Show simple item record

dc.contributor.authorSmeland, Eivind
dc.contributor.authorKilvær, Thomas Karsten
dc.contributor.authorSørbye, Sveinung Wergeland
dc.contributor.authorValkov, Andrey Yurjevich
dc.contributor.authorAndersen, Sigve
dc.contributor.authorBremnes, Roy M.
dc.contributor.authorBusund, Lill-Tove
dc.contributor.authorDønnem, Tom
dc.date.accessioned2013-03-07T09:20:19Z
dc.date.available2013-03-07T09:20:19Z
dc.date.issued2012
dc.description.abstractWe aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIFregulated glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STS). Methods. Duplicate cores with viable tumor tissue from206 patients with non-GIST STS were obtained and tissue microarrays were constructed. Immunohistochemistry (IHC) was used to evaluate expression of hypoxic markers. Results. In univariate analyses, GLUT-1 (P < 0.001) and HIF-2α (P = 0.032) expression correlated significantly with a poor disease-specific survival (DSS). In the multivariate analysis, however, only high expression of GLUT-1 (HR 1.7, CI 95% 1.1–2.7, P = 0.021) was a significant independent prognostic indicator of poor DSS. Conclusion. GLUT-1 is a significant independent negative prognostic factor in non-GIST STS.en
dc.identifier.citationSarcoma (2012), article ID 541650, 10 pp.en
dc.identifier.issn1357-714X
dc.identifier.otherFRIDAID 968420
dc.identifier.otherhttp://dx.doi.org/10.1155/2012/541650
dc.identifier.urihttps://hdl.handle.net/10037/4888
dc.identifier.urnURN:NBN:no-uit_munin_4615
dc.language.isoengen
dc.publisherTaylor and Francis Ltd.en
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en
dc.titlePrognostic Impacts of Hypoxic Markers in Soft Tissue Sarcomaen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


File(s) in this item

Thumbnail
Thumbnail

This item appears in the following collection(s)

Show simple item record