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Association of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Population

Permanent lenke
https://hdl.handle.net/10037/22499
DOI
https://doi.org/10.1016/j.ekir.2021.05.007
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article.pdf (798.1Kb)
Publisert versjon (PDF)
Dato
2021-05-18
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Melsom, Toralf; Norvik, Jon Viljar; Enoksen, Inger Therese; Stefansson, Vidar Tor Nyborg; Rismo, Renathe; Jenssen, Trond; Solbu, Marit Dahl; Eriksen, Bjørn Odvar
Sammendrag
Introduction - Although lower high-density lipoprotein cholesterol (HDL-C) levels are considered a risk factor for cardiovascular disease (CVD), experimental evidence suggest that aging, inflammation, and oxidative stress may remodel HDL-C, leading to dysfunctional HDL-C. Population studies on HDL-C and loss of the glomerular filtration rate (GFR) reported inconsistent results, but they used inaccurate estimates of the GFR and may have been confounded by comorbidity.

Methods - We investigated the association of HDL-C levels with risk of GFR loss in a general population cohort; the participants were aged 50–62 years and did not have diabetes, CVD, or chronic kidney disease (CKD) at baseline. The GFR was measured using iohexol-clearance at baseline (n=1627) and at the follow-up (n=1324) after a median of 5.6 years. We also investigated any possible effect modification by low-grade inflammation, physical activity, and sex.

Results - Higher HDL-C levels were associated with steeper GFR decline rates and increased risk of rapid GFR decline (>3 ml/min per 1.73 m2 per year) in multivariable adjusted linear mixed models and logistic regression (–0.64 ml/min per 1.73 m2 per year [95% CI –0.99, –0.29; P < 0.001] and odds ratio 2.7 [95% CI 1.4, 5.2; P < 0.001] per doubling in HDL-C). Effect modifications indicated a stronger association between high HDL-C and GFR loss in physically inactive persons, those with low-grade inflammation, and men.

Conclusion - Higher HDL-C levels were independently associated with accelerated GFR loss in a general middle-aged nondiabetic population.
Forlag
International Society of Nephrology
Elsevier
Sitering
Melsom, Norvik, Enoksen, Stefansson, Rismo, Jenssen, Solbu, Eriksen. Association of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Population. Kidney International Reports. 2021:1-11
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  • Artikler, rapporter og annet (klinisk medisin) [1974]
Copyright 2021 The Author(s)

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