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dc.contributor.authorBerdal, Margrete
dc.contributor.authorJenssen, Trond Geir
dc.date.accessioned2014-08-15T08:41:01Z
dc.date.available2014-08-15T08:41:01Z
dc.date.issued2014
dc.description.abstractAdvanced glycation end products (AGEs) react non-enzymatically with tissue proteins to form irreversible structures involved in atherosclerosis, nephropathy, retinopathy, neuropathy, and wound healing. Studies on AGE-inhibitors have demonstrated possible prevention of diabetes complications. The present open label study was conducted on aminoguanidine (AGu), an inhibitor of AGE-formation, to examine potential effects on wound healing in diabetes type 2-like db/db mice during 5 - 6 weeks. The animals were divided into 4 groups: AGu from the day of wounding (day 0) topically and/or systemically in drinking water (1 g/L; group 1, n = 13); AGu 1 g/L in drinking water from 7 weeks prior to day 0 (group 2, n = 21); AGu 5 g/L in drinking water from 9 - 11 weeks prior to day 0 (group 3, n = 6); placebo controls (group 4, n = 8). Results: Glycated hemoglobin (A1C) was significantly lower in group 3 compared to the other groups (P < 0.05). Percentage change in A1C and body weight from baseline to the end of the experiment were both related to the AGu doses (1 or 5 g/L; A1C-change, P = 0.01; weight-change, P = 0.04, both for linear trend across groups 4, 2, and 3, respectively). Even so, percentage wound closure was not improved in the AGu-treated groups compared to controls (P ≥ 0.8).en
dc.identifier.citationJournal of Diabetes Mellitus 4(2014) s. 107-114en
dc.identifier.cristinIDFRIDAID 1140961
dc.identifier.doihttp://dx.doi.org/10.4236/jdm.2014.42017
dc.identifier.issn2160-5831
dc.identifier.urihttps://hdl.handle.net/10037/6526
dc.identifier.urnURN:NBN:no-uit_munin_6133
dc.language.isoengen
dc.publisherScientific Research Publishingen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Physiopathology: 721en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Patofysiologi: 721en
dc.titleEffects of AGE inhibition with aminoguanidine in a diabetic db/db mouse wound modelen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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