ub.xmlui.mirage2.page-structure.muninLogoub.xmlui.mirage2.page-structure.openResearchArchiveLogo
    • EnglishEnglish
    • norsknorsk
  • Velg spraakEnglish 
    • EnglishEnglish
    • norsknorsk
  • Administration/UB
View Item 
  •   Home
  • Det helsevitenskapelige fakultet
  • Institutt for klinisk medisin
  • Artikler, rapporter og annet (klinisk medisin)
  • View Item
  •   Home
  • Det helsevitenskapelige fakultet
  • Institutt for klinisk medisin
  • Artikler, rapporter og annet (klinisk medisin)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study

Permanent link
https://hdl.handle.net/10037/10163
DOI
https://doi.org/10.1186/s12882-016-0386-4
Thumbnail
View/Open
article.pdf (910.3Kb)
Publisher's version (PDF)
Date
2016-11-10
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Stefansson, Vidar Tor Nyborg; Schei, Jørgen; Jenssen, Trond Geir; Melsom, Toralf; Eriksen, Bjørn Odvar
Abstract

Background - Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity is associated with hyperfiltration in the non-diabetic general population, remains unresolved due to a lack of consensus regarding the definition of hyperfiltration and the limited precision of high-range GFR estimations with creatinine and/or cystatin C.

Methods - 1555 middle-aged participants without diabetes, renal or cardiovascular disease were enrolled from the general population in the Renal Iohexol Clearance Survey from the 6th Tromsø Study (RENIS-T6) between 2007 and 2009. Obesity was assessed using the body mass index (BMI), waist circumference (WC) and the waist-hip ratio (WHR). GFR was measured by iohexol clearance. Dichotomous variables for hyperfiltration were based on two alternative definitions using unadjusted GFR (mL/min) above the 90th percentile. The 90th percentile was age-, sex- and height-specific in one definition and age-, sex-, height- and weight-specific in the other.

Results - In multivariable adjusted logistic regression models, only WHR was consistently associated with hyperfiltration based on both definitions. For the definition based on the age-, sex-, height- and weight-specific 90th percentile, the association with the WHR (odds ratios (95 % confidence intervals)) for hyperfiltration was 1.48 (1.08–2.02) per 0.10 WHR increase.

Conclusions - Central obesity is associated with hyperfiltration in the general population. The WHR may serve as a better indicator of the renal effects of obesity than BMI or WC.

Description
Source at https://doi.org/10.1186/s12882-016-0386-4.
Is part of
Stefansson, V.T.R. (2019). Obesity, renal hyperfiltration and glomerular filtration rate decline in the general population. (Doctoral thesis). https://hdl.handle.net/10037/15611.
Publisher
BioMed Central
Citation
Stefansson, V.T.N., Schei, J., Jenssen, T.G., Melsom, T. & Eriksen, B.O. (2016). Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study. BMC Nephrology, 17, 172. https://doi.org/10.1186/s12882-016-0386-4
Metadata
Show full item record
Collections
  • Artikler, rapporter og annet (klinisk medisin) [1974]

Browse

Browse all of MuninCommunities & CollectionsAuthor listTitlesBy Issue DateBrowse this CollectionAuthor listTitlesBy Issue Date
Login

Statistics

View Usage Statistics
UiT

Munin is powered by DSpace

UiT The Arctic University of Norway
The University Library
uit.no/ub - munin@ub.uit.no

Accessibility statement (Norwegian only)