ub.xmlui.mirage2.page-structure.muninLogoub.xmlui.mirage2.page-structure.openResearchArchiveLogo
    • EnglishEnglish
    • norsknorsk
  • Velg spraaknorsk 
    • EnglishEnglish
    • norsknorsk
  • Administrasjon/UB
Vis innførsel 
  •   Hjem
  • Det helsevitenskapelige fakultet
  • Institutt for klinisk medisin
  • Artikler, rapporter og annet (klinisk medisin)
  • Vis innførsel
  •   Hjem
  • Det helsevitenskapelige fakultet
  • Institutt for klinisk medisin
  • Artikler, rapporter og annet (klinisk medisin)
  • Vis innførsel
JavaScript is disabled for your browser. Some features of this site may not work without it.

Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study

Permanent lenke
https://hdl.handle.net/10037/8954
DOI
https://doi.org/10.1053/j.ajkd.2015.10.025
Thumbnail
Åpne
article.pdf (440.6Kb)
Accepted manuscript version (PDF)
Dato
2015-12-29
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Melsom, Toralf; Schei, Jørgen; Stefansson, Vidar Tor Nyborg; Solbu, Marit Dahl; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Wilsgaard, Tom; Eriksen, Bjørn Odvar
Sammendrag
Background: The role of prediabetes as a risk factor for hyperfiltration and albuminuria in persons who do not develop diabetes is unclear. The lack of evidence is mainly due to the difficulty of accurately assessing the glomerular filtration rate (GFR) in the near-normal range of GFR. We investigated whether prediabetes is an independent risk factor for glomerular hyperfiltration and high-normal urinary albumin-creatinine ratio (ACR) using measured GFR (mGFR) rather than estimated GFR.

Study Design: Prospective cohort study based on the Renal Iohexol Clearance Survey in Tromsø 6 (RENIS-T6) and the RENIS Follow-Up Study. Median observation time was 5.6 years.

Setting & Participants: A representative sample of 1,261 persons without diabetes mellitus (DM) from the general population aged 50 to 62 years.

Predictor: Prediabetes defined by fasting glucose and hemoglobin A1c according to levels suggested by the American Diabetes Association (preDMADA) and the International Expert Committee of 2009 (preDMIEC).

Outcomes: Change in mGFR; hyperfiltration defined as mGFR . 90th percentile adjusted for age, sex, weight, and height; and high-normal ACR (.10 mg/g) at follow-up.

Measurements: GFR was measured with iohexol clearance.

Results: Baseline fasting glucose, hemoglobin A1c, and both definitions of prediabetes were predictors of higher mGFR at follow-up and lower annual mGFR decline in multivariable-adjusted regression analyses. Participants with preDMIEC had an OR for hyperfiltration of 1.95 (95% CI, 1.20-3.17) and for high-normal ACR of 1.83 (95% CI, 1.04-3.22) at follow-up. We adjusted for cardiovascular risk factors including ambulatory blood pressure at baseline and change in use of antihypertensive medication between baseline and follow-up.

Limitations: Only middle-aged white patients participated. There is no consensus on how to define glomerular hyperfiltration.

Conclusions: Our findings imply an independent role of prediabetes in the development of glomerular hyperfiltration and albuminuria. Prediabetes might be a target for early treatment to prevent chronic kidney disease in chronic hyperglycemia.

Beskrivelse
© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Accepted manuscript version. Published version available at http://dx.doi.org/10.1053/j.ajkd.2015.10.025

Forlag
Elsevier
Sitering
American Journal of Kidney Diseases 2015
Metadata
Vis full innførsel
Samlinger
  • Artikler, rapporter og annet (klinisk medisin) [1974]

Bla

Bla i hele MuninEnheter og samlingerForfatterlisteTittelDatoBla i denne samlingenForfatterlisteTittelDato
Logg inn

Statistikk

Antall visninger
UiT

Munin bygger på DSpace

UiT Norges Arktiske Universitet
Universitetsbiblioteket
uit.no/ub - munin@ub.uit.no

Tilgjengelighetserklæring