after adjusting for age. In women and men, respectively, approximately 46% and 33% of vertebral fracture risk was attributable to advancing age (more than 70 years) and low BMD (less than 0.85 g/cm2), with the latter having a greater effect than the former. These data confirm that age and BMD are major risk factors for vertebral fracture risk. However, in both sexes the two factors accounted for less than half of fracture risk. The identification of individuals with vertebral fracture is still a challenge.en
dc.descriptionThis article is part of Svanhild H. Waterloo's doctoral thesis, available in Munin at <a href=http://hdl.handle.net/10037/5557>http://hdl.handle.net/10037/5557</a>
dc.identifier.citationBMC Musculoskeletal Disorders (2012), 13:163en
dc.identifier.cristinIDFRIDAID 948733
dc.identifier.doihttp://dx.doi.org/10.1186/1471-2474-13-163
dc.identifier.issn1471-2474
dc.identifier.urihttps://hdl.handle.net/10037/4876
dc.identifier.urnURN:NBN:no-uit_munin_4595
dc.language.isoengen
dc.publisherBioMed Centralen
dc.rights.accessRightsopenAccess
dc.subjectRyggvirvelen
dc.subjectBrudden
dc.subjectOsteoporoseen
dc.subjectRisikofaktoreren
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Anatomy, physical anthropology: 717en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Anatomi, fysisk antropologi: 717en
dc.titleImportant risk factors and attributable risk of vertebral fractures in the population-based Tromsø studyen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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