Kjellin, Midori; Kileng, Hege; Akaberi, Dario; Palanisamy, Navaneethan; Duberg, Ann-Sofi; Danielsson, Astrid; Kristiansen, Magnhild Gangsøy; Nöjd, Johan Edvin; Aleman, Soo; Gutteberg, Tore Jarl; Goll, Rasmus; Lannergård, Anders; Lennerstrand, Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-19)
<i>Background</i>: The NS5A resistance-associated substitution (RAS) Y93H is found quite frequently (5–10%) at baseline in direct-acting antiviral agents (DAA) treatment-naïve genotype (GT) 3a patients when studied by the population-sequencing method (cut-off 20%). This RAS may impair HCV DAA treatment response, since it possesses a high fold <i>in vitro</i> resistance to daclatasvir (DCV) and ...