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dc.contributor.authorFretland, Åsmund Avdem
dc.contributor.authorSokolov, Andrey
dc.contributor.authorPostriganova, Nadezda
dc.contributor.authorKazaryan, Airazat M.
dc.contributor.authorPischke, Søren Erik
dc.contributor.authorNilsson, Per
dc.contributor.authorRognes, Ingrid Nygren
dc.contributor.authorBjørnbeth, Bjørn Atle
dc.contributor.authorFagerland, Morten
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorEdwin, Bjørn
dc.date.accessioned2016-03-09T12:55:39Z
dc.date.available2016-03-09T12:55:39Z
dc.date.issued2015-10
dc.description.abstractLaparoscopic and open liver resection have not been compared in randomized trials. The aim of the current study was to compare the inflammatory response after laparoscopic and open resection of colorectal liver metastases (CLM) in a randomized controlled trial. This was a predefined exploratory substudy within the Oslo CoMetstudy. Forty-five patients with CLM were randomized to laparoscopic (n ¼ 23) or open (n ¼ 22) resection. Ethylenediaminetetraacetic acidplasma samples were collected preoperatively and at defined time points during and after surgery and snap frozen at 80 o C. A total of 25 markers were examined using luminex and enzyme-linked immunosorbent assay techniques: high-mobility box group 1(HMGB-1), cellfree DNA (cfDNA), cytokines, and terminal C5b-9 complement complex complement activation. Eight inflammatory markers increased significantly from baseline: HMGB-1, cfDNA, interleukin (IL)-6, C-reactive protein, macrophage inflammatory protein -1b, monocyte chemotactic protein -1, IL-10, and terminal C5b-9 complement complex. Peak levels were reached at the end of or shortly after surgery. Five markers, HMGB-1, cfDNA, IL-6, Creactive protein, and macrophage inflammatory protein -1b, showed significantly higher levels in the open surgery group compared with the laparoscopic surgery group.en_US
dc.descriptionLicence: Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)en_US
dc.identifier.citationMedicine (Baltimore, Md.) 2015, 94:e1786(42)en_US
dc.identifier.issn0025-7974
dc.identifier.otherFRIDAID 1318410
dc.identifier.other10.1097/MD.0000000000001786
dc.identifier.urihttp://hdl.handle.net/10037/8807
dc.identifier.urnURN:NBN:no-uit_munin_8381
dc.language.isoengen_US
dc.publisherLippincott, Williams & Wilkins: Open Access Journalsen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.titleInflammatory response after laparoscopic versus open resection of colorectal liver metastases: Data from the oslo-comet trialen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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