Blar i forfatter "Melsom, Toralf"

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    • Ambulatory blood pressure as risk factor for long-term kidney function decline in the general population: a distributional regression approach 

      Eriksen, Bjørn Odvar; Fasiolo, Matteo; Mathisen, Ulla Dorte; Jenssen, Trond; Stefansson, Vidar Tor Nyborg; Melsom, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-31)
      The results of randomized controlled trials are unclear about the long-term efect of blood pressure (BP) on kidney function assessed as the glomerular fltration rate (GFR) in persons without chronic kidney disease or diabetes. The limited duration of follow-up and use of imprecise methods for assessing BP and GFR are important reasons why this issue has not been settled. Since a long-term randomized ...

    • The Association Between Adiponectin, Serum Uric Acid and Urinary Markers of Renal Damage in the General Population: Cross-Sectional Data from the Tromsø Study 

      Solbu, Marit Dahl; Norvik, Jon Viljar; Storhaug, Hilde-Merete; Eriksen, Bjørn Odvar; Melsom, Toralf; Eggen, Anne Elise; Zykova, Svetlana; Kronborg, Jens; Jenssen, Trond Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-14)
      Background/Aims: Uric acid may cause renal damage, whereas adiponectin in some studies has been reported to have renoprotective properties. The renoprotective role of adiponectin under the influence of hyperuricemia has not been explored. We assessed the cross-sectional association between adiponectin, serum uric acid (SUA) and urinary biomarkers of glomerular and tubular damage (albumin-creatinine ...

    • The Association Between Metabolic Syndrome, Hyperfiltration, and Long-Term GFR Decline in the General Population 

      Bystad, Erikka Wikan; Stefansson, Vidar Tor Nyborg; Eriksen, Bjørn Odvar; Melsom, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-01)
      Introduction: One-quarter of adults worldwide meet the criteria of metabolic syndrome (MetS). MetS increases the risk of diabetes, chronic kidney disease (CKD), and cardiovascular disease. However, the association between MetS, hyperfiltration, and long-term glomerular filtration rate (GFR) decline in the general population is unknown.<p> <p>Methods: In the Renal Iohexol Clearance Survey (RENIS), ...

    • The Association between Urinary Sodium-Potassium Ratio, Kidney Function, and Blood Pressure in a Cohort from the General Population 

      Brobak, Karl Marius; Melsom, Toralf; Eriksen, Bjørn Odvar; Høieggen, Aud; Norvik, Jon Viljar Porserud; Solbu, Marit Dahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-21)
      Introduction: Subclinical kidney dysfunction may contribute to salt-sensitive hypertension. We assessed the association between the urinary sodium-potassium ratio (Na/K ratio) and blood pressure (BP) in a general population cohort without diabetes, chronic kidney disease, cardiovascular disease, or treated hypertension. We investigated whether any such association was mediated by the kidney function ...

    • Association of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Population 

      Melsom, Toralf; Norvik, Jon Viljar; Enoksen, Inger Therese; Stefansson, Vidar Tor Nyborg; Rismo, Renathe; Jenssen, Trond; Solbu, Marit Dahl; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-18)
      <i>Introduction</i> - Although lower high-density lipoprotein cholesterol (HDL-C) levels are considered a risk factor for cardiovascular disease (CVD), experimental evidence suggest that aging, inflammation, and oxidative stress may remodel HDL-C, leading to dysfunctional HDL-C. Population studies on HDL-C and loss of the glomerular filtration rate (GFR) reported inconsistent results, but they used ...

    • Associations of urinary orosomucoid, N-acetyl-β-D-glucosaminidase, and albumin with blood pressure and hypertension during 7 years of follow-up. The Tromsø Study 

      Brobak, Karl Marius; Andreassen, Runa Marie; Melsom, Toralf; Høieggen, Aud; Norvik, Jon Viljar; Solbu, Marit Dahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-03)
      Purpose: Subclinical chronic kidney disease is known to exacerbate hypertension and progression of kidney damage. In order to initiate timely interventions, early biomarkers for this vicious circle are needed. Our aim was to describe the cross-sectional associations of urinary orosomucoid and urinary N-acetyl-b-D-glucosaminidase (NAG) with blood pressure and the longitudinal associations of urinary ...

    • Blood pressure and age-related GFR decline in the general population 

      Eriksen, Bjørn Odvar; Stefansson, Vidar Tor Nyborg; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Schei, Jørgen; Solbu, Marit Dahl; Wilsgaard, Tom; Melsom, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-28)
      Background: <br> Hypertension is one of the most important causes of end-stage renal disease, but it is unclear whether elevated blood pressure (BP) also accelerates the gradual decline in the glomerular filtration rate (GFR) seen in the general population with increasing age. The reason may be that most studies have considered only baseline BP and not the effects of changes in BP, antihypertensive ...

    • Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study 

      Stefansson, Vidar Tor Nyborg; Schei, Jørgen; Jenssen, Trond Geir; Melsom, Toralf; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-10)
      <p><i>Background - </i>Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity is associated with hyperfiltration in the non-diabetic general population, remains unresolved due to a lack of consensus regarding the definition ...

    • Comparability of plasma iohexol clearance across population-based cohorts 

      Eriksen, Bjørn Odvar; Schaeffner, Elke; Melsom, Toralf; Ebert, Natalie; van der Giet, Markus; Gudnason, Vilmundur; Indridasson, Olafur S.; Karger, Amy B.; Levey, Andrew S.; Schuchardt, Mirjam; Sørensen, Liv Karin; Pálsson, Runólfur (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-23)
      Rationale & Objective: Glomerular filtration rate (GFR) estimation based on creatinine or cystatin C level is currently the standard method for assessing GFR in epidemiologic research and clinical trials despite several important and well-known limitations. Plasma iohexol clearance has been proposed as an inexpensive method for measuring GFR that could replace estimated GFR in many research ...

    • Comparison between the EKFC-equation and machine learning models to predict Glomerular Filtration Rate 

      Nakano, Felipe Kenji; Åkesson, Anna; de Boer, Jasper; Dedja, Klest; D’hondt, Robbe; Haredasht, Fateme Nateghi; Björk, Jonas; Courbebaisse, Marie; Couzi, Lionel; Ebert, Natalie; Eriksen, Bjørn Odvar; Dalton, R. Neil; Derain-Dubourg, Laurence; Gaillard, Francois; Garrouste, Cyril; Grubb, Anders; Jacquemont, Lola; Hansson, Magnus; Kamar, Nassim; Legendre, Christophe; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Rostaing, Lionel; Rule, Andrew D.; Schaeffner, Elke; Sundin, Per-Ola; Bökenkamp, Arend; Berg, Ulla; Åsling-Monemi, Kajsa; Selistre, Luciano; Larsson, Anders; Nyman, Ulf; Lanot, Antoine; Pottel, Hans; Delanaye, Pierre; Vens, Celine (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-02)
      In clinical practice, the glomerular filtration rate (GFR), a measurement of kidney functioning, is normally calculated using equations, such as the European Kidney Function Consortium (EKFC) equation. Despite being the most general equation, EKFC, just like previously proposed approaches, can still struggle to achieve satisfactory performance, limiting its clinical applicability. As a possible ...

    • Correlation between baseline GFR and subsequent change in GFR in Norwegian adults without diabetes and in Pima Indians 

      Melsom, Toralf; Nair, Viji; Schei, Jørgen; Mariani, Laura; Stefansson, Vidar Tor Nyborg; Harder, Jennifer L.; Jenssen, Trond Geir; Solbu, Marit Dahl; Norvik, Jon Viljar; Looker, Helen; Knowler, William C.; Kretzler, Matthias; Nelson, Robert G.; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-28)
      <p><i>Rationale & Objective - </i>An elevated glomerular filtration rate (GFR), or renal hyperfiltration, may predispose individuals to subsequent rapid GFR decline in diabetes, obesity, and metabolic syndrome. Although this hypothesis is supported by results of experimental studies, the importance of hyperfiltration at the population level remains controversial. We investigated whether higher ...

    • Cystatin C-Based Equation to Estimate GFR without the Inclusion of Race and Sex 

      Pottel, Hans; Björk, Jonas; Rule, Andrew D.; Ebert, Natalie; Eriksen, Bjørn Odvar; Dubourg, Laurence; Vidal-Petiot, Emmanuelle; Grubb, Anders; Hansson, Magnus; Lamb, Edmund J.; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Schaeffner, Elke; Sundin, Per-Ola; Åkesson, Anna; Larsson, Anders; Cavalier, Etienne; Bukabau, Justine B.; Sumaili, Ernest K.; Yayo, Eric; Monnet, Dagui; Flamant, Martin; Nyman, Ulf; Delanaye, Pierre (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-26)
      BACKGROUND - The accuracy of estimation of kidney function with the use of routine metabolic tests, such as measurement of the serum creatinine level, has been controversial. The European Kidney Function Consortium (EKFC) developed a creatinine-based equation (EKFC eGFRcr) to estimate the glomerular filtration rate (GFR) with a rescaled serum creatinine level (i.e., the serum creatinine level is ...

    • Data on the relation between renal biomarkers and measured glomerular filtration rate 

      Pottel, Hans; Dubourg, Laurence; Schaeffner, Elke; Eriksen, Bjørn Odvar; Melsom, Toralf; Lamb, Edmund J.; Rule, Andrew D.; Turner, Stephen T; Glassock, Richard J.; De Souza, Vandrea; Selistre, Luciano; Goffin, Karolien; Pauwels, Steven; Mariat, Christophe; Flamant, Martin; Bevc, Sebastjan; Delanaye, Pierre; Ebert, Natalie (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10)
      The data presented in this article are related to the research article entitled “The Diagnostic Value of Rescaled Renal Biomarkers Serum Creatinine and Serum Cystatin C and their Relation with Measured Glomerular Filtration Rate” (Pottel et al. (2017) [1]). Data are presented demonstrating the rationale for the normalization or rescaling of serum cystatin C, equivalent to the rescaling of serum ...

    • Elevated blood pressure is not associated with accelerated glomerular filtration rate decline in the general non-diabetic middle-aged population 

      Eriksen, Bjørn Odvar; Stefansson, Vidar Tor Nyborg; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Schei, Jørgen; Solbu, Marit Dahl; Wilsgaard, Tom; Melsom, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-14)
      Although hypertension is a risk factor for end-stage renal disease, this complication develops in only a minority of hypertensive patients. Whether non-malignant hypertension itself is sufficient to cause reduced glomerular filtration rate (GFR) is unclear. We investigated whether elevated blood pressure (BP) was associated with accelerated GFR decline in the general population. The study ...

    • Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population 

      Eriksen, Bjørn Odvar; Løchen, Maja-Lisa; Arntzen, Kjell Arne; Bertelsen, Geir; Eilertsen, Britt-Ann; Hanno, Therese von; Herder, Marit; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Melsom, Toralf; Njølstad, Inger; Solbu, Marit Dahl; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11)
      Background/Aims: Estimated GFR (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR ...

    • Estimated GFR is biased by non-traditional cardiovascular risk factors 

      Melsom, Toralf; Fuskevåg, Ole-Martin; Mathisen, Ulla Dorte; Strand, Harald; Schei, Jørgen; Jenssen, Trond Geir; Solbu, Marit Dahl; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-23)
      Background: Estimated glomerular filtration rate (eGFR) based on either cystatin C or creatinine perform similarly in estimating measured GFR, but associate differently with cardiovascular disease (CVD) and mortality. This could be due to confounding by non-GFRrelated traits associated with cystatin C and creatinine levels. We investigated non-GFRrelated associations between eGFR and two types ...

    • Estimated Glomerular Filtration Rate (eGFR) based on cystatin C was associated with increased risk of hip and proximal humerus fractures in women and decreased risk of hip fracture in men, whereas eGFR based on creatinine was not associated with fracture risk in both sexes: The Tromsø Study 

      Nordvåg, Sofie; Solbu, Marit Dahl; Melsom, Toralf; Nissen, Frida Igland; Andreasen, Camilla; Borgen, Tove Tveitan; Eriksen, Bjørn Odvar; Joakimsen, Ragnar Martin; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-14)
      <i>Purpose</i> - Patients with end-stage kidney disease have an increased fracture risk. Whether mild to moderate reductions in kidney function is associated with increased fracture risk is uncertain. Results from previous studies may be confounded by muscle mass because of the use of creatinine-based estimates of the glomerular filtration rate (eGFRcre). We tested the hypothesis that lower eGFR ...

    • Extending the Lund-Malmö creatinine-based GFR equation to cystatin C–validation results from the European Kidney Function Consortium (EKFC) cohort of children and adults 

      Björk, Jonas; Nyman, Ulf; Berg, Ulla; Bökenkamp, Arend; Cavalier, Etienne; Ebert, Natalie; Eriksen, Bjørn Odvar; Derain Dubourg, Laurence; Goffin, Karolien; Grubb, Anders; Hansson, Magnus; Larsson, Anders; Lemoine, Sandrine; Littmann, Karin; Mariat, Christophe; Melsom, Toralf; Schaeffner, Elke; Sundin, Per-Ola; Åsling-Monemi, Kajsa; Delanaye, Pierre; Pottel, Hans (Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-08)
      The aim of the present study was to extend the creatinine-based Lund-Malmö GFR equation for use with rescaled cystatin C (r-LMR<sub>Cys</sub>) and validate it against measured GFR (mGFR) in the EKFC cystatin C cohort of children (n = 2,293) and adults (n = 7,727). Rescaling was obtained by dividing each biomarker by a Q-value, representing the population-specific median biomarker level among healthy ...

    • GFR in healthy aging: An individual participant data meta-analysis of iohexol clearance in european population-based cohorts 

      Eriksen, Bjørn Odvar; Pálsson, Runólfur; Ebert, Natalie; Melsom, Toralf; van der Giet, Markus; Gudnason, Vilmundur; Indridasson, Olafur S.; Inker, Lesley A.; Jenssen, Trond Geir; Levey, Andrew S.; Solbu, Marit Dahl; Tighiouart, Hocine; Schaeffner, Elke (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07)
      <i>Background</i> - Population mean GFR is lower in older age, but it is unknown whether healthy aging is associated with preserved rather than lower GFR in some individuals.<br><br> <i>Methods</i> - We investigated the cross-sectional association between measured GFR, age, and health in persons aged 50–97 years in the general population through a meta-analysis of iohexol clearance measurements ...

    • Impaired Fasting Glucose Is Associated With Renal Hyperfiltration in the General Population 

      Melsom, Toralf; Mathisen, Ulla Dorte; Ingebretsen, Ole C; Jenssen, Trond Geir; Njølstad, Inger; Solbu, Marit Dahl; Toft, Ingrid; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Increased glomerular filtration rate (GFR), also called hyperfiltration, is a proposed mechanism for renal injury in diabetes. The causes of hyperfiltration in individuals without diabetes are largely unknown, including the possible role of borderline hyperglycemia. We assessed whether impaired fasting glucose (IFG; 5.6–6.9 mmol/L), elevated HbA1c, or hyperinsulinemia are associated with hyperfiltration ...