• Development of UHPLC-MS/MS methods to quantify 25 antihypertensive drugs in serum in a cohort of patients treated for hypertension 

      Thorstensen, Christian W.; Clasen, Per-Erik; Rognstad, Stine; Haldsrud, Renate; Føreid, Siri; Helstrøm, Trine; Bergland, Ola Undrum; Halvorsen, Lene Vernås; Aune, Arleen; Olsen, Erik; Brobak, Karl Marius; Høieggen, Aud; Gustavsen, Ingebjørg G.; Larstorp, Anne Cecilie Kjeldsen; Søraas, Camilla Lund; Opdal, Mimi Stokke (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-23)
      We developed three ultra-high pressure liquid chromatography coupled to mass spectrometry detection (UHPLCMS/MS) methods to quantify 25 antihypertensive drugs in serum samples. Patient-reported drug lists were collected, and drug concentrations were analysed in samples from 547 patients, half with uncontrolled hypertension, and all treated with ≥ 2 antihypertensive drugs. For sample preparation, ...
    • Gender differences in association between uric acid and all-cause mortality in patients with chronic heart failure 

      Stubnova, Viera; Os, Ingrid; Høieggen, Aud; Solbu, Marit Dahl; Grundtvig, Morten; Westheim, Arne; Atar, Dan; Waldum-Grevbo, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-05)
      <p><i>Background - </i>Elevated serum uric acid (SUA) is associated with poor prognosis in patients with cardiovascular disease, yet it is still not decided whether the role of SUA is causal or only reflects an underlying disease. The purpose of the study was to investigate if SUA was an independent predictor of 5-year all-cause mortality in a propensity score matched cohort of chronic heart failure ...