dc.contributor.author | Stefansson, Vidar Tor Nyborg | |
dc.contributor.author | Schei, Jørgen | |
dc.contributor.author | Jenssen, Trond Geir | |
dc.contributor.author | Melsom, Toralf | |
dc.contributor.author | Eriksen, Bjørn Odvar | |
dc.date.accessioned | 2017-01-16T14:08:39Z | |
dc.date.available | 2017-01-16T14:08:39Z | |
dc.date.issued | 2016-11-10 | |
dc.description.abstract | <b>Background:</b> Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally
high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease.
Whether obesity is associated with hyperfiltration in the non-diabetic general population, remains unresolved due
to a lack of consensus regarding the definition of hyperfiltration and the limited precision of high-range GFR
estimations with creatinine and/or cystatin C.<br>
<b>Methods:</b> 1555 middle-aged participants without diabetes, renal or cardiovascular disease were enrolled from the
general population in the Renal Iohexol Clearance Survey from the 6th Tromsø Study (RENIS-T6) between 2007 and
2009. Obesity was assessed using the body mass index (BMI), waist circumference (WC) and the waist-hip ratio (WHR).
GFR was measured by iohexol clearance. Dichotomous variables for hyperfiltration were based on two alternative
definitions using unadjusted GFR (mL/min) above the 90th percentile. The 90th percentile was age-, sex- and heightspecific
in one definition and age-, sex-, height- and weight-specific in the other.<br>
<b>Results:</b> In multivariable adjusted logistic regression models, only WHR was consistently associated with hyperfiltration
based on both definitions. For the definition based on the age-, sex-, height- and weight-specific 90th percentile,
the association with the WHR (odds ratios (95 % confidence intervals)) for hyperfiltration was 1.48 (1.08–2.02) per 0.10
WHR increase.<br>
<b>Conclusions:</b> Central obesity is associated with hyperfiltration in the general population. The WHR may serve as a
better indicator of the renal effects of obesity than BMI or WC. | en_US |
dc.description | © The Author(s). 2016 Open Access This article is distributed under the terms of the <a href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0
International License</a>, which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. <a href="http://creativecommons.org/publicdomain/zero/1.0/">The Creative Commons Public Domain Dedication waiver</a> applies to the data made available in this article, unless otherwise stated. | en_US |
dc.identifier.citation | BMC Nephrology (2016) 17:172 | en_US |
dc.identifier.issn | 1471-2369 | |
dc.identifier.other | FRIDAID 1415017 | |
dc.identifier.other | 10.1186/s12882-016-0386-4 | |
dc.identifier.uri | https://hdl.handle.net/10037/10163 | |
dc.language.iso | eng | en_US |
dc.publisher | BioMed Central | en_US |
dc.rights.accessRights | openAccess | en_US |
dc.subject | Body mass index | en_US |
dc.subject | Chronic kidney disease | en_US |
dc.subject | Glomerular filtration rate | en_US |
dc.subject | Glomerular hyperfiltration | en_US |
dc.subject | Waist circumference | en_US |
dc.subject | Waist-hip ratio | en_US |
dc.subject | VDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803 | en_US |
dc.subject | VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801 | en_US |
dc.subject | VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801 | en_US |
dc.title | Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |