Blar i forfatter Artikler, rapporter og annet (klinisk medisin) "Sager, Georg"

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    • Altered pharmacological effects of adrenergic agonists during hypothermia 

      Dietrichs, Erik Sveberg; Sager, Georg; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-05)
      Rewarming from accidental hypothermia is often complicated by hypothermia-induced cardiac dysfunction, calling for immediate pharmacologic intervention. Studies show that although cardiac pharmacologic support is applied when rewarming these patients, a lack of updated treatment recommendations exist. Mainly due to lack of clinical and experimental data, neither of the international guidelines ...

    • Expression of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) in the human endometrium after 6 months levonorgestrel low dose intrauterine therapy 

      Sletten, Elise Thoresen; Smaglyukova, Natalia; Ørbo, Anne; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-29)
      The classical steroid receptors (nuclear receptors), including those for progesterone (nPRs), are thoroughly characterized. The knowledge about so-called non-genomic effects, which are mediated by extra-nuclear initiated signals, has increased immensely the last decades. In a previous clinical study of endometrial hyperplasia, we observed that the antiproliferative progestin effect persisted after ...

    • Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding 

      Amundsen, Siri; Nordeng, Hedvig; Nordeng, Hedvig Marie Egeland; Fuskevåg, Ole Martin; Nordmo, Elisabet; Nordmo, Elisabet N; Sager, Georg; Spigset, Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-17)
      Clinical data on the transfer of triptans into human breast milk remain scarce. In a lactation study including 19 breastfeeding women with migraine, we examined the excretion of six different triptans into milk. Following intake of a single dose, each participant collected seven breast milk samples at predefined intervals up to 24 hours after dose. Triptan concentrations in milk were measured using ...

    • Vasopressin impairs brain, heart and kidney perfusion: an experimental study in pigs after transient myocardial ischemia 

      Müller, Stig; How, Ole-Jakob; Hermansen, Stig Eggen; Stenberg, Thor Allan; Sager, Georg; Myrmel, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-02-21)
      Introduction: Arginine vasopressin (AVP) is increasingly used to restore mean arterial pressure (MAP) in low-pressure shock states unresponsive to conventional inotropes. This is potentially deleterious since AVP is also known to reduce cardiac output by increasing vascular resistance. The effects of AVP on blood flow to vital organs and cardiac performance in a circulation altered by cardiac ...