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dc.contributor.authorIversen, Trond
dc.contributor.authorSolberg, Tore
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorWaterloo, Knut
dc.contributor.authorBrox, Jens Ivar
dc.contributor.authorIngebrigtsen, Tor
dc.date.accessioned2016-03-10T11:27:39Z
dc.date.available2016-03-10T11:27:39Z
dc.date.issued2015-02-07
dc.description.abstractBackground: Identification of prognostic factors for persistent pain and disability are important for better understanding of the clinical course of chronic unilateral lumbar radiculopathy and to assist clinical decision-making. There is a lack of scientific evidence concerning prognostic factors. The aim of this study was to identify clinically relevant predictors for outcome at 52 weeks. <p>Methods: 116 patients were included in a sham controlled clinical trial on epidural injection of glucocorticoids in patients with chronic unilateral lumbar radiculopathy. Success at follow-up was ≤17.5 for visual analogue scale (VAS) leg pain, ≤22.5 for VAS back pain and ≤20 for Oswestry Disability Index (ODI). Fifteen clinically relevant variables included demographic, psychosocial, clinical and radiological data and were analysed using a logistic multivariable regression analysis. <p>Results: At follow-up, 75 (64.7%) patients had reached a successful outcome with an ODI score ≤20, 54 (46.6%) with a VAS leg pain score ≤17.5, and 47 (40.5%) with a VAS back pain score ≤22.5. Lower age (OR 0.94 (CI 0.89–0.99) for each year decrease in age) and FABQ Work ≥34 (OR 0.16 (CI 0.04-0.61)) were independent variables predicting a successful outcome on the ODI. Higher education (OR 5.77 (CI 1.46–22.87)) and working full-time (OR 2.70 (CI 1.02–7.18)) were statistically significant (P <0.05) independent predictors for successful outcome (VAS score ≤17.5) on the measure of leg pain. Lower age predicted success on ODI (OR 0.94 (95% CI 0.89 to 0.99) for each year) and less back pain (OR 0.94 (0.90 to 0.99)), while higher education (OR 5.77 (1.46 to 22.87)), working full-time (OR 2.70 (1.02 to 7.18)) and muscle weakness at baseline (OR 4.11 (1.24 to 13.61) predicted less leg pain, and reflex impairment at baseline predicted the contrary (OR 0.39 (0.15 to 0.97)). <p>Conclusions: Lower age, higher education, working full-time and low fear avoidance beliefs each predict a better outcome of chronic unilateral lumbar radiculopathy. Specifically, lower age and low fear avoidance predict a better functional outcome and less back pain, while higher education and working full-time predict less leg pain. These results should be validated in further studies before being used to inform patients. <p>Trial registration: Current Controlled Trials ISRCTN12574253. Registered 18 May 2005.en_US
dc.descriptionPublished version, also available at <a href=http://dx.doi.org/10.1186/s12891-015-0474-9>http://dx.doi.org/10.1186/s12891-015-0474-9</a>en_US
dc.identifier.citationBMC Musculoskeletal Disorders (2015) 16:17en_US
dc.identifier.cristinIDFRIDAID 1252627
dc.identifier.doi10.1186/s12891-015-0474-9
dc.identifier.issn1471-2474
dc.identifier.urihttps://hdl.handle.net/10037/8845
dc.identifier.urnURN:NBN:no-uit_munin_8419
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Fysikalsk medisin og rehabilitering: 764en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Physical medicine and rehabilitation: 764en_US
dc.subjectChronic unilateral lumbar radiculopathyen_US
dc.subjectLumbar nerve root impingementen_US
dc.subjectOutcome predictionen_US
dc.subjectRadiculopathyen_US
dc.subjectSciaticaen_US
dc.titleOutcome prediction in chronic unilateral lumbar radiculopathy: Prospective cohort studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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