Now showing items 301-320 of 1974

    • Epidemiology and Antimicrobial Susceptibility of Invasive Bacterial Infections in Children—A Population-Based Study From Norway 

      Thaulow, Christian Magnus; Lindemann, Paul Christoffer; Klingenberg, Claus; Berild, Dag; Blix, Hege Salvesen; Myklebust, Tor Åge; Harthug, Stig (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05)
      Objective: To describe epidemiology and antimicrobial susceptibility testing (AST) data of bacteria causing invasive infections in Norwegian children (0–18 years).<p> <p>Methods: Population-based observational study using prospectively collected AST data from the Norwegian Surveillance System of Antimicrobial Resistance from 2013 to 2017. We included all clinically relevant bacterial isolates ...
    • Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis 

      Chemaly, Melody; Marlevi, David; Iglesias, Maria Jesus; Lengquist, Mariette; Kronqvist, Malin; Bos, Daniel; van Dam-Nolen, Dianne H. K.; van der Kolk, Anja; Hendrikse, Jeroen; Kassem, Mohamed; Matic, Ljubica; Odeberg, Jacob; de Vries, Margreet R.; Kooi, M. Eline; Hedin, Ulf (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-24)
      Background: Intraplaque hemorrhage (IPH) is a hallmark of atherosclerotic plaque instability. Biliverdin reductase B (BLVRB) is enriched in plasma and plaques from patients with symptomatic carotid atherosclerosis and functionally associated with IPH. Objective: We explored the biomarker potential of plasma BLVRB through (1) its correlation with IPH in carotid plaques assessed by magnetic resonance ...
    • Prospects of returning to work after lumbar spine surgery for patients considering disability pension: A nationwide study based on data from the Norwegian Registry for Spine Surgery 

      Hammer, Lovise; Ingebrigtsen, Tor; Gulati, Sasha; Hara, Sozaburo; Nygaard, Øystein Petter; Hara, Karen Walseth; Solberg, Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-09)
      Objectives To assess the odds for not returning to work (non-RTW) 1 year after treatment among patients who had applied for or were planning to apply for disability pension (DP-applicant) prior to an operation for degenerative disorders of the lumbar spine.<p> <p>Methods This population-based cohort study from the Norwegian Registry for Spine surgery included 26 688 cases operated for ...
    • S100A8 gene copy number and protein expression in breast cancer: associations with proliferation, histopathological grade and molecular subtypes 

      Børkja, Mathieu; Giambelluca, Miriam Soledad; Ytterhus, Borgny; Prestvik, Wenche Slettahjell; Bjørkøy, Geir; Bofin, Anna M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-14)
      Background and aims Amplification of S100A8 occurs in 10–30% of all breast cancers and has been linked to poorer prognosis. Similarly, the protein S100A8 is overexpressed in a roughly comparable proportion of breast cancers and is also found in infiltrating myeloid-lineage cells, again linked to poorer prognosis. We explore the relationship between these findings.<p> <p>Methods We examined S100A8 ...
    • Is the presence of foraminal stenosis associated with outcome in lumbar spinal stenosis patients treated with posterior microsurgical decompression 

      Aaen, Jørn Ståle; BANITALEBI, HASAN; Austevoll, Ivar Magne; Hellum, Christian; Storheim, Kjersti; Myklebust, Tor Åge; Anvar, Masoud D; Weber, Clemens; Solberg, Tore; Grundnes, Oliver; Brisby, Helena; Indrekvam, Kari; Hermansen, Erland (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-05)
      Background We aim to investigate associations between preoperative radiological findings of lumbar foraminal stenosis with clinical outcomes after posterior microsurgical decompression in patients with predominantly central lumbar spinal stenosis (LSS).<p> <p>Methods The study was an additional analysis in the NORDSTEN Spinal Stenosis Trial. In total, 230 men and 207 women (mean age 66.8 (SD ...
    • The Norwegian degenerative spondylolisthesis and spinal stenosis (NORDSTEN) study: study overview, organization structure and study population 

      Indrekvam, Kari; Bånerud, Ingrid Fjeldheim; Hermansen, Erland; Austevoll, Ivar Magne; Rekeland, Frode Gurvin; Guddal, Maren Hjelle; Solberg, Tore; Brox, Jens Ivar; Hellum, Christian; Storheim, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-03)
      Purpose To provide an overview of the The Norwegian Degenerative spondylolisthesis and spinal stenosis (NORDSTEN)- study and the organizational structure, and to evaluate the study population.<p> <p>Methods The NORDSTEN is a multicentre study with 10 year follow-up, conducted at 18 public hospitals. NORDSTEN includes three studies: (1) The randomized spinal stenosis trial comparing the impact of ...
    • Laterale ankelligamentskader 

      Brun, Ole-Christian L.; Stødle, Are Haukåen; Molund, Marius; Hvaal, Kjetil (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-13)
      Laterale ankelligamentskader oppstår i forbindelse med inversjonstraumer og er en av de vanligste skadene både i den generelle befolkningen og blant aktive idrettsutøvere. En lateral ankelligamentskade svekker stabiliserende strukturer i ankelen og kan disponere for vedvarende instabilitet i ankelleddet. Akutte laterale ankelligamentskader uten mistanke om brudd kan behandles og følges opp konservativt ...
    • Anti-apoptotic genes and non-coding RNAs are potential outcome predictors for ulcerative colitis 

      Meng, Wei; Johnsen, Kay-Martin; Fenton, Christopher Graham; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-18)
      Due to the lack of clinical, immunologic, genetic, and laboratory markers to predict remission in ulcerative colitis (UC) without relapse, there is no clear recommendation regarding withdrawal of therapy. Therefore, this study was to investigate if transcriptional analysis together with Cox survival analysis might be able to reveal molecular markers that are specific for remission duration and ...
    • Glioblastom hos voksne 

      Schipmann, Stephanie; Sivakanesan, Sarankan; Rath, Daniel Stavne; Brandal, Petter; Vik-Mo, Einar Osland; Bjørås, Magnar; Solheim, Ole Skeidsvoll; Ingebrigtsen, Tor; Sund, Fredrik; Bjerkvig, Rolf; Miletic, Hrvoje; Johannessen, Tor-Christian Aase; Sundstrøm, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-30)
      Glioblastom er den vanligste formen for primær hjernekreft hos voksne, og sykdommen har en alvorlig prognose. Selv om det er gjort store fremskritt i molekylær karakteristikk, har det ikke vært større gjennombrudd i behandlingen på mange år. Vi presenterer her en klinisk oversikt over dagens diagnostikk og behandling samt hvilke utfordringer og muligheter som ligger i å utvikle bedre og mer ...
    • Cancer-associated fibroblasts in radiotherapy: Bystanders or protagonists? 

      Martinez, Inigo Zubiavrre; Hellevik, Turid (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-11)
      Background - The primary goal of radiotherapy (RT) is to induce cellular damage on malignant cells; however, it is becoming increasingly recognized the important role played by the tumor microenvironment (TME) in therapy outcomes. Therapeutic irradiation of tumor lesions provokes profound cellular and biological reconfigurations within the TME that ultimately may influence the fate of the ...
    • Considerations regarding carotid artery dose in radiotherapy of the cervical spine 

      Nieder, Carsten; Grant, David McKenzie (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-08)
      Radiation to the carotid arteries, e.g. in the context of head and neck cancer treatment, is one of several risk factors for artery stenosis. In principle, this fact may also have implications for stereotactic cervical spine radiotherapy, because long-term survival can be achieved in patients with oligometastatic disease and favorable prognostic features. Here, we suggest that radiation dose ...
    • Independent Validation of a Unifying Prognostic Model for Intracranial and Extracranial Metastasis-directed Radiotherapy 

      Nieder, Carsten; Stanisavljevic, Luka; Mannsåker, Bård; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-06)
      We present the first calculations of the heavy flavor diffusion coefficient using lattice QCD with light dynamical quarks corresponding to a pion mass of around 320 MeV. For temperatures 195 MeV <T< 352 MeV, the heavy quark spatial diffusion coefficient is found to be significantly smaller than previous quenched lattice QCD and recent phenomenological estimates. The result implies very fast ...
    • Characteristics and outcomes of patients who did not respond to a national spine surgery registry 

      Kaur, Simran; Alhaug, Ole Kristian; Dolatowski, Filip Celestyn; Solberg, Tore; Lønne, Greger (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-04)
      Background Loss to follow-up may bias outcome assessments in medical registries. This cohort study aimed to analyze and compare patients who failed to respond with those that responded to the Norwegian Registry for Spine Surgery (NORspine).<p> <p>Methods We analyzed a cohort of 474 consecutive patients operated for lumbar spinal stenosis at four public hospitals in Norway during a two-year period. ...
    • Nord og ned? 

      Agledahl, Kari Milch; Wisborg, Torben (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-29)
      I sykehustalen for 2023 ba helseministeren Helse Nord om å sikre «bærekraften» fordi den økonomiske situasjonen er prekær. Dette brukes nå for å legitimere strukturelle endringer som vil endre helsetjenesten i nord dramatisk.
    • C-reactive protein levels and depression in older and younger adults - A study of 19,947 individuals. The Tromsø study 

      Bugge, Erlend; Wynn, Rolf; Mollnes, Tom Eirik; Reitan, Solveig Merete Klæbo; Lapid, Maria I.; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-17)
      In recent years, a connection between depression and inflammation has been established, with a range of immunological changes, both cellular and humoral, presenting during depressive states (Beydoun et al., 2016; Haapakoski et al., 2015; Wium-Andersen et al., 2013). Furthermore, there seems to be a dose-response relationship between depression and inflammation, in the sense that the more severe the ...
    • Percent of remaining life on palliative radiation treatment: solely a function of fractionation? 

      Nieder, Carsten; Mannsåker, Bård; Dalhaug, Astrid (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-14)
      Background: This study analyzed the percent of remaining life (PRL) on treatment in patients irradiated for bone metastases. Bone metastases were treated together with other target volumes, if indicated, e.g. a 10-fraction treatment course that included brain and bone metastases. PRL was determined by calculating the time between start and finish of palliative radiotherapy (minimum 1 day in case of ...
    • Inflammatory Biomarkers Can Differentiate Acute Lymphoblastic Leukemia with Arthropathy from Juvenile Idiopathic Arthritis Better Than Standard Blood Tests 

      Brix, Ninna; Glerup, Mia; Foell, Dirk; Kessel, Christoph; Wittkowski, Helmut; Berntson, Lillemor; Fasth, Anders; Nielsen, Susan; Nordal, Ellen Berit; Rygg, Marite; Hasle, Henrik; Herlin, Troels (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-04)
      Objective - To evaluate the predictive value of biomarkers of inflammation like phagocyte-related S100 proteins and a panel of inflammatory cytokines in order to differentiate the child with acute lymphoblastic leukemia (ALL) from juvenile idiopathic arthritis (JIA).<p> <p>Study design - In this cross-sectional study, we measured S100A9, S100A12, and 14 cytokines in serum from children with ALL ...
    • Neurological and respiratory effects of lung protective ventilation in acute brain injury patients without lung injury: brain vent, a single centre randomized interventional study 

      Beqiri, Erta; Smielewski, Peter; Guérin, Claude; Czosnyka, Marek; Robba, Chiara; Bjertnæs, Lars Jakob; K Frisvold, Shirin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-20)
      Introduction - Lung protective ventilation (LPV) comprising low tidal volume (VT) and high positive end-expiratory pressure (PEEP) may compromise cerebral perfusion in acute brain injury (ABI). In patients with ABI, we investigated whether LPV is associated with increased intracranial pressure (ICP) and/or deranged cerebral autoregulation (CA), brain compensatory reserve and oxygenation.<p> <p>Methods ...
    • Cohesive collisions of particles in liquid media studied by CFD-DEM, video tracking, and Positron Emission Particle Tracking 

      Saparbayeva, Nazerke; Chang, Yu-Fen; Kosinski, Pawel Jan; hoffmann, alex christian; Balakin, Boris; Struchalin, Pavel (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-18)
      This paper investigates the cohesive collision of ice in an oil phase at temperatures ranging from −15.7 °C to −0.3 °C. The new information on the coefficient of restitution (COR) was obtained using three different velocity measurement methods: high-speed experimental video recording, Positron Emission Particle Tracking (PEPT), and numerical simulations. A new type of PEPT tracer was developed for ...
    • Reflections on measuring disordered thoughts as expressed via language 

      Elvevåg, Brita (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-06)
      Thought disorder, as inferred from disorganized and incoherent speech, is an important part of the clinical presentation in schizophrenia. Traditional measurement approaches essentially count occurrences of certain speech events which may have restricted their usefulness. Applying speech technologies in assessment can help automate traditional clinical rating tasks and thereby complement the ...