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dc.contributor.authorColzi, Ilaria
dc.contributor.authorTroyan, Anna N.
dc.contributor.authorPerito, Brunella
dc.contributor.authorCasalone, Enrico
dc.contributor.authorRomoli, Riccardo
dc.contributor.authorPieraccini, Giuseppe
dc.contributor.authorSkalko-Basnet, Natasa
dc.contributor.authorAdessi, Alessandra
dc.contributor.authorRossi, Federico
dc.contributor.authorGonnelli, Cristina
dc.contributor.authorRistori, Sandra
dc.date.accessioned2015-10-01T09:07:34Z
dc.date.available2017-06-25T05:50:04Z
dc.date.issued2015-06-25
dc.description.abstractTo date the effectiveness of antibiotics is undermined by microbial resistance, threatening public health worldwide. Enhancing the efficacy of the current antibiotic arsenal is an alternative strategy. The administration of antimicrobials encapsulated in nanocarriers, such as liposomes, is considered a viable option, though with some drawbacks related to limited affinity between conventional liposomes and bacterial membranes. Here we propose a novel ‘‘top-down’’ procedure to prepare unconventional liposomes from the membranes of prokaryotes (PD-liposomes). These vectors, being obtained from bacteria with limited growth requirements, also represent low-cost systems for scalable biotechnology production. In depth physico-chemical characterization, carried out with dynamic light scattering (DLS) and Small Angle X-ray Scattering (SAXS), indicated that PD-liposomes can be suitable for the employment as antibiotic vectors. Specifically, DLS showed that the mean diameter of loaded liposomes was 200–300 nm, while SAXS showed that the structure was similar to conventional liposomes, thus allowing a direct comparison with more standard liposomal formulations. Compared to free penicillin G, PD-liposomes loaded with penicillin G showed minimal inhibitory concentrations against E. coli that were up to 16-times lower. Noteworthy, the extent of the bacterial growth inhibition was found to depend on the microorganisms from which liposomes were derived.en_US
dc.descriptionAccess to publishers version: http://dx.doi.org/10.1016/j.ejpb.2015.06.013en_US
dc.identifier.citationEuropean journal of pharmaceutics and biopharmaceutics 94(2015) s. 411-418en_US
dc.identifier.cristinIDFRIDAID 1253611
dc.identifier.doi10.1016/j.ejpb.2015.06.013
dc.identifier.issn0939-6411
dc.identifier.urihttps://hdl.handle.net/10037/8164
dc.identifier.urnURN:NBN:no-uit_munin_7753
dc.language.isoengen_US
dc.rights.accessRightsopenAccess
dc.subjectAntibiotic deliveryen_US
dc.subjectLiposomesen_US
dc.subjectBiolipidsen_US
dc.subjectAntimicrobial activityen_US
dc.subjectPenicillin resistanceen_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en_US
dc.titleAntibiotic delivery by liposomes from prokaryotic microorganisms: Similia cum similis works betteren_US
dc.typeJournal articleen_US
dc.typePreprinten_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US
dc.typeManuskripten_US


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