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Stereotactic radiation therapy for liver metastases: Factors affecting local control and survival

Permanent link
https://hdl.handle.net/10037/8710
DOI
https://doi.org/10.1186/s13014-015-0369-9
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Date
2015-03-20
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Andratschke, Nicolaus H.J.; Nieder, Carsten; Heppt, Franz; Molls, Michael; Zimmermann, Frank
Abstract
Purpose: To report on outcome and toxicity of stereotactic body radiotherapy (SBRT) for liver metastases in patients not eligible for surgery.

Methods: From 2000 to 2009, 74 patients with 91 liver metastases from different primaries have been treated with SBRT at our institution. Median planning target volume was 123 ccm (range: 10.6-1074 ccm). Treatment consisted of 3–5 fractions with 5–12.5 Gy/ fraction prescribed to the surrounding 60-95% isodose with daily image guidance. Regular follow-up included CT or MRI imaging until tumor progression.

Results: Median local recurrence-free interval was 23 months with a local control rate of 74.7%, 48.3% and 48.3% after 1, 2 and 3 years. Only minimum biologically effective dose (BED) to gross tumor volume (GTV) remained as independent significant factor for local control in multivariate analysis. No local recurrences were observed in lesions (n = 12) which received a minimal BED to the GTV of 120 Gy. Including 26 local recurrences, 67 patients (91%) showed disease progression after SBRT with a median time of 5 months. Median overall survival was 27 months with survival rates of 77%, 30% and 27% at 1, 3 and 5 years. On multivariate analysis only GTV volume remained as independent significant prognostic factor for overall survival (p = 0.002). No grade 3 to 5 acute toxicity and no grade 4 or 5 late toxicity occurred.

Conclusion: SBRT for liver metastases was well tolerated in this non-selected patient cohort and yielded good local control despite the considerable size of most lesions treated. Long-term survival is possible after SBRT.

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License: Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
Publisher
BioMed Central
Citation
Radiation Oncology 2015, 10:69
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