Latent semantic variables are associated with formal thought disorder and adaptive behavior in older inpatients with schizophrenia
ForfatterHolshausen, Katherine; Harvey, Philip D.; Elvevåg, Brita; Foltz, Peter; Bowie, Christopher R.
Introduction: Formal thought disorder is a hallmark feature of schizophrenia in which disorganized thoughts manifest as disordered speech. A dysfunctional semantic system and a disruption in executive functioning have been proposed as possible mechanisms for formal thought disorder and verbal fluency impairment. Traditional rating scales and neuropsychological test scores might not be sensitive enough to distinguish among types of semantic impairments. This has lead to the proposed used of a natural language processing technique, Latent Semantic Analysis (LSA), which offers improved semantic sensitivity. Method: In this study, LSA, a computational, vector-based text analysis technique to examine the contribution of vector length, an LSA measure related to word unusualness and cosines between word vectors, an LSA measure of semantic coherence to semantic and phonological fluency, disconnectedness of speech, and adaptive functioning in 165 older inpatients with schizophrenia. Results: In stepwise regressions word unusualness was significantly associated with semantic fluency and phonological fluency, disconnectedness in speech, and impaired functioning, even after considering the contribution of premorbid cognition, positive and negative symptoms, and demographic variables. Conclusions: These findings support the utility of LSA in examining the contribution of coherence to thought disorder and the its relationship with daily functioning. Deficits in verbal fluency may be an expression of underlying disorganization in thought processes.
SiteringCortex (2013), online before print
Følgende lisensfil er knyttet til denne innførselen:
Viser innførsler relatert til tittel, forfatter og emneord.
Voorspoels, Wouter; Storms, Gert; Longenecker, Julia; Verheyen, Steven; Weinberger, Daniel R.; Elvevåg, Brita (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Assessing verbal output in category fluency tasks provides a sensitive indicator of cortical dysfunction. The most common metrics are the overall number of words produced and the number of errors. Two main observations have been made about the structure of the output, first that there is a temporal component to it with words being generated in spurts, and second that the clustering pattern may reflect ...
Subjective sleeping problems and selfreported sleep length during four seasons in arctic Northern Norway Skre, Ingunn; Braathen, Tonje; Hansen, Vidje; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
A five-year prospective follow-up of longstanding eating disorders : influence from personality disorders and child sexual abuse Vrabel, KariAnne R. (Doctoral thesis; Doktorgradsavhandling, 2010-05-05)Follow-up studies have shown that 20-30% of patients with eating disorders develop longstanding symptoms seriously impairing their daily life. There are very few studies on the course of these patients. <br>This dissertation consists of three papers on patients admitted to a specialized inpatient treatment program at the Modum Bad psychiatric hospital. The participants were assessed upon admission, ...