Recent additions

  • Persistent level of mental distress in PTSD patients is not reflected in cytokine levels 1 year after the treatment 

    Toft, Helge; Bramness, Jørgen Gustav; Tilden, Terje; Bolstad, Ingeborg; Lien, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-27)
    <i>Objective</i>: Cross-sectional data show that post-traumatic stress disorder (PTSD) patients often have increased levels of circulating inflammatory markers. There is, however, still a paucity of longitudinal studies with long follow-up times on levels of cytokines in such patients. The current study assesses patients with and without PTSD diagnosis 1 year after discharge from inpatient ...
  • Blood Pressure Treatment in Kidney Transplant Recipients - Can We Improve? 

    Onsøien, Mari Olsen; Midtvedt, Karsten; Reisæter, Anna Varberg; Aasarød, Knut; Waldum-Grevbo, Bård; Vikse, Bjørn Egil; Eriksen, Bjørn Odvar; Åsberg, Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-25)
    <i>Background</i> - Hypertension in kidney transplant (KTx) recipients is common, affecting both patient and graft survival. Annual data from the Norwegian Renal Registry reveal that <50% of adult (>18 y) KTx recipients reach target blood pressure (BP) ≤130/80 mm Hg. The aim of this study was to identify the determinants of failure to achieve BP control.<br><br> <i>Methods</i> - In conjunction ...
  • How common is substandard obstetric care in adverse events of birth asphyxia, shoulder dystocia and postpartum hemorrhage? Findings from an external inspection of Norwegian maternity units 

    Johansen, Lars Thomas; Braut, Geir Sverre; Acharya, Ganesh; Andresen, Jan Fredrik; Øian, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-15)
    Introduction - The Norwegian Board of Health Supervision inspects healthcare institutions to ensure safety and quality of health and welfare services. A planned inspection of 12 maternity units aimed to investigate the practice of obstetric care in the case of birth asphyxia, shoulder dystocia and severe postpartum hemorrhage.<p> <p>Material and methods - The inspection was carried out at two ...
  • HPyV6 and HPyV7 in urine from immunocompromised patients 

    Prezioso, Carla; Van Ghelue, Marijke; Moens, Ugo; Pietropaolo, Valeria (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-22)
    Background - Human polyomavirus 6 (HPyV6) and HPyV7 are two of the novel polyomaviruses that were originally detected in non-diseased skin. Serological studies have shown that these viruses are ubiquitous in the healthy adult population with seroprevalence up to 88% for HPyV6 and 72% for HPyV7. Both viruses are associated with pruritic skin eruption in immunocompromised patients, but a role with ...
  • DNA Damage Response 

    Oksenych, Valentyn; Kainov, Denis (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-19)
  • Fatigue in young adults with juvenile idiopathic arthritis 18 years after disease onset: data from the prospective Nordic JIA cohort 

    Arnstad, Ellen Dalen; Glerup, Mia; Rypdal, Veronika Gjertsen; Peltoniemi, Suvi; Fasth, Anders; Nielsen, Susan; Zak, Marek; Aalto, Kristiina; Berntson, Lillemor; Nordal, Ellen Berit; Herlin, Troels; Romundstad, Pål Richard; Rygg, Marite (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-12)
    Background: To study fatigue in young adults with juvenile idiopathic arthritis (JIA) 18 years after disease onset, and to compare with controls. Methods: Consecutive children with onset of JIA between 1997 and 2000, from geographically defined areas of Norway, Sweden, Denmark and Finland were followed for 18 years in a close to population-based prospective cohort study. Clinical features, ...
  • DNA hypo-methylation facilitates anti-inflammatory responses in severe ulcerative colitis 

    Taman, Hagar; Fenton, Christopher Graham; Anderssen, Endre; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-01)
    Severe ulcerative colitis (UC) is a potentially life-threatening disease with a potential colorectal cancer (CRC) risk. The aim of this study was to explore the relationship between transcriptomic and genome-wide DNA methylation profiles in a well-stratified, treatment-naïve severe UC patient population in order to define specific epigenetic changes that could be responsible for the grade of disease ...
  • The changing alcohol drinking patterns among older adults show that women are closing the gender gap in more frequent drinking: The Tromsø Study, 1994 – 2016 

    Stelander, Line Tegner; Høye, Anne; Bramness, Jørgen Gustav; Selbæk, Geir; Lunde, Linn Heidi; Wynn, Rolf; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-26)
    Background - As the population of older adults continues to grow, changes in alcohol consumption are important to monitor because an increase may have public health consequences. Rates of alcohol use vary with geographical location. The aim of this study was to examine trends in alcohol consumption among older adults in a geographically defined area in Norway, especially changing sex differences in ...
  • Severe hypercalcemia caused by parathyroid hormone in a rectal cancer metastasis: a case report 

    Brun, Vegard Heimly; Knutsen, Erik; Stenvold, Helge; Halvorsen, Hanne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-07)
    Background - Hypercalcemia of malignancy is relatively common in several cancers. However, in colorectal cancer, paraneoplastic phenomena that cause hypercalcemia is uncommon. In the few cases that are reported, secretion of parathyroid hormone-related peptide mediates the effect. We describe the first case of severe hypercalcemia mediated by intact parathyroid hormone secretion from a bone metastasis ...
  • Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study 

    Bekkelund, Svein Ivar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-13)
    Background - High and low levels of serum alanine aminotransferase (ALT) are both associated with cardiovascular diseases (CVD) risks especially in elderly, but the mechanisms are less known. This study investigated associations between ALT and CVD risk factors including effects of sex and age in a Caucasian population.<p> <p>Methods - Cross-sectional data were analysed sex-stratified in 2555 men ...
  • IgE-mediated peanut allergy: Current and novel predictive biomarkers for clinical phenotypes using multi-omics approaches 

    Czolk, Rebecca; Klueber, Julia; Sørensen, Martin; Wilmes, Paul; Codreanu-Morel, Françoise; Skov, Per Stahl; Hilger, Christiane; Bindslev-Jensen, Carsten; Ollert, Markus; Kuehn, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-28)
    Food allergy is a collective term for several immune-mediated responses to food. IgE-mediated food allergy is the best-known subtype. The patients present with a marked diversity of clinical profiles including symptomatic manifestations, threshold reactivity and reaction kinetics. In-vitro predictors of these clinical phenotypes are evasive and considered as knowledge gaps in food allergy diagnosis ...
  • Tenecteplase in wake-up ischemic stroke trial: Protocol for a randomized-controlled trial 

    Roaldsen, Melinda Berg; Lindekleiv, Haakon; Eltoft, Agnethe; Jusufovic, Mirza; Søyland, Mary-Helen; Petersson, Jesper; Indredavik, Bent; Tveiten, Arnstein; Putaala, Jukka; Christensen, Hanne; Kõrv, Janika; Jatužis, Dalius; Engelter, Stefan T.; Marco De Marchis, Gian; Wilsgaard, Tom; Werring, David; Robinson, Thompson; Mathiesen, Ellisiv B.; Berge, Eivind (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-14)
    <p>Background: Patients with wake-up ischemic stroke who have evidence of salvageable tissue on advanced imaging can benefit from intravenous thrombolysis. It is not known whether patients who do not fulfil such imaging criteria might benefit from treatment, but studies indicate that treatment based on non-contrast CT criteria may be safe. Tenecteplase has shown promising results in patients with ...
  • Ionizing radiation curtails immunosuppressive effects from cancer-associated fibroblasts on dendritic cells 

    Berzaghi, Rodrigo; Tornaas, Stian; Lode, Kristin; Hellevik, Turid; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-09)
    Cancer-associated fibroblasts (CAFs) participate actively in tumor development and affect treatment responses, by among other mechanisms, promoting an immunosuppressive tumor microenvironment. In contrast to normal fibroblasts, reactive CAFs secrete a myriad of immunomodulatory soluble factors at high levels, i.e. growth factors, cytokines, and chemokines, which directly influence tumor immunity and ...
  • Detection of quebec polyomavirus dna in samples from different patient groups 

    Prezioso, Carla; Van Ghelue, Marijke; Pietropaolo, Valeria; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-18)
    Polyomaviruses infect many species, including humans. So far, 15 polyomaviruses have been described in humans, but it remains to be established whether all of these are genuine human polyomaviruses. The most recent polyomavirus to be detected in a person is Quebec polyomavirus (QPyV), which was identified in a metagenomic analysis of a stool sample from an 85-year-old hospitalized man. We used PCR ...
  • High expression of microRNA‑126 relates to favorable prognosis for colon cancer patients 

    Selven, Hallgeir; Rasmussen Busund, Lill-Tove; Bremnes, Roy M.; Andersen, Sigve; Kilvær, Thomas Karsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-05)
    miR-126 has been identified both as a tumor suppressor and an oncogene in different types of cancer. The aim of this study was to investigate the prognostic impact of miR-126-expression in colon cancer patients. Tumor tissue from 452 patients operated for stage I–III colon cancer was retrospectively collected and tissue microarrays were constructed. miR-126 expression was evaluated by in situ ...
  • Compensation claims in pediatric orthopedics in Norway between 2012 and 2018: a nationwide study of 487 patients 

    Horn, Joachim; Rasmussen, Hanne; Bukholm, Ida Rashida Khan; Røise, Olav; Terjesen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-04)
    Background and purpose — In Norway all compensation claims based on healthcare services are handled by a government agency (NPE, Norsk Pasientskade Erstatning). We provide an epidemiological overview of claims within pediatric orthopedics in Norway, and identify the most common reasons for claims and compensations.<p> <p>Patients and methods — All compensation claims handled by NPE from 2012 to ...
  • Synthesis and biological evaluation of a novel 18F-labeled radiotracer for PET imaging of the adenosine A2A receptor 

    Lai, Thu Hang; Toussaint, Magali; Teodoro, Rodrigo; Dukić-Stefanović, Sladjana; Kranz, Mathias; Deuther-Conrad, Winnie; Moldovan, Rareş-Petru; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-25)
    The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) has emerged as a potential non-dopaminergic target for the treatment of Parkinson’s disease and, thus, the non-invasive imaging with positron emission tomography (PET) is of utmost importance to monitor the receptor expression and occupancy during an A<sub>2A</sub>R-tailored therapy. Aiming at the development of a PET radiotracer, we herein ...
  • Rehabilitation Needs, Service Provision, and Costs in the First Year Following Traumatic Injuries: Protocol for a Prospective Cohort Study 

    Søberg, Helene Lundgaard; Moksnes, Håkon Øgreid; Anke, Audny; Røise, Olav; Røe, Ellen-Cecilie Treu; Aas, Eline; Sveen, Unni; Gaarder, Christine; Næss, Pål Aksel; Helseth, Eirik; Dahl, Hilde Margrete; Becker, Frank; Løvstad, Marianne; Bartnes, Kristian; Schäfer, Christoph; Rasmussen, Mari Storli; Perrin, Paul B.; Lu, Juan; Hellstrøm, Torgeir; Hadzic-Andelic, Nada (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-14)
    Background: Traumatic injuries, defined as physical injuries with sudden onset, are a major public health problem worldwide. There is a paucity of knowledge regarding rehabilitation needs and service provision for patients with moderate and major trauma, even if rehabilitation research on a spectrum of specific injuries is available.<p> <p>Objective: This study aims to describe the prevalence of ...
  • Incidence, pattern and mechanisms of injuries and fractures in children under two years of age 

    Rosendahl, Karen; Myklebust, Ramona; Ulriksen, Kjersti Foros; Nøttveit, Andreas; Eide, Pernille; Djuve, Åsmund; Brudvik, Christina Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-18)
    Background - Fractures in children under 2 years of age are rare, and little has been published on their mechanisms. We aimed at examining the incidence, mechanisms, pattern and fracture characteristics in a large, population-based cohort of otherwise healthy children.<p> <p>Methods - This retrospective, cross-sectional study includes all children aged 0–2 years, attending the Accident and Emergency ...
  • In vivo perforasome perfusion in hemi-DIEP flaps evaluated with indocyanine-green fluorescence angiography and infrared thermography 

    Chaudhry, Muiz Akram; Mercer, James; de Weerd, Louis (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05)
    Background: There are no in vivo studies that evaluate the effect of perforator dissection on the perfusion territory of a perforator (perforasome). In this study, indocyanine green fluorescence angiography (ICG-FA) and infrared thermography (IRT) were used intraoperatively to evaluate perforasome perfusion in hemi-DIEP flaps.<p> <p>Methods: Patients selected for DIEP breast reconstruction were ...

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