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dc.contributor.authorSmeland, Eivind
dc.contributor.authorKilvær, Thomas Karsten
dc.contributor.authorSørbye, Sveinung Wergeland
dc.contributor.authorValkov, Andrey Yurjevich
dc.contributor.authorAndersen, Sigve
dc.contributor.authorBremnes, Roy M.
dc.contributor.authorBusund, Lill-Tove
dc.contributor.authorDønnem, Tom
dc.date.accessioned2013-03-07T09:20:19Z
dc.date.available2013-03-07T09:20:19Z
dc.date.issued2012
dc.description.abstractWe aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIFregulated glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STS). Methods. Duplicate cores with viable tumor tissue from206 patients with non-GIST STS were obtained and tissue microarrays were constructed. Immunohistochemistry (IHC) was used to evaluate expression of hypoxic markers. Results. In univariate analyses, GLUT-1 (P < 0.001) and HIF-2α (P = 0.032) expression correlated significantly with a poor disease-specific survival (DSS). In the multivariate analysis, however, only high expression of GLUT-1 (HR 1.7, CI 95% 1.1–2.7, P = 0.021) was a significant independent prognostic indicator of poor DSS. Conclusion. GLUT-1 is a significant independent negative prognostic factor in non-GIST STS.en
dc.identifier.citationSarcoma (2012), article ID 541650, 10 pp.en
dc.identifier.issn1357-714X
dc.identifier.otherFRIDAID 968420
dc.identifier.otherhttp://dx.doi.org/10.1155/2012/541650
dc.identifier.urihttp://hdl.handle.net/10037/4888
dc.identifier.urnURN:NBN:no-uit_munin_4615
dc.language.isoengen
dc.publisherTaylor and Francis Ltd.en
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en
dc.titlePrognostic Impacts of Hypoxic Markers in Soft Tissue Sarcomaen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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