Artikler, rapporter og annet (klinisk medisin): Recent submissions
Now showing items 1-20 of 1805
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Repeat expansions in AR, ATXN1, ATXN2 and HTT in Norwegian patients diagnosed with amyotrophic lateral sclerosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-14)Genetic repeat expansions cause neuronal degeneration in amyotrophic lateral sclerosis as well as other neurodegenerative disorders such as spinocerebellar ataxia, Huntington’s disease and Kennedy’s disease. Repeat expansions in the same gene can cause multiple clinical phenotypes. We aimed to characterize repeat expansions in a Norwegian amyotrophic lateral sclerosis cohort. Norwegian amyotrophic ... -
Age and healthy lifestyle behavior’s disparities and similarities on knowledge of myocardial infarction symptoms and risk factors among public and outpatients in a resource-limited setting, cross-sectional study in greater Gaborone, Botswana
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-04)Objectives In this cross-sectional study from Botswana, we investigated knowledge of myocardial infarction (MI) symptoms and risk factors among the general public and outpatients with MI risk factors based on age and lifestyle behaviors, in addition to assessing associations with sociodemographic and MI risk factors.<p> <p>Method Open-ended questionnaires about 8 MI symptoms and 10 risk factors, ... -
User satisfaction with child and adolescent mental health services: the association between user satisfaction and clinical outcomes
(Journal article; Tidsskriftartikkel, 2024-04-15)<p><i>Background - </i>This study aimed to examine the association between user satisfaction and clinical outcomes with child and adolescent mental health services (CAMHS) from the perspective of young people and their parents. The evidence bases for CAMHS user satisfaction measures are limited, with few studies investigating the link between user satisfaction and clinical outcomes. In particular, ... -
Brief Intervention as a Method to Reduce Z-Hypnotic Use by Older Adults: Feasibility Case Series
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-08)Background: Z-hypnotics or z-drugs are commonly prescribed for insomnia and sleep difficulties in older adults. These drugs are associated with adverse events and dependence and are not recommended for long-term use. Despite evidence of older adults being more sensitive to a wide array of adverse events and clinical guidelines advocating limiting use, inappropriate use in this population is still ... -
Cytokines in hepatitis C-infected patients with or without opioid maintenance therapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-04)Objective: Both chronic hepatitis C virus (HCV) infection and opioids cause altered blood levels of cytokines. Previous studies have investigated levels of selected groups of cytokines in patients on opioid maintenance treatment. Little is known about the levels of multiple cytokines in patients with chronic HCV infection on opioid maintenance treatment. Our aim was to investigate the cytokine profile ... -
Metacognitive beliefs, mood symptoms, and fatigue four years after stroke: An explorative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-25)Objective - This cross-sectional study investigated the relationship between metacognition and mood symptoms four years post-stroke and examined fatigue as a potential moderator for this relationship.<p> <p>Methods - A number of 143 participants completed a survey that included the Hospital Anxiety and Depression Scale (HADS), the Metacognition Questionnaire-30 (MCQ-30), the Fatigue Severity Scale ... -
Impact of physiotherapy access on health-related quality of life following hip fracture: an observational study on 30 752 hip fractures from the Norwegian Hip Fracture Register 2014–2018
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-06)Objectives - The main objective of this study was to investigate the characteristics of patients receiving private community physiotherapy (PT) the first year after a hip fracture. Second, to determine whether utilisation of PT could improve health-related quality of life (HRQoL).<p> <p>Methods - In an observational cohort study, 30 752 hip fractures from the Norwegian Hip Fracture Register were ... -
Challenges in Defining a Reference Set of Differentially Expressed lncRNAs in Ulcerative Colitis by Meta-Analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-05)The study aimed to identify common differentially expressed lncRNAs from manually curated ulcerative colitis (UC) gene expression omnibus (GEO) datasets. Nine UC transcriptomic datasets of clearly annotated human colonic biopsies were included in the study. The datasets were manually curated to select active UC samples and controls. R packages geneknitR, gprofiler, clusterProfiler were used for gene ... -
Real-time feedback on chest compression efficacy by hands-free carotid Doppler in a porcine model
(Journal article; Tidsskriftartikkel, 2024-02-20)Aim: Current guidelines for cardiopulmonary resuscitation (CPR) recommend a one-size-fits-all approach in relation to the positioning of chest compressions. We recently developed RescueDoppler, a hands-free Doppler ultrasound device for continuous monitoring of carotid blood flow velocity during CPR. The aim of the present study is to investigate whether RescueDoppler via real-time hemodynamic ... -
VRD versus VCD as induction therapy before autologous stem cell transplantation in multiple myeloma: a nationwide population-based study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-09)Induction therapy followed by autologous stem cell transplantation (ASCT) is standard of care for young and fit patients with newly diagnosed multiple myeloma (MM) [1]. Induction therapy has evolved from doublet to triplet to quadruplet regimens over the last decades. The most common triplet therapy is either Bortezomib-Cyclophosphamide-Dexamethasone (VCD), Bortezomib-Lenalidomide-Dexamethasone ... -
Natural language processing markers for psychosis and other psychiatric disorders: emerging themes and research agenda from a cross-linguistic workshop
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-22)This workshop summary on natural language processing (NLP) markers for psychosis and other psychiatric disorders presents some of the clinical and research issues that NLP markers might address and some of the activities needed to move in that direction. We propose that the optimal development of NLP markers would occur in the context of research efforts to map out the underlying mechanisms of ... -
Labor curves based on cervical dilatation over time and their accuracy and effectiveness: A systematic scoping review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-22)Objectives - This systematic scoping review was conducted to 1) identify and describe labor curves that illustrate cervical dilatation over time; 2) map any evidence for, as well as outcomes used to evaluate the accuracy and effectiveness of the curves; and 3) identify areas in research that require further investigation.<p> <p>Methods - A three-step systematic literature search was conducted for ... -
What do adults living with obesity want from a chatbot for physical activity? – a qualitative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-21)Background - Regular physical activity helps to reduce weight and improve the general well-being of individuals living with obesity. Chatbots have shown the potential to increase physical activity among their users. We aimed to explore the preferences of individuals living with obesity for the features and functionalities of a modern chatbot based on social media, Artificial intelligence (AI) and ... -
Validation of eGFR for Detecting Associations Between Serum Protein Biomarkers and Subsequent GFR Decline
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08)Significance Statement - eGFR from creatinine, cystatin C, or both has been primarily used in search of biomarkers for GFR decline. Whether the relationships between biomarkers and eGFR decline are similar to associations with measured GFR (mGFR) decline has not been investigated. This study revealed that some biomarkers showed statistically significant different associations with eGFR decline ... -
Investigation of background contribution from different solvent brands used for sample preparation and analysis of persistent organic pollutants
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023)In the times of pandemic, we experienced problems with supply bottlenecks for the solvents normally used for extraction and analysis of persistent organic pollutants (POPs; i.e. PCBs, PBDEs and organochlorine pesticides) in our laboratory and, considered to start using solvents from another producer alternatively. Since we analyze POPs at very low concentration levels and other consumables are ... -
Mental health, challenging behaviour, diagnosis, and access to employment for people with intellectual disabilities in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-09)Background: Studies have found that presence of challenging behaviours and mental health problems limits employment for people with intellectual disabilities. This study investigates the associations between age, gender, living condition, level of intellec tual disability, diagnoses, behaviour, mental health, and employment in adults with intellectual disabilities in Norway.<p> <p>Method: A ... -
Small and large fiber neuropathy in adults with Myotonic dystrophy type 1
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-05)Introduction: Myotonic dystrophy type 1 (DM1) is an inherited neuromuscular disorder that affects multiple organs. In this study, we investigated symptoms of pain and presence of small and large fiber neuropathy in the juvenile and adult form of DM1.<p> <p>Method: Twenty genetically verified DM1 patients were included. Pain was assessed, and neurological examination and investigations of ... -
Protocol of a randomised, controlled trial comparing immediate curative therapy with conservative treatment in men aged ≥75 years with non-metastatic high-risk prostate cancer (SPCG 19/GRand-P)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-12)Background Older men (aged ≥75 years) with high risk, non-metastatic prostate cancer (PCa) are increasingly treated with curative therapy (surgery or radiotherapy). However, it is unclear if curative therapy prolongs life and improves health-related quality of life (HRQoL) in this age group compared to conservative therapy, which has evolved considerably during the last decade.<p> <p>Study ... -
Persistent Use of Prescription Opioids Before and After Lumbar Spine Surgery: Observational Study With Prospectively Collected Data From Two Norwegian National Registries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-15)Study Design - Prospective pharmacoepidemiologic study.<p> <p>Objective - To investigate clinical and sociodemographic factors associated with persistent opioid use in the years following spine surgery among patients with persistent opioid use preceding lumbar spine surgery.<p> <p>Summary of Background Data - It is unknown whether successful spine surgery leads to a cessation of preoperative ... -
Cystatin C-Based Equation to Estimate GFR without the Inclusion of Race and Sex
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-26)BACKGROUND - The accuracy of estimation of kidney function with the use of routine metabolic tests, such as measurement of the serum creatinine level, has been controversial. The European Kidney Function Consortium (EKFC) developed a creatinine-based equation (EKFC eGFRcr) to estimate the glomerular filtration rate (GFR) with a rescaled serum creatinine level (i.e., the serum creatinine level is ...