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dc.contributor.authorPalac, Zora
dc.contributor.authorEngesland, André
dc.contributor.authorFlaten, Gøril Eide
dc.contributor.authorSkalko-Basnet, Natasa
dc.contributor.authorFilipovic-Grcic, Jelena
dc.contributor.authorVanic, Zeljka
dc.date.accessioned2015-02-26T10:39:43Z
dc.date.available2015-03-19T06:50:05Z
dc.date.issued2014-03-19
dc.description.abstractPenetration potential of vesicles destined for trans(dermal) administration remains to be of great interests both in respect to drug therapy and cosmetic treatment. This study investigated the applicability of the phospholipid vesicle-based permeation assay (PVPA) as a novel in vitro skin barrier model for screening purposes in preformulation studies. Various classes of liposomes containing hydrophilic model drug were examined, including conventional liposomes (CLs), deformable liposomes (DLs) and propylene glycol liposomes (PGLs). The size, surface charge, membrane deformability and entrapment efficiency were found to be affected by the vesicle lipid concentration, the presence of the surfactant and propylene glycol. All liposomes exhibited prolonged drug release profiles with an initial burst effect followed by a slower release phase. The permeation of the drug from all of the tested liposomes, as assessed with the mimicked stratum corneum – PVPA model, was significantly enhanced as compared to the permeability of the drug in solution form. Although the DLs and the PGLs exhibited almost the same membrane elasticity, the permeability of the drug delivered by PGLs was higher (6.2 x 10^-6 cm/s) than DLs (5.5 x 10^-6 cm/s). Therefore, this study confirmed both the potential of liposomes as vesicles in trans(dermal) delivery and potential of the newly developed skin- PVPA for the screening and optimization of liposomes at the early preformulation stage.en_US
dc.identifier.citationJournal of liposome research 24(2014) nr. 4 s. 313-322en_US
dc.identifier.cristinIDFRIDAID 1123554
dc.identifier.doi10.3109/08982104.2014.899368
dc.identifier.issn0898-2104
dc.identifier.urihttps://hdl.handle.net/10037/7244
dc.identifier.urnURN:NBN:no-uit_munin_6836
dc.language.isoengen_US
dc.publisherInforma Healthcareen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Klinisk farmakologi: 739en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Clinical pharmacology: 739en_US
dc.titleLiposomes for (trans)dermal drug delivery: the skin-PVPA as a novel in vitro stratum corneum model in formulation developmenten_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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