In the inherited metabolic disorder acute intermittent porphyria (AIP), high sugar intake prevents porphyric attacks due to the glucose effect and the following high insulin levels that may lower AIP disease activity. Insulin resistance is a known risk factor for periodontitis and sugar changes diabetogenic hormones and affects dental health. We hypothesized differences in homeostasis model ...

Background and Purpose: Physiotherapy, with an emphasis on high intensity, individually tailored, and person‐centered treatment, is an effective route for recovery after a stroke. No single approach, however, has been deemed paramount, and there is limited knowledge about the patient experience of assessment, goal‐setting, and treatment in physiotherapy. In this study, we seek to report patient ...

Background - Individuals with intellectual disability (ID) are less physically active, have a higher body mass index (BMI) and are at greater risk for cardiovascular diseases (CVDs) than people without ID. The purpose of the study was to explore the effectiveness of a web-based training programme, consisting of 150 min of activity per week, on the health of people with ID.<p> <p>Method - Participants ...

A growing consensus sees the bilingual lexicon as an integrated, nonselective system. However, the way bilingual experience shapes the architecture and functioning of the lexicon is not well understood. This study investigates bilingual lexical-semantic representation and processing employing written translation priming. We focus on the role of active exposure to and use of the second language ...

The correlation between in vivo and in vitro data is yet not sufficiently optimized to allow a significant reduction and replacement of animal testing in pharmaceutical development. One of the main reasons for this lies in the poor mechanistic understanding and interpretation of the physical mechanisms enabling formulation rely on for deploying the drug. One mechanism that still lacks a proper ...

This article examines social workers’ perceptions of youths’ participation and how their perceptions influence their practice towards youths in aftercare. The article is based on qualitative interviews with 38 social workers in child welfare services (CWS) and collaborative welfare services. The interviews were analysed using a hermeneutic approach. We identified two practices with different objectives: ...

Dagens bruk av verktøyet BioAlder for å finne sannsynlig aldersspenn hos asylsøkere er basert på en statistisk feilslutning. Mindreårige risikerer å klassifiseres som voksne.

Although chronic myeloid leukemia (CML) can be effectively treated using BCR‑ABL1 kinase inhibitors, resistance due to kinase alterations or to BCR‑ABL1 independent mechanisms remain a therapeutic challenge. For the latter, the underlying mechanisms are widely discussed; for instance, gene expression changes, epigenetic factors and alternative signaling pathway activation. In the present study, in ...

Background: The lungs are the organ most likely to sustain serious injury from coronavirus disease 2019 (COVID-19). However, the mechanisms for long-term complications are not clear. Patients with severe COVID-19 have shorter telomere lengths and higher levels of cellular senescence, and we hypothesized that circulating levels of the telomere-associated senescence markers chitotriosidase, ...

Avalanche decision-making falls into two general categories; probabilistic approaches and analytical approaches. Analytical approaches have traditionally been considered applicable to experts only, as they require assessing risk factors precisely and understanding their relevance in each situation. In this study we question this assumption. We asked 1,220 amateur backcountry recreationalists how ...