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dc.contributor.advisorFenton, Kristin
dc.contributor.authorPalojärvi, Ole Martin
dc.date.accessioned2015-12-16T10:43:09Z
dc.date.available2015-12-16T10:43:09Z
dc.date.issued2015-05-22
dc.description.abstractTertiary lymphoid structures are accumulation of lymphocytic cells that may occur in many organs. These structures bear a resemblance to spleen and lymph nodes which are so called secondary lymphoid organs. The formation of such structures can aggravate diseases. These structures have been shown to occur in the kidney when anti-dsDNA antibodies are produced. The development of TLS seems to occur early in the disease before the development of lupus nephritis. In this study the expression of IL7 and IL7R in the kidney of (NZBxNZW) F1 mice and expression in spleen and LNs were examined using different methods like ELISA, immunoblotting and gene expression analysis. The results show that there is some difference in expression between the organs and the different age groups of the mice.en_US
dc.identifier.urihttps://hdl.handle.net/10037/8298
dc.identifier.urnURN:NBN:no-uit_munin_7883
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.rights.accessRightsopenAccess
dc.rights.holderCopyright 2015 The Author(s)
dc.subject.courseIDFAR-3901en_US
dc.subjectMedisinsk biologien_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Other health science disciplines: 829en_US
dc.subjectFarmasien_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Andre helsefag: 829en_US
dc.titleFormation of kidney specific tertiary lymphoid structures during the initiation of anti-dsDNA antibodies and development of lupus nephritis-the role of IL-7 and IL-7Ren_US
dc.typeMaster thesisen_US
dc.typeMastergradsoppgaveen_US


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