Viser treff 2461-2480 av 5378

    • 1H, 13C, 15N resonance assignment of the apo form of the small, chitin-active lytic polysaccharide monooxygenase JdLPMO10A from Jonesia denitrificans 

      Christensen, Idd Andrea; Eijsink, Vincent; Aachmann, Finn Lillelund; Courtade, Gaston (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-19)
      The lytic polysaccharide monooxygenase <i>Jd</i>LPMO10A is the N-terminal domain of the multimodular protein Jd1381. The isolated <i>Jd</i>LPMO10A domain is one of the smallest chitin-active lytic polysaccharide monooxygenases known to date with a size of only 15.5 kDa. <i>Jd</i>LPMO10A is a copper-dependent oxidative enzyme that depolymerizes chitin by hydroxylating the C1 carbon in the glycosidic ...
    • Artefact removal in ground truth deficient fluctuations-based nanoscopy images using deep learning 

      Jadhav, Suyog; Acuña Maldonado, Sebastian Andres; Opstad, Ida Sundvor; Ahluwalia, Balpreet Singh; Agarwal, Krishna; Prasad, Dilip K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-08)
      Image denoising or artefact removal using deep learning is possible in the availability of supervised training dataset acquired in real experiments or synthesized using known noise models. Neither of the conditions can be fulfilled for nanoscopy (super-resolution optical microscopy) images that are generated from microscopy videos through statistical analysis techniques. Due to several physical ...
    • nsroot: Minimalist process isolation tool implemented with Linux namespaces 

      Raknes, Inge Alexander; Fjukstad, Bjørn; Bongo, Lars Ailo Aslaksen (Journal article; Tidsskriftartikkel, 2017-11-26)
      Data analyses in the life sciences are moving from tools run on a personal computer to services run on large computing platforms. This creates a need to package tools and dependencies for easy installation, configuration and deployment on distributed platforms. In addition, for secure execution there is a need for process isolation on a shared platform. Existing virtual machine and container ...
    • Selecting technological alternatives for regulatory compliance towards emissions reduction from shipping: An integrated fuzzy multi-criteria decision-making approach under vague environment 

      Bui, Khanh Q.; Ölçer, Aykut I.; Kitada, Momoko; Ballini, Fabio (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-01)
      Due to the increasing pressure from stricter environmental regulations to reduce emissions in shipping, the maritime industry has been striving for finding more effective measures. Existing measures are often not enough to comply with new regulations. Among various alternative measures, it is not easy for decision-makers (shipowners and operators) to choose the most suitable alternative measure as ...
    • Machine learning derived input-function in a dynamic 18F-FDG PET study of mice 

      Kuttner, Samuel; Wickstrøm, Kristoffer Knutsen; Kalda, Gustav; Dorraji, Seyed Esmaeil; Martin-Armas, Montserrat; Oteiza, Ana; Jenssen, Robert; Fenton, Kristin Andreassen; Sundset, Rune; Axelsson, Jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-13)
      Tracer kinetic modelling, based on dynamic <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is used to quantify glucose metabolism in humans and animals. Knowledge of the arterial input-function (AIF) is required for such measurements. Our aim was to explore two non-invasive machine learning-based models, for AIF prediction in a small-animal dynamic FDG PET study. 7 tissue ...
    • Photonic-chip based free space beam shaping and steering for advanced optical microscopy application 

      Lahrberg, Marcel; Dullo, Firehun Tsige; Ahluwalia, Balpreet Singh (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-12)
      Photonic-chip-based light illumination has recently found applications in optical microscopy and nanoscopy methodologies. The photonic chip removes the dependency on imaging objective lenses to generate the required illumination patterns for different microscopy methods. Until now, all the reported chip-based optical microscopy methods exploit the evanescent field present on top of a waveguide surface ...
    • HyperKvasir, a comprehensive multi-class image and video dataset for gastrointestinal endoscopy 

      Borgli, Hanna; Thambawita, Vajira; Smedsrud, Pia H; Hicks, Steven; Jha, Debesh; Eskeland, Sigrun Losada; Randel, Kristin Ranheim; Pogorelov, Konstantin; Lux, Mathias; Dang Nguyen, Duc Tien; Johansen, Dag; Griwodz, Carsten; Stensland, Håkon Kvale; Garcia-Ceja, Enrique; Schmidt, Peter T; Hammer, Hugo Lewi; Riegler, Michael; Halvorsen, Pål; de Lange, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-28)
      Artificial intelligence is currently a hot topic in medicine. However, medical data is often sparse and hard to obtain due to legal restrictions and lack of medical personnel for the cumbersome and tedious process to manually label training data. These constraints make it difficult to develop systems for automatic analysis, like detecting disease or other lesions. In this respect, this article ...
    • Drone-Mounted UWB Snow Radar: Technical Improvements and Field Results 

      Jenssen, Rolf-Ole Rydeng; Jacobsen, Svein Ketil (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-04)
      Drone borne radar systems have seen considerable advances over recent years, and the application of drone-mounted continuous wave (CW) radars for remote sensing of snow properties has great potential. Regardless, major challenges remain in antenna design for which both low weight and small size combined with high gain and bandwidth are important design parameters. Additional limiting factors for CW ...
    • Synthesis and molecular structure of perhalogenated rhenium-oxo corroles 

      Alemayehu, Abraham B.; Einrem, Rune F.; McCormick‑McPherson, Laura J.; Settineri, Nicholas S.; Ghosh, Abhik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-12)
      As part of our efforts to develop rhenium-oxo corroles as photosensitizers for oxygen sensing and photodynamic therapy, we investigated the potential <i>β</i>-perhalogenation of five ReO <i>meso</i>-tris(<i>para</i>-X-phenyl)corroles, Re[T<i>p</i>XPC](O) (X = CF<sub>3</sub>, H, F, CH<sub>3</sub>, and OCH<sub>3</sub>), with elemental chlorine and bromine. With Cl<sub>2</sub>, <i>β</i>-octachlorinated ...
    • Iridium corroles exhibit weak near-infrared phosphorescence but efficiently sensitize singlet oxygen formation 

      Ghosh, Abhik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-05)
      Six-coordinate iridium(III) triarylcorrole derivatives, Ir[T<i>p</i>XPC)]L<sub>2</sub>, where T<i>p</i>XPC = tris(para-X-phenyl)corrole (X = CF<sub>3</sub>, H, Me, and OCH<sub>3</sub>) and L = pyridine (py), trimethylamine (tma), isoquinoline (isoq), 4-dimethylaminopyridine (dmap), and 4-picolinic acid (4pa), have been examined, with a view to identifying axial ligands most conducive to near-infrared ...
    • Neural network based country wise risk prediction of COVID-19 

      Pal, Ratnabali; Sekh, Arif Ahmed; Kar, Samarjit; Prasad, Dilip K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-16)
      The recent worldwide outbreak of the novel coronavirus (COVID-19) has opened up new challenges to the research community. Artificial intelligence (AI) driven methods can be useful to predict the parameters, risks, and effects of such an epidemic. Such predictions can be helpful to control and prevent the spread of such diseases. The main challenges of applying AI is the small volume of data and the ...
    • Soft thresholding schemes for multiple signal classification algorithm 

      Acuña Maldonado, Sebastian Andres; Opstad, Ida Sundvor; Godtliebsen, Fred; Ahluwalia, Balpreet Singh; Agarwal, Krishna (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-28)
      Multiple signal classification algorithm (MUSICAL) exploits temporal fluctuations in fluorescence intensity to perform super-resolution microscopy by computing the value of a super-resolving indicator function across a fine sample grid. A key step in the algorithm is the separation of the measurements into signal and noise subspaces, based on a single user-specified parameter called the threshold. ...
    • Deep Generative Models in Credit Scoring 

      Andrade Mancisidor, Rogelio (Doctoral thesis; Doktorgradsavhandling, 2021-02-05)
      Banks need to develop effective credit scoring models to better understand the relationship between customer information and the customer's ability to repay the loan. The output of such a model is called the default probability and is used to rank loan applications in terms of their creditworthiness. The focus of this thesis is to develop novel credit scoring methodologies that solve well-known ...
    • Description of the uEMEP_v5 downscaling approach for the EMEP MSC-W chemistry transport model 

      Denby, Bruce; Gauss, Michael; Wind, Peter; Mu, Qing; Wærsted, Eivind Grøtting; Fagerli, Hilde; Valdebenito Bustamante, Alvaro Moises; Klein, Heiko (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)
      A description of the new air quality downscaling model – the urban EMEP (uEMEP) and its combination with the EMEP MSC-W model (European Monitoring and Evaluation Programme Meteorological Synthesising Centre West) – is presented. uEMEP is based on well-known Gaussian modelling principles. The uniqueness of the system is in its combination with the EMEP MSC-W model and the “local fraction” calculation ...
    • Unequivocal structure confirmation of a breitfussin analog by anisotropic NMR measurements 

      Ndukwe, Ikenna E.; Lam, Yu-hong; Pandey, Sunil Kumar; Haug, Bengt Erik; Bayer, Annette; Sherer, Edward C.; Blinov, Kirill A.; Williamson, R. Thomas; Isaksson, Johan; Reibarkh, Mikhail; Liu, Yizhou; Martin, Gary E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-21)
      Structural features of proton-deficient heteroaromatic natural products, such as the breitfussins, can severely complicate their characterization by NMR spectroscopy. For the breitfussins in particular, the constitution of the five-membered oxazole central ring cannot be unequivocally established via conventional NMR methods when the 4′-position is halogenated. The level of difficulty is exacerbated ...
    • Metastatic Breast Cancer and Pre-Diagnostic Blood Gene Expression Profiles—The Norwegian Women and Cancer (NOWAC) Post-Genome Cohort 

      Holsbø, Einar; Olsen, Karina Standahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-15)
      Breast cancer patients with metastatic disease have a higher incidence of deaths from breast cancer than patients with early-stage cancers. Recent findings suggest that there are differences in immune cell function between metastatic and non-metastatic cases, even years before diagnosis. We have analyzed whole blood gene expression by Illumina bead chips in blood samples taken using the PAXgene blood ...
    • X-ray crystal structure of Vibrio alkaline phosphatase with the non-competitive inhibitor cyclohexylamine 

      Ásgeirsson, Bjarni; Markússon, Sigurbjörn; Hlynsdóttir, Sigríður S.; Helland, Ronny; Hjörleifsson, Jens G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-15)
      <i>Background</i> - <i>Para</i>-nitrophenyl phosphate, the common substrate for alkaline phosphatase (AP), is available as a cyclohexylamine salt. Here, we report that cyclohexylamine is a non-competitive inhibitor of APs.<br><br> <i>Methods</i> - Cyclohexylamine inhibited four different APs. Co-crystallization with the cold-active <i>Vibrio</i> AP (VAP) was performed and the structure solved.<br><br> ...
    • Predicting breast cancer metastasis from whole-blood transcriptomic measurements 

      Holsbø, Einar; Perduca, Vittorio; Bongo, Lars Ailo; Lund, Eiliv; Birmelé, Etienne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-20)
      <i>Objective</i> - In this exploratory work we investigate whether blood gene expression measurements predict breast cancer metastasis. Early detection of increased metastatic risk could potentially be life-saving. Our data comes from the Norwegian Women and Cancer epidemiological cohort study. The women who contributed to these data provided a blood sample up to a year before receiving a breast ...
    • Exceptions to bed-controlled ice sheet flow and retreat from glaciated continental margins worldwide 

      Greenwood, Sarah L.; Simkins, Lauren M; Winsborrow, Monica; Bjarnadóttir, Lilja Rún (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-13)
      Projections of ice sheet behavior hinge on how ice flow velocity evolves and the extent to which marine-based grounding lines are stable. Ice flow and grounding line retreat are variably governed by the coupling between the ice and underlying terrain. We ask to what degree catchment-scale bed characteristics determine ice flow and retreat, drawing on paleo-ice sheet landform imprints from 99 sites ...
    • Homogeneous glacial landscapes can have high local variability of strontium isotope signatures: Implications for prehistoric migration studies 

      Thomsen, Erik; Andreasen, Rasmus; Rasmussen, Tine Lander (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-15)
      Increasingly, strontium (Sr) isotopes are used to distinguish locals and migrants in prehistoric studies, by measuring <sup>87</sup>Sr/<sup>86</sup>Sr in human remains and comparing these values to the distribution of the bioavailable <sup>87</sup>Sr/<sup>86</sup>Sr in the study area, often in surface water. However, it has recently been shown that agricultural lime can have a substantial impact on ...