Blar i forfatter Artikler, rapporter og annet (klinisk medisin) "Nager Grifo, Mireia"

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    • ATPase activity of DFCP1 controls selective autophagy 

      Nahse-Kumpf, Viola; Raiborg, Camilla; Tan, Kia Wee; Mørk, Sissel; Torgersen, Maria Lyngaas; Wenzel, Eva; Nager Grifo, Mireia; Salo, Veijo T.; Johansen, Terje; Ikonen, Elina; Schink, Kay Oliver; Stenmark, Harald Alfred (Journal article; Tidsskriftartikkel, 2023-07-08)
      Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped regions of the endoplasmic reticulum (ER) known as omegasomes, which are characterized by the presence of the ER protein DFCP1/ZFYVE1. The function of DFCP1 is unknown, as are the mechanisms ...

    • High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts 

      Godtliebsen, Gustav; Larsen, Kenneth Bowitz; Bhujabal, Zambarlal Babanrao; Opstad, Ida Sundvor; Nager Grifo, Mireia; Punnakkal, Abhinanda Ranjit; Kalstad, Trine; Olsen, Randi; Lund, trine; Prasad, Dilip K.; Agarwal, Krishna; Myrmel, Truls; Birgisdottir, Åsa birna (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-05)
      Mitochondria are susceptible to damage resulting from their activity as energy providers. Damaged mitochondria can cause harm to the cell and thus mitochondria are subjected to elaborate quality-control mechanisms including elimination via lysosomal degradation in a process termed mitophagy. Basal mitophagy is a house-keeping mechanism fine-tuning the number of mitochondria according to the metabolic ...