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dc.contributor.authorStefansson, Vidar Tor Nyborg
dc.contributor.authorSchei, Jørgen
dc.contributor.authorJenssen, Trond Geir
dc.contributor.authorMelsom, Toralf
dc.contributor.authorEriksen, Bjørn Odvar
dc.date.accessioned2017-01-16T14:08:39Z
dc.date.available2017-01-16T14:08:39Z
dc.date.issued2016-11-10
dc.description.abstract<b>Background:</b> Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity is associated with hyperfiltration in the non-diabetic general population, remains unresolved due to a lack of consensus regarding the definition of hyperfiltration and the limited precision of high-range GFR estimations with creatinine and/or cystatin C.<br> <b>Methods:</b> 1555 middle-aged participants without diabetes, renal or cardiovascular disease were enrolled from the general population in the Renal Iohexol Clearance Survey from the 6th Tromsø Study (RENIS-T6) between 2007 and 2009. Obesity was assessed using the body mass index (BMI), waist circumference (WC) and the waist-hip ratio (WHR). GFR was measured by iohexol clearance. Dichotomous variables for hyperfiltration were based on two alternative definitions using unadjusted GFR (mL/min) above the 90th percentile. The 90th percentile was age-, sex- and heightspecific in one definition and age-, sex-, height- and weight-specific in the other.<br> <b>Results:</b> In multivariable adjusted logistic regression models, only WHR was consistently associated with hyperfiltration based on both definitions. For the definition based on the age-, sex-, height- and weight-specific 90th percentile, the association with the WHR (odds ratios (95 % confidence intervals)) for hyperfiltration was 1.48 (1.08–2.02) per 0.10 WHR increase.<br> <b>Conclusions:</b> Central obesity is associated with hyperfiltration in the general population. The WHR may serve as a better indicator of the renal effects of obesity than BMI or WC.en_US
dc.description© The Author(s). 2016 Open Access This article is distributed under the terms of the <a href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</a>, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. <a href="http://creativecommons.org/publicdomain/zero/1.0/">The Creative Commons Public Domain Dedication waiver</a> applies to the data made available in this article, unless otherwise stated.en_US
dc.identifier.citationBMC Nephrology (2016) 17:172en_US
dc.identifier.issn1471-2369
dc.identifier.otherFRIDAID 1415017
dc.identifier.other10.1186/s12882-016-0386-4
dc.identifier.urihttps://hdl.handle.net/10037/10163
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.rights.accessRightsopenAccessen_US
dc.subjectBody mass indexen_US
dc.subjectChronic kidney diseaseen_US
dc.subjectGlomerular filtration rateen_US
dc.subjectGlomerular hyperfiltrationen_US
dc.subjectWaist circumferenceen_US
dc.subjectWaist-hip ratioen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleCentral obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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