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dc.contributor.authorHeesen, Christoph
dc.contributor.authorKasper, Jürgen
dc.contributor.authorFischer, Korbinan
dc.contributor.authorKöpke, Sascha
dc.contributor.authorRahn, Anne
dc.contributor.authorBackhus, Imke
dc.contributor.authorPoettgen, Jana
dc.contributor.authorVahter, Liina
dc.contributor.authorDrulović, Jelena S.
dc.contributor.authorVan Nunen, An
dc.contributor.authorBeckmann, Yeşim Yetimalar
dc.contributor.authorLiethmann, Katrin
dc.contributor.authorFulcher, Gary
dc.contributor.authorSolari, Alessandra
dc.date.accessioned2016-03-03T10:21:33Z
dc.date.available2016-03-03T10:21:33Z
dc.date.issued2015-10-02
dc.description.abstractBackground Adequate risk knowledge of patients is a prerequisite for shared decision making but few attempts have been made to develop assessment tools. Multiple Sclerosis (MS) is a chronic inflammatory disease of young adults with an increasing number of partially effective immunotherapies and therefore a paradigmatic disease to study patient involvement. <p>Objective/methods Based on an item bank of MS risk knowledge items and patient feedback including perceived relevance we developed a risk knowledge questionnaire for relapsing remitting (RR) MS (RIKNO 1.0) which was a primary outcome measure in a patient education trial (192 early RRMS patients). <p>Results Fourteen of the RIKNO 1.0 multiple-choice items were selected based on patient perceived relevance and item difficulty indices, and five on expert opinion. Mean item difficulty was 0.58, ranging from 0.14 to 0.79. Mean RIKNO 1.0 score increased after the educational intervention from 10.6 to 12.4 (p = 0.0003). Selected items were particularly difficult (e.g. those on absolute risk reductions of having a second relapse) and were answered correctly in only 30% of the patients, even after the intervention. <p>Conclusion Despite its high difficulty, RIKNO 1.0 is a responsive instrument to assess risk knowledge in RRMS patients participating in educational interventions.en_US
dc.identifier.citationPLoS ONE 2015, 10:e0138364(10)en_US
dc.identifier.issn1932-6203
dc.identifier.otherFRIDAID 1332063
dc.identifier.other10.1371/journal.pone.0138364
dc.identifier.urihttp://hdl.handle.net/10037/8629
dc.identifier.urnURN:NBN:no-uit_munin_8255
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752en_US
dc.titleRisk knowledge in relapsing multiple sclerosis (RIKNO 1.0) - Development of an outcome instrument for educational interventionsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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