Viser treff 4381-4400 av 5442

    • Discovery of Novel Inhibitor Scaffolds against the Metallo-beta-lactamase VIM-2 by Surface Plasmon Resonance (SPR) Based Fragment Screening 

      Christopeit, Tony; Carlsen, Trine Josefine Olsen; Helland, Ronny; Leiros, Hanna-Kirsti S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-17)
      Metallo-β-lactamase (MBL) inhibitors can restore the function of carbapenem antibiotics and therefore help to treat infections of antibiotic resistant bacteria. In this study, we report novel fragments inhibiting the clinically relevant MBL Verona integron-encoded metallo-β-lactamase (VIM-2). The fragments were identified from a library of 490 fragments using an orthogonal screening approach based ...
    • Infrared Thermal Signature Evaluation of a Pure Ice Block 

      Rashid, Taimur; Khawaja, Hassan Abbas; Edvardsen, Kåre; Mughal, Umair Najeeb (Conference object; Konferansebidrag, 2015-08-23)
      Marine operations in cold climates are subjected to heavy ice accretion, which can lead to heavy ice loads causing safety concerns. Atmospheric and sea spray icing can cause severe ice accretion on structures. Ice detection over the relatively larger surface area of marine platforms and vessels could be significant for ice mitigation and its removal in cold climates. A thermal ice signature ...
    • Holdbarhet på klippfisk. Vekst av rødmidd i klippfisk lagret ved forhøyede temperaturer (AP2) 

      Lorentzen, Grete Elisabeth; Johansen, Jørn-Owe; Breiland, Mette Serine Wesmajervi; Dahl, Reidun Wenche; Sandaker, Elin Kristianne; Ytterstad, Elinor (Research report; Forskningsrapport, 2016-02)
      I prosjektet «Holdbarhet på klippfisk» er det foretatt studier for å fastsette holdbarhet på klippfisk basert på vekst av rødmidd. Denne rapporten referer til studier hvor klippfisk er lagret ved forhøyede temperaturer. Rød misfarging skyldes vekst av rødmidd som er en ekstrem halofil bakterie og denne blir naturlig tilført fisken gjennom saltet. Emballert loins av klippfisk og flekket klippfisk ble ...
    • An optimised method for electrodialytic removal of heavy metals from harbour sediments 

      Pedersen, Kristine Bondo; Jensen, Pernille E.; Ottosen, Lisbeth M.; Lejon, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-10)
      A 2-compartment electrodialytic cell set-up for treatment of solid materials has in many respects proven superior to other types of cells in removing heavy metals from sediments. Most notably, remediation times were shorter, energy consumption was lower and higher removal efficiencies were observed. By employing multivariate modelling and investigating additional experimental variables, the ...
    • Digital Chronofiles of Life Experience 

      Gurrin, Cathal; Johansen, Håvard; Sødring, Thomas; Johansen, Dag (Chapter; Bokkapittel, 2015-02-28)
      Technology has brought us to the point where we are able to digitally sample life experience in rich multimedia detail, often referred to as lifelogging. In this paper we explore the potential of lifelogging for the digitisation and archiving of life experience into a longitudinal media archive for an individual. We motivate the historical archive potential for rich digital memories, enabling ...
    • Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface 

      Williamson, Adele Kim; Rothweiler, Ulli; Leiros, Hanna-Kirsti S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-01)
      DNA ligases are a structurally diverse class of enzymes which share a common catalytic core and seal breaks in the phosphodiester backbone of double-stranded DNA via an adenylated intermediate. Here, the structure and activity of a recombinantly produced ATP-dependent DNA ligase from the bacterium Psychromonas sp. strain SP041 is described. This minimal-type ligase, like its close homologues, ...
    • Limits to the quantification of local climate change 

      Chapman, Sandra; Stainforth, David A.; Watkins, Nicholas W. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-16)
      Abstract Wedemonstrate how the fundamental timescales of anthropogenic climate change limit the identification of societally relevant aspects of changes in precipitation.Weshow that it is nevertheless possible to extract, solely from observations, some confident quantified assessments of change at certain thresholds and locations. Maps of such changes, for a variety of hydrologically-relevant, ...
    • Crystal structure of the DNA polymerase III β subunit (β-clamp) from the extremophile Deinococcus radiodurans 

      Niiranen, Laila; Lian, Kjersti; Johnson, Kenneth A; Moe, Elin (Journal article; Tidsskriftartikkel, 2015-02-27)
      Background: Deinococcus radiodurans is an extremely radiation and desiccation resistant bacterium which can tolerate radiation doses up to 5,000 Grays without losing viability. We are studying the role of DNA repair and replication proteins for this unusual phenotype by a structural biology approach. The DNA polymerase III β subunit (β-clamp) acts as a sliding clamp on DNA, promoting the binding ...
    • Computer-aided decision support for melanoma detection applied on melanocytic and non-melanocytic skin lesions: a comparison of two systems based on automatic analysis of dermoscopic images 

      Møllersen, Kajsa; Kirchesch, Herbert M.; Zortea, Maciel; Schopf, Thomas Roger Griesbeck; Hindberg, Kristian; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
      Commercially available clinical decision support systems (CDSSs) for skin cancer have been designed for the detection of melanoma only. Correct use of the systems requires expert knowledge, hampering their utility for nonexperts. Furthermore, there are no systems to detect other common skin cancer types, that is, nonmelanoma skin cancer (NMSC). As early diagnosis of skin cancer is essential, there ...
    • Natural variability of benthic foraminiferal assemblages and metal concentrations during the last 150 years in the Ingøydjupet trough, SW Barents Sea. 

      Dijkstra, Noortje; Junttila, Juho; Husum, Katrine; Carroll, JoLynn; Hald, Morten (Journal article; Tidsskriftartikkel, 2015-12)
      While today the SW Barents Sea is a relatively un-impacted and uncontaminated area, industrial activities related to the petroleum industry are projected to increase in the coming decades. This makes the area a valuable natural laboratory to establish pre-impacted baselines as a precursor for future seabed monitoring programs. Here we present benthic foraminiferal assemblages and metal concentrations ...
    • Infrared Thermal Signature Evaluation of a Pure and Saline Ice for Marine Operations in Cold Climate 

      Rashid, Taimur; Khawaja, Hassan Abbas; Edvardsen, Kåre; Mughal, Umair Najeeb (Peer reviewed; Journal article; Tidsskriftsartikkel, 2015)
      Marine operations in cold climates are subjected to abundant ice accretion, which can lead to heavy ice loads over larger surface area. For safe and adequate operations on marine vessels over a larger area, remote ice detection and ice mitigation system can be useful. To study this remote ice detection option, lab experimentation was performed to detect the thermal gradient of ice with the infrared ...
    • Structural and biochemical characterization of VIM-26 shows that Leu224 has implications for the substrate specificity of VIM metallo-β-lactamases 

      Leiros, Hanna-Kirsti S.; Edvardsen, Kine Susann Waade; Bjerga, Gro Elin Kjæreng; Samuelsen, Ørjan (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-06)
      During the last decades antimicrobial resistance has become a global health problem. Metallo-β-lactamases (MBLs) which are broad-spectrum β-lactamases that inactivate virtually all β-lactams including carbapenems, are contributing to this health problem. In this study a novel MBL variant, termed VIM-26, identified in a Klebsiella pneumoniae isolate was studied. VIM-26 belongs to the Verona ...
    • Four-Component Relativistic Density Functional Theory Calculations of EPR g- and Hyperfine-Coupling Tensors Using Hybrid Functionals: Validation on Transition-Metal Complexes with Large Tensor Anisotropies and Higher-Order Spin-Orbit Effects 

      Gohr, Sebastian; Hrobárik, Peter; Repisky, Michal; Komorovsky, Stanislav; Ruud, Kenneth; Kaupp, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-04)
      The four-component matrix Dirac-Kohn-Sham (mDKS) implementation of EPR g- and hyperfine A-tensor calculations within a restricted kinetic balance framework in the ReSpect code has been extended to hybrid functionals. The methodology is validated for an extended set of small 4d1 and 5d1 [MEXn] q systems, and for a series of larger Ir(II) and Pt(III) d7 complexes (S=1/2) with particularly ...
    • Variability of present and past PAH concentrations in sediments of the SW Barents Sea 

      Junttila, Juho; Carroll, JoLynn; Dijkstra, Noortje (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-09)
      The concentration and distribution of polyaromatic hydrocarbons (PAHs) in surface and subsurface sediment samples from Tromsøflaket and Ingøydjupet, southwestern Barents Sea, were investigated in order to provide insight into the levels and origins of PAHs in a region with petroleum activities. PAH profiles in sediments were evaluated in context with sediment grain size and total organic carbon ...
    • Hon förebygger miljökatastrofer 

      Johansson, Malin; Avenius, Malin (Others; Andre, 2015)
      Det får inte hända. men om det ändå gör det behövs ny teknik för att mildra effekterna. Malin Johanssons forskning handlar om att förebygga miljökatastrofer, när oljebolagen söker sig allt längre in i Arktis.
    • Benchmarking two-photon absorption cross sections: performance of CC2 and CAM-B3LYP 

      Beerepoot, Maarten T. P.; Friese, Daniel Henrik; List, Nanna Holmgaard; Kongsted, Jacob; Ruud, Kenneth (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-25)
      We investigate the performance of CC2 and TDDFT/CAM-B3LYP for the calculation of two-photon absorption (TPA) strengths and cross sections and contrast our results to a recent coupled cluster equation-of-motion (EOM-EE-CCSD) benchmark study [K. D. Nanda and A. I. Krylov, J. Chem. Phys., 2015, 142, 064118]. In particular, we investigate whether CC2 TPA strengths are significantly overestimated compared ...
    • Structure, solvent, and relativistic effects on the NMR chemical shifts in square-planar transition-metal complexes: Assessment of DFT approaches 

      Vicha, Jan; Novotny, Jan; Straka, Michal; Repisky, Michal; Ruud, Kenneth; Komorovsky, Stanislav; Marek, Radek (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-25)
      The role of various factors (structure, solvent, and relativistic treatment) was evaluated for square-planar 4d and 5d transition-metal complexes. The DFT method for calculating the structures was calibrated using a cluster approach and compared to X-ray geometries, with the PBE0 functional (def2-TZVPP basis set) providing the best results, followed closely by the hybrid TPSSH and the MN12SX ...
    • Imaging Sea Ice Structure by Remote Sensing Sensors 

      Eltoft, Torbjørn; Doulgeris, Anthony Paul; Brekke, Camilla; Solbø, Stian; Gerland, Sebastian; Hanssen, Alfred (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-14)
      This paper will investigate how new developments in remote sensing and sensor technologies can be applied to image the structure of the sea ice surface. Both segmentation of multipolarimetric synthetic aperture radar images and strategies for the analyses of polarimetric SAR data of sea ice are addressed. The analysis is based on a Radarsat 2 PolSAR scene of from the Fram Strait in September ...
    • Investigating the role of residues W228 and Y233 in the structure and activity of the GIM-1 metallo-beta-lactamase. 

      Skagseth, Susann; Carlsen, Trine Josefine Olsen; Bjerga, Gro Elin Kjæreng; Spencer, James; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-07)
      Metallo--lactamases (MBLs) hydrolyze virtually all -lactam antibiotics, including penicillins, cephalosporins, and carbapenems. The worldwide emergence of antibiotic-resistant bacteria harboring MBLs poses an increasing clinical threat. The MBL German imipenemase-1 (GIM-1) possesses an active site that is narrower and more hydrophobic than the active sites of other MBLs. The GIM-1 active-site ...
    • Characterization of a waveguide Mach-Zehnder interferometer using PDMS as a cover layer 

      Lindecrantz, Susan Mariah; Tinguely, Jean-Claude; Ahluwalia, Balpreet Singh; Hellesø, Olav Gaute (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
      A Mach-Zehnder interferometer made with shallow rib waveguides is studied experimentally and using simulations. The rib-height giving single-mode guidance is found as function of core thickness and polarization. Devices have been made using shallow rib waveguides (5 nm rib height) in silicon nitride. The sensitivity and the limit of detection (LOD) is studied experimentally regarding the length of ...