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dc.contributor.advisorSkalko-Basnet, Natasa
dc.contributor.authorHadafow, Muna Abukar
dc.date.accessioned2015-03-11T06:11:49Z
dc.date.accessioned2016-05-26T07:50:16Z
dc.date.available2016-05-26T07:50:16Z
dc.date.issued2014-05-24
dc.description.abstractDue to inappropriate or excessive use of antibiotics, multi resistance has become a global problem which threatens the public health. Photodynamic therapy has emerged as a promising and important approach in many fields of drug therapy. In recent years, many studies on photodynamic therapy for infections have shown promising results. One of the advantages of using PDT in treatment of infections is the mechanism of drug action which differs from that of antibiotics. This opens the door for the possibilities of treating multidrug resistant bacteria. PDT requires photosensitizer (PS), which are stable, nontoxic and effective. To improve the delivery of PS usually a delivery system which provides better stability and control of the PS. Polymer-based nanoparticles have been proposed as a suitable delivery system based on their advantages (e.g. biodegradable, less toxicity, microbial and hemostatic properties). A New Chemical Entity (NCE) recently developed and patented by Photocure ASA is expected to exhibit superior antimicrobial properties and improved wound healing. Chitosan lecithin nanoparticles were selected and developed as a carrier system for this new entity. At this stage of development, the delivery system was found to have many stability issues which need to be optimized in the future. The sizes of the carrier were found to be suitable but their entrapment efficiency was found to be rather low (less than 22 %).en_US
dc.identifier.urihttps://hdl.handle.net/10037/9238
dc.identifier.urnURN:NBN:no-uit_munin_8799
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.rights.accessRightsopenAccess
dc.rights.holderCopyright 2014 The Author(s)
dc.subject.courseIDFAR-3901en_US
dc.subjectVDP::Teknologi: 500::Kjemisk teknologi: 560::Farmasøytisk formulering og teknologi: 568en_US
dc.subjectVDP::Technology: 500::Chemical engineering: 560::Pharmaceutical formulation and technology: 568en_US
dc.titleChitosan-based drug delivery system for a new chemical entity for photodynamic wound therapyen_US
dc.typeMaster thesisen_US
dc.typeMastergradsoppgaveen_US


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