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dc.contributor.advisorBjørkedal, Espen
dc.contributor.authorVasylenko, Olena
dc.date.accessioned2013-05-16T07:17:58Z
dc.date.available2013-05-16T07:17:58Z
dc.date.issued2012-05-02
dc.description.abstractTranscranial direct current stimulation (tDCS) is a non-invasive neuromodulatory technique that can reduce pain. Its side effects are milder than those of pharmacological treatments, and its analgesic effect on chronic pain has been demonstrated. In this study we investigated 1) the effects of anodal tDCS on pain intensity and threshold, 2) the placebo component of tDCS analgesic effect, and 3) whether stress and negative affect moderate the analgesic effect of tDCS. Sixty-four participants (32 females) received three blocks of heat stimuli, 43° C, 45° C, and 47° C in each block. The treatment group received anodal tDCS of 2 mA intensity for 7 minutes, the placebo group received sham stimulation for 30 seconds, and the natural history group received painful stimuli only. Participants rated pain intensity with CoVAS. Threshold was measured before the first and after the last block. Subjective stress was measured by two SACL items, and negative affect was measured by FPQ, PANAS, and BFI questionnaires. Compared to no treatment, tDCS reduced pain by 28%, for 47° C stimuli only. Compared to sham stimulation, tDCS reduced pain by 11%, but this reduction was only marginally significant. There was no placebo response, and no effect of tDCS on pain threshold. Fear of medical pain predicted pain reduction by tDCS, higher fear of medical pain was associated with larger pain reduction. Our findings confirm and extend those of earlier experimental and clinical studies.en
dc.identifier.urihttps://hdl.handle.net/10037/5152
dc.identifier.urnURN:NBN:no-uit_munin_4866
dc.language.isoengen
dc.publisherUniversitetet i Tromsøen
dc.publisherUniversity of Tromsøen
dc.rights.accessRightsopenAccess
dc.rights.holderCopyright 2012 The Author(s)
dc.subject.courseIDPSY-3900en
dc.subjecttranscranial direct current stimulation, anodal, contact heat, fear of pain, pain threshold, placebo analgesia, painen
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260::Biologisk psykologi: 261en
dc.subjectVDP::Social science: 200::Psychology: 260::Biological psychology: 261en
dc.titleEffects of anodal transcranial direct current stimulation on experimentally induced heat pain in healthy volunteersen
dc.typeMaster thesisen
dc.typeMastergradsoppgaveen


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