Show simple item record

dc.contributor.authorIngebrigtsen, Richard Andre
dc.contributor.authorHansen, Espen
dc.contributor.authorAndersen, Jeanette hammer
dc.contributor.authorEilertsen, Hans Christian
dc.date.accessioned2016-03-16T09:59:07Z
dc.date.available2016-03-16T09:59:07Z
dc.date.issued2015-06-05
dc.description.abstractIsolates of five pelagic North Atlantic marine diatoms (Bacillariophyceae): Attheya longicornis, Chaetoceros socialis, Chaetoceros furcellatus, Skeletonema marinoi and Porosira glacialis were cultivated in large photobioreactors at two light and two temperature regimes to test if this affected bioactivity. We screened for bioactivity in assays representing five different therapeutic areas: diabetes II (PTP1b), cancer (melanoma cells, A2058), anti-oxidants (FRAP), immunomodulation (TNFa) and anti-infection (MRSA, Enterococcus faecalis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa). All the diatom strains showed activity in two or more assays. We detected differences in bioactivity both between species and within species cultivated with different light and temperature regimes. Our results demonstrate the potential for a more exhaustive exploitation of diatom metabolites that can be obtained by manipulation of the cultivation conditions.en_US
dc.descriptionPublished version, also available at <a href=http://doi.org/10.1007/s10811-015-0631-4>http://doi.org/10.1007/s10811-015-0631-4</a>en_US
dc.identifier.citationJournal of Applied Phycology, April 2016, Volume 28, Issue 2, pp 939-950en_US
dc.identifier.cristinIDFRIDAID 1260534
dc.identifier.doi10.1007/s10811-015-0631-4
dc.identifier.issn1573-5176
dc.identifier.urihttps://hdl.handle.net/10037/8981
dc.identifier.urnURN:NBN:no-uit_munin_8550
dc.language.isoengen_US
dc.publisherSpringer Verlagen_US
dc.rights.accessRightsopenAccess
dc.subjectDiatomsen_US
dc.subjectBioactivityen_US
dc.subjectOSMAC methoden_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470en_US
dc.subjectVDP::Mathematics and natural science: 400::Basic biosciences: 470en_US
dc.titleLight and temperature effects on bioactivity in diatomsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record