English
norskBlar i forfatter "Solbu, Marit Dahl"
Viser treff 21-36 av 36
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Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-14)<p><i>Background - </i>Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain and kidneys have low-impedance vascular beds, rendering them susceptible to damage from pulsatile blood flow. An association between mildly reduced GFR and cognitive ... -
Low-grade impairments in cognitive and kidney function in a healthy middle-aged general population: a cross-sectional study
(Master thesis; Mastergradsoppgave, 2019-10-28)Background: Although the relationship between manifest chronic kidney disease and reduced cognitive function is well established, limited data exists on GFR and cognitive function in the general population. Both the brain and kidneys have low-impedance vascular beds, rendering them susceptible to damage from pulsatile blood flow. An association between mildly reduced GFR and cognitive function in ... -
Mild Albuminuria Is a Risk Factor for Faster GFR Decline in the Nondiabetic Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-08)<i>Introduction</i>: A minimal increase in the albumin-to-creatinine ratio (ACR) predicts cardiovascular disease and mortality, but whether it predicts kidney function loss in nondiabetic persons is unclear. We investigated the association between ACR in the optimal or high-normal range and the rate of glomerular filtration rate (GFR) decline in a cohort from the general population without diabetes, ... -
Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-10)Background: Elevated uric acid (UA) is associated with the presence of the metabolic syndrome (MetS). In a prospective cohort study, we assessed whether baseline and longitudinal change in UA were risk factors for development of MetS and its individual components. <br> Methods: We included 3087 women and 2996 men who had UA measured in the population based Tromsø Study 1994–95. The participants ... -
Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-29) -
Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-29)Background: The role of prediabetes as a risk factor for hyperfiltration and albuminuria in persons who do not develop diabetes is unclear. The lack of evidence is mainly due to the difficulty of accurately assessing the glomerular filtration rate (GFR) in the near-normal range of GFR. We investigated whether prediabetes is an independent risk factor for glomerular hyperfiltration and high-normal ... -
Quality of life following renal sympathetic denervation in treatment-resistant hypertensive patients: a two-year follow-up study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-10)Objective. Hypertension is a significant health burden. In the last 10 years, renal sympathetic denervation has been tested as a potential treatment option for a select group of patients with treatmentresistant hypertension. The aim of this study was to broadly assess the quality of life in patients undergoing renal sympathetic denervation with two years’ follow-up. Materials and methods. Patients ... -
Serum Matrix Metalloproteinase 7 and accelerated glomerular filtration rate decline in a general non-diabetic population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-26)Background. Age-related reduction of glomerular filtration rate (GFR) is a major contributor to the global chronic kidney disease (CKD) epidemic. We investigated whether baseline serum levels of the pro-fibrotic matrix metalloproteinase 2 (MMP2), MMP7 and their inhibitor, tissue inhibitor of metalloproteinase 1 (TIMP1), which mediates fibrosis development in aging animals, were associated with ... -
Sex Differences in Age-Related Loss of Kidney Function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-30)Background - CKD is more prevalent in women, but more men receive kidney replacement therapy for kidney failure. This apparent contradiction is not well understood.<p> <p>Methods - We investigated sex differences in the loss of kidney function and whether any sex disparities could be explained by comorbidity or CKD risk factors. In the Renal Iohexol Clearance Survey (RENIS) in northern Europe, ... -
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: The role of serum uric acid as an independent predictor of cardiovascular disease and death is uncertain in the general population. Adjustments for additional cardiovascular risk factors have not been consistent. We examined the association of serum uric acid with all-cause mortality, ischemic stroke and myocardial infarction in a prospective population based study, with several traditional ... -
Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-11)Background: The role of uric acid in development of renal dysfunction (RD) remains controversial. Earlier studies have reported inconsistent results, possibly because of their varying ability to adjust for confounding. The impact of longitudinal change in uric acid on renal outcome has not been assessed previously. We aimed to study the impact of change in serum uric acid (SUA) as well as baseline ... -
Uric acid predicts mortality and ischaemic stroke in subjects with diastolic dysfunction: the Tromsø Study 1994-2013
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-31)Aims: To investigate whether serum uric acid predicts adverse outcomes in persons with indices of diastolic dysfunction in a general population. <br>Methods and results: We performed a prospective cohort study among 1460 women and 1480 men from 1994 to 2013. End- points were all-cause mortality, incident myocardial infarction, and incident ischaemic stroke. We strati fi ed the analyses ... -
Urinary excretion of epidermal growth factor and rapid loss of kidney function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-17)Background - Lower urinary excretion of the kidney tubule–specific biomarker epidermal growth factor (uEGF) is associated with increased risk of renal function [glomerular filtration rate (GFR)] loss in diabetes and in patients with established chronic kidney disease (CKD). We investigated whether uEGF is associated with rapid GFR decline or incident CKD in the general population.<p> <p>Methods ... -
Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-07)<p><i>Introduction</i>: Markers of oxidative stress increase with age and are prevalent with chronic kidney disease. However, the role of oxidative stress markers as predictors for kidney function decline in the general population is unclear.</p> <p><i>Methods</i>: We investigated whether a baseline urinary excretion of oxidative DNA damage (8-oxo-7,8-dihydro-2′-deoxyguanosine [8-oxodG]) and ... -
Urinary orosomucoid is associated with diastolic dysfunction and carotid arteriopathy in the general population. Cross-sectional data from the Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-02)Objectives. Urinary albumin excretion is a risk marker for cardiovascular disease (CVD). Studies suggest that urinary orosomucoid may be a more sensitive marker of general endothelial dysfunction than albuminuria. The aim of this population-based cross-sectional study was to examine the associations between urinary orosomucoid to creatinine ratio (UOCR), urinary albumin to creatinine ratio ... -
Validation of eGFR for Detecting Associations Between Serum Protein Biomarkers and Subsequent GFR Decline
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08)Significance Statement - eGFR from creatinine, cystatin C, or both has been primarily used in search of biomarkers for GFR decline. Whether the relationships between biomarkers and eGFR decline are similar to associations with measured GFR (mGFR) decline has not been investigated. This study revealed that some biomarkers showed statistically significant different associations with eGFR decline ...
