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norskArtikler, rapporter og annet (klinisk medisin): Recent submissions
Now showing items 141-160 of 1920
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Homologous Recombination Deficiency Across Subtypes of Primary Breast Cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-01)Purpose - Homologous recombination deficiency (HRD) is highly prevalent in triple-negative breast cancer (TNBC) and associated with response to PARP inhibition (PARPi). Here, we studied the prevalence of HRD in non-TNBC to assess the potential for PARPi in a wider group of patients with breast cancer.<p> <p>Methods - HRD status was established using targeted gene panel sequencing (360 genes) and ... -
Er legerollen uforenlig med dødshjelp?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023)En problemstilling idødshjelpsdeba en er hvordan dødshjelp kan forenes etisk med rollen som helsepersonell, og spesielt med rollen som behandlende lege. Andelen leger som stø er legalisering av dødshjelp er økende, og en prosess for åavklare legens mulige oppgaver ved livets slu er derfor betimelig. Legeyrket innebærer ere faglige roller, en av dem er åvære sakkyndig. Vi skisserer en hypotetisk ... -
Lifestyle interventions to change trajectories of obesity-related cardiovascular risk from childhood onset to manifestation in adulthood: a joint scientific statement of the task force for childhood health of the European Association of Preventive Cardiology and the European Childhood Obesity Group
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-25)There is an immediate need to optimize cardiovascular (CV) risk management and primary prevention of childhood obesity to timely and more effectively combat the health hazard and socioeconomic burden of CV disease from childhood development to adulthood manifestation. Optimizing screening programs and risk management strategies for obesity-related CV risk in childhood has high potential to change ... -
Including measures of chronic kidney disease to improve cardiovascular risk prediction by SCORE2 and SCORE2-OP
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-16)Aims - The 2021 European Society of Cardiology (ESC) guideline on cardiovascular disease (CVD) prevention categorizes moderate and severe chronic kidney disease (CKD) as high and very-high CVD risk status regardless of other factors like age and does not include estimated glomerular filtration rate (eGFR) and albuminuria in its algorithms, systemic coronary risk estimation 2 (SCORE2) and systemic ... -
Variation in antibiotic consumption in very preterm infants-a 10 year population-based study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-21)Objectives: Wide variations in antibiotic use in very preterm infants have been reported across centres despite similar rates of infection. We describe 10 year trends in use of antibiotics and regional variations among very preterm infants in Norway. Patients and Methods: All live-born very preterm infants (<32 weeks gestation) admitted to any neonatal unit in Norway during 2009–18 were included. ... -
Transcatheter aortic valve implantation (from inception to standard treatment): a single-center observational study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-15)Background: Treatment of severe aortic stenosis with transcatheter aortic valve implantation (TAVI) was introduced in 2002. Since then, TAVI has become the primary treatment approach worldwide for advanced-age patients and younger patients with severe comorbidities. We aimed to evaluate the changes in patient demographics, complications, and mortality rates within 13 years.<p> <p>Methods: This ... -
Automatic measurements of left ventricular volumes and ejection fraction by artificial intelligence: clinical validation in real time and large databases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-26)Aims - Echocardiography is a cornerstone in cardiac imaging, and left ventricular (LV) ejection fraction (EF) is a key parameter for patient management. Recent advances in artificial intelligence (AI) have enabled fully automatic measurements of LV volumes and EF both during scanning and in stored recordings. The aim of this study was to evaluate the impact of implementing AI measurements on acquisition ... -
Automatic measurements of left ventricular volumes and ejection fraction by artificial intelligence reduces time-consumption and inter-observer variability
(Conference object; Konferansebidrag, 2023-06-19) -
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-09)Background - The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with different modes of action.<p> <p>Methods - Investigator-initiated, randomised, blinded-assessor study. Patients with treatment-naïve early RA with moderate–severe disease activity ... -
Long-Term Results After Surgery for Degenerative Cervical Myelopathy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-20)BACKGROUND AND OBJECTIVES: Degenerative cervical myelopathy (DCM) is a frequent cause of spinal cord dysfunction, and surgical treatment is considered safe and effective. Long-term results after surgery are limited. This study investigated long-term clinical outcomes through data from the Norwegian registry for spine surgery.<p> <p>METHODS: Patients operated at the university hospitals serving ... -
Follow-Up of Patients With Axial Spondyloarthritis in Specialist Health Care With Remote Monitoring and Self-Monitoring Compared With Regular Face-to-Face Follow-Up Visits (the ReMonit Study): Protocol for a Randomized, Controlled Open-Label Noninferiority Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-27)Background: Patients with chronic inflammatory joint diseases such as axial spondyloarthritis have traditionally received regular follow-up in specialist health care to maintain low disease activity. The follow-up has been organized as prescheduled face-to-face visits, which are time-consuming for both patients and health care professionals. Technology has enabled the remote monitoring of disease ... -
Description of the prehospital emergency healthcare system in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-23)Background: Norway has a long coastline, steep mountains, and wide fjords, which presents some challenges to the prehospital emergency healthcare system. In recent years, the prehospital emergency medical services (EMS) have undergone significant changes, structurally, in terms of professionalisation of the services and in the education level of the personnel. In this article, we aim to describe the ... -
Incidence of bleeding and recurrence in isolated distal deep vein thrombosis: findings from the Venous Thrombosis Registry in Østfold Hospital
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-30)Background - Isolated distal deep vein thrombosis (IDDVT) is a common presentation of deep vein thrombosis. There are limited data on the long-term risk of recurrence after IDDVT.<p> <p>Objectives - We aimed to determine the short- and long-term incidence of venous thrombosis (VTE) recurrence after cessation of anticoagulation and the 3-month incidence of bleeding during anticoagulant treatment ... -
Serum Markers of Neuronal Damage and Astrocyte Activity in Patients with Chronic Epilepsy: Elevated Levels of Glial Fibrillary Acidic Protein
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-07)Objectives. Blood-brain barrier (BBB) dysfunction is one of the key pathogenic mechanisms in the development of epilepsy. There is therefore an increasing need to identify BBB biomarkers as these will have prognostic and therapeutic implications. The purpose of this study was to assess the levels of the BBB permeability markers, glial fibrillary acidic protein (GFAP), neuron-specific enolase ... -
Nasjonal anbefaling for utredning og behandling av døgnrytmelidelser
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023)Nasjonal kompetansetjeneste for søvnsykdommer (fra 2023: Nasjonalt senter for søvnmedisin) nedsatte høsten 2022 en arbeidsgruppe for å utvikle en nasjonal anbefaling for utredning og behandling av døgnrytmelidelser. Gruppen bestod av personer med ulik yrkesbakgrunn (allmennlege, psykolog, psykiater, klinisk nevrofysiolog, fysiolog, sykepleier), som alle har forskningskompetanse innen fagområdet. ... -
No effect of omega-3 polyunsaturated fatty acid supplementation on inflammatory markers in familial hypercholesterolemia: a randomized crossover trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-31)Individuals with familial hypercholesterolemia (FH) have increased cardiovascular risk despite lipid-lowering therapy, and additional therapy is warranted. Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplements have demonstrated an effect on cardiovascular endpoints in some clinical trials. Platelet-modifying and anti-inflammatory properties are among the proposed beneficial effects of n-3 PUFA. ... -
Reflections on the nature of measurement in language-based automated assessments of patients' mental state and cognitive function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-22)Modern advances in computational language processing methods have enabled new approaches to the measurement of mental processes. However, the field has primarily focused on model accuracy in predicting performance on a task or a diagnostic category. Instead the field should be more focused on determining which computational analyses align best with the targeted neurocognitive/psychological functions ... -
Maternal mortality related to pulmonary embolism in the United States, 2003–2020
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-23)BACKGROUND - Pulmonary embolism is a leading cause of maternal morbidity and mortality in Western countries. In the United States, pulmonary embolism–related mortality rates have plateaued in the general population after an initial decrease in the past 20 years.<p> <p>OBJECTIVE - This study aimed to describe the changes in pulmonary embolism–related maternal mortality rates in the United States ... -
Does it make sense to use written instruments to assess communication skills? Systematic review on the concurrent and predictive value of written assessment for performance
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-23)Objectives - To evaluate possible associations between learners’ results in written and performance-based assessments of communication skills (CS), either in concurrent or predictive study designs.<p> <p>Methods - Search included four databases for peer-reviewed studies containing both written and performance-based CS assessment. Eleven studies met the inclusion criteria.<p> <p>Results - ... -
Incidence of venous thromboembolism, recurrence, and bleeding after isolated superficial vein thrombosis: findings from the Venous Thrombosis Registry in Østfold Hospital
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-31)Background - There are limited data on the long-term risk of venous thromboembolism (VTE) after high-risk isolated superficial vein thrombosis (iSVT) treated with anticoagulants.<p> <p>Objectives - To determine the short- and long-term risk of VTE and iSVT recurrence after cessation of anticoagulant treatment and to calculate 45-day cumulative bleeding incidence in patients with iSVT.<p> <p>Methods ...
