Artikler, rapporter og annet (klinisk medisin): Recent submissions
Now showing items 141-160 of 1804
-
Considerations regarding carotid artery dose in radiotherapy of the cervical spine
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-08)Radiation to the carotid arteries, e.g. in the context of head and neck cancer treatment, is one of several risk factors for artery stenosis. In principle, this fact may also have implications for stereotactic cervical spine radiotherapy, because long-term survival can be achieved in patients with oligometastatic disease and favorable prognostic features. Here, we suggest that radiation dose ... -
Independent Validation of a Unifying Prognostic Model for Intracranial and Extracranial Metastasis-directed Radiotherapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-06)We present the first calculations of the heavy flavor diffusion coefficient using lattice QCD with light dynamical quarks corresponding to a pion mass of around 320 MeV. For temperatures 195 MeV <T< 352 MeV, the heavy quark spatial diffusion coefficient is found to be significantly smaller than previous quenched lattice QCD and recent phenomenological estimates. The result implies very fast ... -
Characteristics and outcomes of patients who did not respond to a national spine surgery registry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-04)Background Loss to follow-up may bias outcome assessments in medical registries. This cohort study aimed to analyze and compare patients who failed to respond with those that responded to the Norwegian Registry for Spine Surgery (NORspine).<p> <p>Methods We analyzed a cohort of 474 consecutive patients operated for lumbar spinal stenosis at four public hospitals in Norway during a two-year period. ... -
Nord og ned?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-29)I sykehustalen for 2023 ba helseministeren Helse Nord om å sikre «bærekraften» fordi den økonomiske situasjonen er prekær. Dette brukes nå for å legitimere strukturelle endringer som vil endre helsetjenesten i nord dramatisk. -
C-reactive protein levels and depression in older and younger adults - A study of 19,947 individuals. The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-17)In recent years, a connection between depression and inflammation has been established, with a range of immunological changes, both cellular and humoral, presenting during depressive states (Beydoun et al., 2016; Haapakoski et al., 2015; Wium-Andersen et al., 2013). Furthermore, there seems to be a dose-response relationship between depression and inflammation, in the sense that the more severe the ... -
Percent of remaining life on palliative radiation treatment: solely a function of fractionation?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-14)Background: This study analyzed the percent of remaining life (PRL) on treatment in patients irradiated for bone metastases. Bone metastases were treated together with other target volumes, if indicated, e.g. a 10-fraction treatment course that included brain and bone metastases. PRL was determined by calculating the time between start and finish of palliative radiotherapy (minimum 1 day in case of ... -
Inflammatory Biomarkers Can Differentiate Acute Lymphoblastic Leukemia with Arthropathy from Juvenile Idiopathic Arthritis Better Than Standard Blood Tests
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-04)Objective - To evaluate the predictive value of biomarkers of inflammation like phagocyte-related S100 proteins and a panel of inflammatory cytokines in order to differentiate the child with acute lymphoblastic leukemia (ALL) from juvenile idiopathic arthritis (JIA).<p> <p>Study design - In this cross-sectional study, we measured S100A9, S100A12, and 14 cytokines in serum from children with ALL ... -
Neurological and respiratory effects of lung protective ventilation in acute brain injury patients without lung injury: brain vent, a single centre randomized interventional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-20)Introduction - Lung protective ventilation (LPV) comprising low tidal volume (VT) and high positive end-expiratory pressure (PEEP) may compromise cerebral perfusion in acute brain injury (ABI). In patients with ABI, we investigated whether LPV is associated with increased intracranial pressure (ICP) and/or deranged cerebral autoregulation (CA), brain compensatory reserve and oxygenation.<p> <p>Methods ... -
Cohesive collisions of particles in liquid media studied by CFD-DEM, video tracking, and Positron Emission Particle Tracking
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-18)This paper investigates the cohesive collision of ice in an oil phase at temperatures ranging from −15.7 °C to −0.3 °C. The new information on the coefficient of restitution (COR) was obtained using three different velocity measurement methods: high-speed experimental video recording, Positron Emission Particle Tracking (PEPT), and numerical simulations. A new type of PEPT tracer was developed for ... -
Reflections on measuring disordered thoughts as expressed via language
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-06)Thought disorder, as inferred from disorganized and incoherent speech, is an important part of the clinical presentation in schizophrenia. Traditional measurement approaches essentially count occurrences of certain speech events which may have restricted their usefulness. Applying speech technologies in assessment can help automate traditional clinical rating tasks and thereby complement the ... -
Intestinal fatty acid binding protein is associated with cardiac function and gut dysbiosis in chronic heart failure
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-02)Background: The gut microbiota in patients with chronic heart failure (HF) is characterized by low bacterial diversity and reduced ability to synthesize beneficial metabolites. These changes may facilitate leakage of whole bacteria or bacterial products from the gut into the bloodstream, which may activate the innate immune system and contribute to the low-grade inflammation seen in HF. In this ... -
Optimized workflow to modify microRNA expression in primary human intravascular cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-15)Background - A comprehensive dissection of the role of microRNAs (miRNAs) in gene regulation and subsequent cell functions requires a specific and efficient knockdown or overexpression of the miRNA of interest; these are achieved by transfecting the cell of interest with a miRNA inhibitor or a miRNA mimic, respectively. Inhibitors and mimics of miRNAs with a unique chemistry and/or structural ... -
The effect of selective ultrasound screening on the incidence of late presentation of developmental hip dysplasia—a meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-26)Different screening strategies for developmental dysplasia of the hip (DDH) exist. Despite screening efforts, cases of late presentation continue to occur, often necessitating surgery. This systematic review and meta-analysis assess the effect of newborn selective ultrasound screening for DDH on the incidence of late presentation in infants and children, compared to a universal ultrasound strategy. ... -
The Role of Preoperative Inflammatory Markers in Pancreatectomy: a Norwegian Nationwide Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-15)Background and purpose Preoperative infammatory markers, such as Glasgow prognostic score, modifed Glasgow prognostic score and C-reactive protein to albumin ratio, were shown to be associated with prognosis in patients undergoing pancreatectomy for cancer. However, little is known about their predictive role in a Western population.<p> <p>Methods The Norwegian National Registry for Gastrointestinal ... -
Continuous positive airway pressure in cluster headache: A randomized, placebo-controlled, triple-blind, crossover study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-09)Background - Oxygen inhalation aborts cluster headache attacks, and case reports show the effect of continuous positive airway pressure. The aim of this study was to investigate the prophylactic effect of continuous positive airway pressure in chronic cluster headache.<p> <p>Methods - This was a randomized placebo-controlled triple-blind crossover study using active and sham continuous positive ... -
Association of physical activity with overall mortality among long-term testicular cancer survivors: A longitudinal study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-19)Physical activity (PA) has been associated with reduced mortality among cancer survivors, but no study has focused on testicular cancer survivors (TCSs). We aimed to investigate the association of PA measured twice during survivorship with overall mortality in TCSs. TCSs treated during 1980 to 1994 participated in a nationwide longitudinal survey between 1998 to 2002 (S1: n = 1392) and 2007 to 2009 ... -
Opposite and dynamic regulation of the interferon response in metastatic and non-metastatic breast cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-07)Background To our current understanding, solid tumors depend on suppressed local immune reactions, often elicited by the interaction between tumor cells and tumor microenvironment (TME) components. Despite an improved understanding of anti-cancer immune responses in the TME, it is still unclear how immuno-suppressive TME are formed and how some cancer cells survive and metastasize.<p> <p>Methods ... -
Prompt closure versus gradual weaning of external ventricular drainage for hydrocephalus following aneurysmal subarachnoid haemorrhage: Protocol for the DRAIN randomised clinical trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-10)Background: Aneurysmal subarachnoid haemorrhage (aSAH) is a life-threatening disease caused by rupture of an intracranial aneurysm. A common complication following aSAH is hydrocephalus, for which placement of an external ventricular drain (EVD) is an important first-line treatment. Once the patient is clinically stable, the EVD is either removed or replaced by a ventriculoperitoneal shunt. The ... -
Hand grip strength in venous thromboembolism: risk of recurrence and mortality
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-29)Background - There is limited information on the relationship between muscle strength and recurrence and mortality after incident venous thromboembolism (VTE).<p> <p>Objectives - To investigate whether weak hand grip strength (HGS) was associated with risk of recurrence and mortality in patients with VTE recruited from the general population.<p> <p>Methods - Participants from the Tromsø Study ... -
Radiographic markers of hip dysplasia in young adults: predictive effect of factors in early life
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-11)Background and objectives Acetabular dysplasia in young adults occurs, despite screening for developmental hip dysplasia (DDH) in the neonatal period. We aimed to examine how early life factors predict radiographic measurements of acetabular dysplasia at 18–19 years of age.<p> <p>Methods From a previous randomized trial (n=12,014; 1988–90) evaluating the role of hip ultrasound in newborn screening ...