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Impaired Balance Predicts Cardiovascular Disease in 70-Year-Old Individuals-An Observational Study From the Healthy Aging Initiative
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-18)Background - Limited research has explored balance problems as a prospective risk factor for cardiovascular disease (CVD). This study aimed to characterize the association between balance measures and the risk of incident CVD in a population of 70‐year‐olds.<p> <p>Methods and Results - From 2012 to 2022 a cohort of 4927 older individuals who were CVD free underwent balance assessments using a ... -
Elucidating the power of arginine restriction: taming type I interferon response in breast cancer via selective autophagy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-18)Background - Type I interferons (IFN-I) are potent alarm factors that initiate cancer cell elimination within tumors by the immune system. This critical immune response is often suppressed in aggressive tumors, thereby facilitating cancer immune escape and unfavorable patient outcome. The mechanisms underpinning IFN-I suppression in tumors are incompletely understood. Arginase-1 (ARG1)-expressing ... -
Linking metabolism and histone acetylation dynamics by integrated metabolic flux analysis of Acetyl-CoA and histone acetylation sites
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-19)Objectives - Histone acetylation is an important epigenetic modification that regulates various biological processes and cell homeostasis. Acetyl-CoA, a hub molecule of metabolism, is the substrate for histone acetylation, thus linking metabolism with epigenetic regulation. However, still relatively little is known about the dynamics of histone acetylation and its dependence on metabolic processes, ... -
Instruction-guided deidentification with synthetic test cases for Norwegian clinical text
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024)Deidentification methods, which remove directly identifying information, can be useful tools to mitigate the privacy risks associated with sharing healthcare data. However, benchmarks to evaluate deidentification methods are themselves often derived from real clinical data, making them sensitive themselves and therefore harder to share and apply. Given the rapid advances in generative language ... -
A systematic survey of 200 systematic reviews with network meta-analysis (published 2020-2021) reveals that few reviews report structured evidence summaries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-26)Objectives - To map whether and how systematic reviews (SRs) with network meta-analysis (NMA) use presentation formats to report (a) structured evidence summaries – here defined as reporting of effects estimates in absolute effects with certainty ratings and with a method to rate interventions across one or more outcome(s) – and (b) NMA results in general.<p> <p>Study Design and Setting - We ... -
The long non-coding RPPH1 is decreased in leukocytes and increased in plasma from women developing pre-eclampsia†
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-30)Previous studies show differentially expressed long non-coding RNA present in the placenta from women with pre-eclampsia, potentially playing a vital role in the pathogenesis of the complication. In a published microarray study, Ribonuclease P RNA component H1 was decreased in leukocytes from women that later developed pre-eclampsia. We hypothesized that Ribonuclease P RNA component H1 decreased ... -
Summer and polar night diets of polar cod Boreogadus saida and Atlantic cod Gadus morhua in Kongsfjorden, Svalbard, Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-17)Rapid Atlantification of marine ecosystems in the Svalbard Archipelago (Norway) is posing a threat to the local polar cod (Boreogadus saida) population. In Kongsfjorden, the decreasing population of polar cod is experiencing a shift in their prey community from Arctic to Atlantic zooplankton and fish. Simultaneously, the abundance of Atlantic cod Gadus morhua is increasing. In this study, we explore ... -
Family health care needs in a paediatric population 6 months after moderate and severe physical trauma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-29)Background: Traumatic injury is a leading cause of death and disability in children and young adults. There is a lack of evidence-based literature and guidelines on supporting families after severe child injury. This study aimed to assess the family needs and factors associated with those needs. Methods: A prospective multicenter follow-up study conducted at two Norwegian trauma centers involving ... -
The Sámi Pathfinders: Addressing the Knowledge Gap in Norwegian Mainstream Education
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-02)For at least two decades, lack of knowledge about the Sámi in Norway has been recognised as a reason for the perpetuation of stereotypes and discriminatory acts and hate speech towards them. Education about the Sámi, their lifeways, culture and rights is posited as a means of closing this gap, with the intention of influencing the majority Norwegian society’s attitudes towards the Sámi. The ... -
A new species of Lysinoe (Gastropoda: Helicoidea) from the Oligocene of Mexico
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-27)In her 1945 study on the Tertiary fossil mollusks of northeastern Mexico, Gardner listed only 2 taxa of land snails: Holospira eva Gardner, 1945 and “Helix” sp. The latter is recognized here as a new species of Lysinoe Adams & Adams, 1855 (Helicoidea, Xanthonychidae). The new species can be diagnosed from its congeners by its flattened shell profile, a lower body whorl with a faint angulation on ... -
The Relative Prevalence of Wave Packets and Coherent Structures in the Inertial and Kinetic Ranges of Turbulence as Seen by Solar Orbiter
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-16)The Solar Orbiter (SO) mission provides the opportunity to study the evolution of solar wind turbulence. We use SO observations of nine extended intervals of homogeneous turbulence to determine when turbulent magnetic field fluctuations may be characterized as: (i) wave packets and (ii) coherent structures (CSs). We perform the first systematic scale-by-scale decomposition of the magnetic field ... -
“Without IPS I Think I Would Really Fall Apart”: Individual Placement and Support as Experienced by People With Mental Illness—Phenomenological Peer Research Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-21)Having a job is an important component of recovery from mental illness and a source of economic, social, and health benefits. Most people experiencing severe mental illness (SMI) want to work but are excluded from employment opportunities. Employment specialists (ESs) working in individual placement and support (IPS) teams help persons struggling with SMI obtain competitive employment. This study ... -
Outpatient parenteral antimicrobial therapy (OPAT) using a continuous ambulatory delivery device (CADD) allowing treatment with multiple daily doses: a brief report of a Norwegian experience
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-14)Background: Outpatient parenteral antimicrobial therapy (OPAT) is safe, effective and increasingly available. While OPAT in Norwegian healthcare has been rare, a new continuous ambulatory delivery device (CADD) allowing multiple daily dosing treatments has been innovated making OPAT more accessible.<p> <p>Objectives: To describe the clinical outcome and safety using CADD in an OPAT setting. <p>Methods: ... -
3-D Visualization of Atlantic salmon skin through Ultrasound and Photoacoustic Microscopy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-22)Significance Three-dimensional photoacoustic imaging (PAM) has emerged as a promising technique for non-invasive label-free visualization and characterization of biological tissues with high spatial resolution and functional contrast.<p> <p>Aim The application of PAM and ultrasound as a microscopy technique of study for Atlantic salmon skin is presented here. <p>Approach A custom ultrasound and ... -
Incidence angle dependency and seasonal evolution of L and C-band SAR backscatter over landfast sea ice
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-02)We estimate sea-ice type specific incidence angle (IA) dependencies for dual polarized (HH/HV) L and C-band synthetic aperture radar (SAR) for the winter, melt onset and advanced melt seasons for level and deformed ice, using time-series of Advanced Land Observing Satellite-2 (ALOS-2) and Sentinel-1 imagery off the north-east coast of Greenland. The IA dependencies are used to radiometrically ... -
Relative fluid stretching and rotation for sparse trajectory observations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-03)As most mathematically justifiable Lagrangian coherent structure detection methods rely on spatial derivatives, their applicability to sparse trajectory data has been limited. For experimental fluid dynamicists and natural scientists working with Lagrangian trajectory data via passive tracers in unsteady flows (e.g. Lagrangian particle tracking or ocean buoys), obtaining material measures of ... -
Proposed categories for reporting of service organization in rehabilitation in clinical trials: a discussion paper
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-07)BACKGROUND: The lack of standardized reporting for crucial organizational factors in rehabilitation poses a significant barrier to understanding their impact on patient outcomes in clinical trials and meta-analyses. AIM: Based on the categories in the International Classification of Service Organization in Rehabilitation (ICSO-R 2.0), we aimed to develop reporting standards specifically for ... -
Artificial Intelligence-Driven Innovations in Hydrogen Safety
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-06-08)This review explores recent advancements in hydrogen gas (H2) safety through the lens of artificial intelligence (AI) techniques. As hydrogen gains prominence as a clean energy source, ensuring its safe handling becomes paramount. The paper critically evaluates the implementation of AI methodologies, including artificial neural networks (ANN), machine learning algorithms, computer vision (CV), and ... -
Navigating oneself through the eyes of the other – meanings of encountering ambulance clinicians while being in a suicidal process
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-02)Purpose - The suicidal process contains both observable and non-observable phases, and patients have described the process as characterized by loneliness and darkness. Ambulance clinicians encounter patients in all phases of the suicidal process but little is known on what meaning this encounter has to the patients. The aim of this study was to elucidate meanings of encountering ambulance clinicians ... -
What the textbooks don’t teach about the reality of running a digitally enabled health study: an interpretative phenomenological interview study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-24)Background Most studies do not produce their intended outcomes on time or within budget. However, it is challenging to identify the facilitators and barriers to successful study management when the “behind the scenes action” of especially digitally enabled health research studies are akin to a black box. Therefore, it is necessary to explore first-hand experience of the facilitators and barriers ...
