Now showing items 1-20 of 308

    • T cell and monocyte/macrophage activation markers associate with adverse outcome, but give limited prognostic value in anemic patients with heart failure: results from RED-HF 

      Abraityte, Aurelija; Aukrust, Pål; Kou, Lei; Anand, Inder S.; Young, James; Mcmurray, John J.V.; van Veldhuisen, Dirk J.; Gullestad, Lars; Ueland, Thor (Journal article; Tidsskriftartikkel; Preprint; Manuskript, 2018-07-26)
      <i>Background</i>: Activated leukocytes may contribute to the development and progression of heart failure (HF). We investigated the predictive value of circulating levels of stable and readily detectable markers reflecting both monocyte/macrophage and T-cell activity, on clinical outcomes in HF patients with reduced ejection fraction (HFrEF).<p> <p><i>Methods</i>: The association between ...
    • Genomic characterization of multidrug-resistant ESBL-producing Klebsiella pneumoniae isolated from a Ghanaian teaching hospital 

      Agyepong, Nicholas; Govinden, Usha; Owusu-Ofori, Alex; Amoako, Daniel Gyamfi; Allam, Mushal; Janice, Jessin; Pedersen, Torunn Annie; Sundsfjord, Arnfinn; Essack, Sabiha (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-23)
      <p><i>Objectives - </i>This study delineated the clonal lineages, antibiotic resistome and plasmid replicon types in multidrug-resistant <i>K. pneumoniae</i> isolates from a teaching hospital in Ghana. <p><i>Methods - </i>Identification and antibiotic susceptibility testing were done using the MALDI-TOF MS and Vitek-2 automated system. Genomic DNA extraction was carried out using the NucliSens ...
    • Design and Prestudy Assessment of a Dashboard for Presenting Self-Collected Health Data of Patients With Diabetes to Clinicians: Iterative Approach and Qualitative Case Study 

      Giordanengo, Alain; Årsand, Eirik; Woldaregay, Ashenafi Zebene; Bradway, Meghan; Grøttland, Astrid; Hartvigsen, Gunnar; Granja, Conceição; Torsvik, Torbjørn; Hansen, Anne Helen (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-09)
      <p><i>Background - </i>Introducing self-collected health data from patients with diabetes into consultation can be beneficial for both patients and clinicians. Such an initiative can allow patients to be more proactive in their disease management and clinicians to provide more tailored medical services. Optimally, electronic health record systems (EHRs) should be able to receive self-collected health ...
    • Integrating mental health into primary care in Arkhangelsk County, Russia: the Pomor model in psychiatry 

      Rezvy, Grigory; Andreeva, Elena; Ryzhkova, Nadezhda; Yashkovich, Vera; Sørlie, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-13)
      <p><i>Background - </i>Primary health care is still peripheral in the identification and treatment of mental health and substance use disorders in the Russian Federation. However, the development of primary health services has been given priority. A long-standing collaboration between Arkhangelsk County and northern Norway on mental health service development in Arkhangelsk has promoted the integration ...
    • The dsDNA, Anti-dsDNA Antibody, and Lupus Nephritis: What We Agree on, What Must Be Done, and What the Best Strategy Forward Could Be 

      Rekvig, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-15)
      This study aims to understand what lupus nephritis is, its origin, clinical context, and its pathogenesis. Truly, we encounter many conceptual and immanent tribulations in our attempts to search for the pathogenesis of this disease—and how to explain its assumed link to SLE. Central in the present landscape stay a short history of the early studies that substantiated the structures of isolated or ...
    • Do Various Respirator Models Fit the Workers in the Norwegian Smelting Industry? 

      Føreland, Solveig; Robertsen, Øystein; Hegseth, Marit Nøst (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-19)
      <p><i>Background - </i>Respirator fit testing is a method to assess if the respirator provides an adequate face seal for the worker. <p><i>Methods - </i>Workers from four Norwegian smelters were invited to participate in the study, and 701 respirator fit tests were performed on 127 workers. Fourteen respirator models were included: one FFABE1P3 and 11 FFP3 respirator models produced in one size and ...
    • Automatic Detection of Small Icebergs in Fast Ice Using Satellite Wide-Swath SAR Images 

      Soldal, Ingri Halland; Dierking, Wolfgang Fritz Otto; Korosov, Anton; Marino, Armando (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-03)
      Automatic detection of icebergs in satellite images is regarded a useful tool to provide information necessary for safety in Arctic shipping or operations over large ocean areas in near-real time. In this work, we investigated the feasibility of automatic iceberg detection in Sentinel-1 Extra Wide Swath (EWS) SAR images which follow the preferred image mode in operational ice charting. As test region, ...
    • Hva mener du om genmodifisert mat? 

      Bakkelund, Torill Pauline Blix (Others; Andre, 2019-09-22)
    • Clinical Course in Chronic Subdural Hematoma Patients Aged 18–49 Compared to Patients 50 Years and Above: A Multicenter Study and Meta-Analysis 

      Bartek, Jiri; Sjåvik, Kristin; Dhawan, Sanjay; Sagberg, Lisa Millgård; Kristiansson, Helena; Ståhl, Fredrik; Förander, Petter; Chen, Clark C.; Jakola, Asgeir Store (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-05)
      <p><i>Objective - </i>Chronic Subdural Hematoma (cSDH) is primarily a disease of elderly, and is rare in patients <50 years, and this may in part be related to the increased brain atrophy from 50 years of age. This fact may also influence clinical presentation and outcome. The aim of this study was to study the clinical course with emphasis on clinical presentation of cSDH patients in the young (<50 ...
    • Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency 

      Jørgensen, Silje Fjellgård; Macpherson, Magnhild Eide; Bjørnetrø, Tonje; Holm, Kristian; Kummen, Martin; Rashidi, Azita; Michelsen, Annika; Lekva, Tove; Halvorsen, Bente; Trøseid, Marius; Mollnes, Tom Eirik; Berge, Rolf Kristian; Yndestad, Arne; Ueland, Thor; Karlsen, Tom Hemming; Aukrust, Pål; Hov, Johannes Espolin Roksund; Fevang, Børre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-17)
      Common variable immunodeficiency (CVID) patients have reduced gut microbial diversity compared to healthy controls. The reduced diversity is associated with gut leakage, increased systemic inflammation and ten “key” bacteria that capture the gut dysbiosis (dysbiosis index) in CVID. Rifaximin is a broad-spectrum non-absorbable antibiotic known to reduce gut leakage (lipopolysaccharides, LPS) in liver ...
    • Paclitaxel-loaded biodegradable ROS-sensitive nanoparticles for cancer therapy 

      Pandya, Abhilash D.; Jäger, Eliézer; Fam, Shahla Bagheri; Höcherl, Anita; Jäger, Alessandro; Sincari, Vladimir; Nyström, Bo; Štěpánek, Petr; Skotland, Tore; Sandvig, Kirsten; Hrubý, Martin; Mælandsmo, Gunhild M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-06)
      <i>Background</i>: Reactive oxygen species (ROS), such as hydrogen peroxide and superoxide, trigger biodegradation of polymer-based nanoparticles (NPs) bearing pinacol-type boronic ester groups. These NPs may selectively release their cargo, in this case paclitaxel (PTX), at the high levels of ROS present in the intracellular environment of inflamed tissues and most tumors.<p> <p><i>Purpose</i>: ...
    • Sannhetskommisjoner. Om institusjonalisert kunnskap, kritisk distanse og andre antropologiske utfordringer 

      Saugestad, Sidsel (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-20)
      Denne artikkelen ser på noen aspekter av en sannhetskommisjon som er oppnevnt i Norge. Den første delen skisserer bakgrunnen for oppnevnelsen og diskuterer de argumentene som ble fremlagt, supplert med sitater fra en avisdebatt. Den andre delen setter denne debatten inn i en bredere sammenheng av norsk-samiske relasjoner og gir noen eksempler på samisk kommunikasjon om rett til å være forskjellig. ...
    • Differential expression of the miR-17-92 cluster and miR-17 family in breast cancer according to tumor type; results from the Norwegian Women and Cancer (NOWAC) study 

      Moi, Line; Braaten, Tonje; Al-Shibli, Khalid; Lund, Eiliv; Rasmussen Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-03)
      <i>Background</i> - MicroRNAs (miRNAs) are promising biomarkers due to their structural stability and distinct expression profile in various cancers. We wanted to explore the miRNA expression in benign breast tissue and breast cancer subgroups in the Norwegian Women and Cancer study.<p> <p><i>Methods</i> - Specimens and histopathological data from study participants in Northern Norway diagnosed ...
    • Allodia Winnertz from the Himalayas, with nine species new to science (Diptera, Mycetophilidae). 

      Magnussen, Trude; Søli, Geir Einar Ellefsen; Kjærandsen, Jostein (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-29)
      An extensive collection of fungus gnats from Nepal and Bhutan, deposited at Kyushu University Museum in Japan, has been examined and revealed nine species of <i>Allodia</i> Winnertz, 1864 new to science: <i>Allodia caligata</i> Magnussen, <b>sp. n.</b>, <i>A. dibolia</i> Magnussen, <b>sp. n.</b>, <i>A. shimai</i> Magnussen, <b>sp. n.</b>, <i>A. spathulata</i> Magnussen, <b>sp. n.</b>, <i>A. horologia</i> ...
    • Persistence of disseminated tumor cells after neoadjuvant treatment for locally advanced breast cancer predicts poor survival 

      Mathiesen, Randi Margit Ruud; Borgen, Elin; Renolen, Anne; Løkkevik, Erik; Nesland, Jahn M; Anker, Gun Birgitta; Østenstad, Bjørn; Lundgren, Steinar; Risberg, Terje; Mjaaland, Ingvil; Kvalheim, Gunnar; Lønning, Per Eystein; Naume, Bjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-08-14)
      <i>Introduction</i> - Presence of disseminated tumor cells (DTCs) in bone marrow (BM) and circulating tumor cells (CTC) in peripheral blood (PB) predicts reduced survival in early breast cancer. The aim of this study was to determine the presence of and alterations in DTC- and CTC-status in locally advanced breast cancer patients undergoing neoadjuvant chemotherapy (NACT) and to evaluate their ...
    • An integrated transcriptome analysis in T-cell acute lymphoblastic leukemia links DNA methylation subgroups to dysregulated TAL1 and ANTP homeobox gene expression 

      Haider, Zahra; larsson, Pär; Landfors, Mattias; Kohn, Linda; Schmiegelow, Kjeld; Flægstad, Trond; Kanerva, Jukka; Heyman, Mats; Hultdin, Magnus; Degerman, Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-21)
      Classification of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients into CIMP (CpG Island Methylator Phenotype) subgroups has the potential to improve current risk stratification. To investigate the biology behind these CIMP subgroups, diagnostic samples from Nordic pediatric T-ALL patients were characterized by genome-wide methylation arrays, followed by targeted exome sequencing, ...
    • Long-term effects on survival after a 1-year multifactorial vascular risk factor intervention after stroke or TIA: secondary analysis of a randomized controlled trial, a 7-year follow-up study 

      Hagberg, Guri; Fure, Brynjar; Sandset, Else Charlotte; Thommessen, Bente; Ihle-Hansen, Håkon; Øksengård, Anne Rita; Nygård, Ståle; Wyller, Torgeir Bruun; Ihle-Hansen, Hege (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-07)
      <p><i>Background - </i>Stroke and coronary heart disease share the same risk factors, and a multifactorial intervention after stroke may potentially result in the same reduction in cardiovascular mortality as seen after coronary events. We aimed to evaluate the effect on survival 7 years after a 1-year multifactorial risk factor intervention, and identify clinical predictors for long-term survival ...
    • La citation de données de recherche dans des publications en linguistique: L’histoire d’une initiative prise par la communauté scientifique 

      Andreassen, Helene N. (Conference object; Konferansebidrag, 2019-10-03)
      La création et la diffusion de la recherche reproductible reçoivent de plus en plus d’attention dans la discussion sur les meilleures pratiques de publication et d’enseignement. Un élément clé de ces pratiques constitue la citation appropriée des données de recherche. En 2017, un réseau de chercheurs, archivistes et bibliothécaires a fondé un groupe au sein de Research Data Alliance, Linguistics ...
    • Climatology of the mesopause relative density using a global distribution of meteor radars 

      Yi, Wen; Xue, Xianghui; Reid, Iain; Murphy, Damian J.; Hall, Chris; Tsutsumi, Masaki; Ning, Baiqi; Li, Guozhu; Vincent, Robert; Chen, Jinsong; Wu, Jianfei; Chen, Tingdi; Dou, Xiankang (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-06)
      The existing distribution of meteor radars located from high- to low-latitude regions provides a favorable temporal and spatial coverage for investigating the climatology of the global mesopause density. In this study, we report the climatology of the mesopause relative density estimated using multiyear observations from nine meteor radars, namely, the Davis Station (68.6∘ S, 77.9∘ E), Svalbard ...
    • A guided internet-delivered individually-tailored ACT-influenced cognitive behavioural intervention to improve psychosocial outcomes in breast cancer survivors (iNNOVBC): Study protocol 

      Mendes-Santos, Cristina; Weiderpass, Elisabete; Santana, Rui; Andersson, Gerhard (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-10)
      <p><i>Background - </i>Internet-delivered interventions can provide remarkable opportunities in addressing breast cancer survivors' unmet support care needs, as they present an effective strategy to improve care coordination and provide access to efficacious, cost-efficient and convenient survivorship care. Nevertheless, research focusing on improving survivors' psychosocial needs using internet-based ...