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dc.contributor.authorGuanglin, Cui
dc.contributor.authorQi, Haili
dc.contributor.authorGundersen, Mona Dixon
dc.contributor.authorYang, Hang
dc.contributor.authorChristiansen, Ingrid B
dc.contributor.authorSørbye, Sveinung Wergeland
dc.contributor.authorGoll, Rasmus
dc.contributor.authorFlorholmen, Jon
dc.date.accessioned2015-02-25T12:39:42Z
dc.date.available2015-10-17T05:50:04Z
dc.date.issued2014-10-17
dc.description.abstractMost sporadic colorectal cancers (CRCs) develop from preformed adenomas. Cytokines are involved in the transition from adenoma to CRC. Interleukin-33 (IL-33) is a newly discovered proinflammatory cytokine belonging to the IL-1 cytokine family and involved in the development of chronic inflammation and cancer. The aim of this study was to evaluate the dynamics of the IL-33/ST2 axis during the sequence of progression from normal colorectum to adenoma to carcinoma and to investigate the association of IL-33 and ST2 expression with clinicopathological parameters and prognosis. The results demonstrated that the levels of IL-33 and ST2 in adenomas (n = 50), determined by real-time PCR, were significantly higher than those of normal controls (n = 30); the levels of both IL-33/ST mRNA in CRCs (n = 50) were higher than in normal controls but lower than in adenomas. Further analysis revealed that the expression level of ST2 in CRCs was associated with tumor/node/metastasis (TNM) stage. The log-rank test showed that neither the IL-33 nor the ST2 expression level was correlated with overall survival in patients with CRC. The increased expression of IL-33/ST2 in adenomas and CRC tissues was confirmed by immunohistochemistry and was observed in both the tumor stromal cells and adenomatous/cancerous cells. Notably, increased densities of IL-33-positive and ST2-positive microvessels were found in the stroma of adenomas and CRCs. In conclusion, increased expression of the IL-33/ST2 axis along the colorectal adenoma–carcinoma sequence might be involved in the neoplastic transformation via the participation of this axis in the regulation of angiogenesis.en_US
dc.identifier.citationCancer Immunology and Immunotherapy, February 2015, Volume 64, Issue 2, pp 181–190en_US
dc.identifier.cristinIDFRIDAID 1184860
dc.identifier.doi10.1007/s00262-014-1624-x
dc.identifier.issn0340-7004
dc.identifier.urihttps://hdl.handle.net/10037/7217
dc.identifier.urnURN:NBN:no-uit_munin_6831
dc.language.isoengen_US
dc.publisherSpringer Verlagen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical immunology: 716en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectAdenoma-carcinoma transitionen
dc.subjectColorectal canceren
dc.subjectInterleukin-33en
dc.subjectST2
dc.titleDynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal canceren_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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