Susceptibility for Lupus Nephritis by low copy number of the FCGR3B gene is linked to increased levels of pathogenic autoantibodies
ForfatterNossent, Johannes C; Becker-Merok, Andrea; Rischmueller, Maureen; Lester, Sue
Low copy number (CN) of the FCGR3B gene reduces FCGR3B membrane expression on neutrophils and results in clearance of a smaller amount of immune complex. We investigated FCGR3B CN in relation to the clinical phenotype in a Caucasian SLE cohort (𝑛 = 107). FCGR3B CN was determined by three different qPCR parameter estimations (Ct−, Cy0, and cpD1) and confirmed by the FCGR2C/FCGR2A paralog ratio test. Clinical and serological data were then analyzed for their association with FCGR3B CN. Low FCGR3B CN (<2) was more frequent in SLE patients than in healthy controls (𝑛 = 162) (20% versus 6%, OR 4.15, 𝑃 = 0.003) and associated with higher disease activity scores (SLEDAI 10.4 versus 6.1, 𝑃 = 0.03), lupus nephritis (LN) (25 versus 5%, 𝑃 = 0.03), and increased levels of antibodies against dsDNA (81 versus 37 IU, 𝑃 = 0.03), C1q (22 versus 6 IU, 𝑃 = 0.003), and ribosomal P (10 versus 5 IU, 𝑃 = 0.01). No such associations were seen with antibodies against extractable nuclear antigens or high FCGR3B CN (>2). In multivariate analyses, LN was independently associated with anti-C1q-Ab levels (𝑃 = 0.03) and low FCGR3B CN (𝑃 = 0.09). We conclude that the susceptibility for LN in patients with low FCGR3B CN is linked to increased levels of pathogenic autoantibodies.
ForlagHindawi Publishing Corporation
SiteringAutoimmune Diseases (2013), Article ID 750814, 6 pages
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