Abnormal increases in nucleolar size and number caused by dysregulation of ribosome biogenesis has emerged as a hallmark in the majority of spontaneous cancers. The observed ribosome hyperactivity can be directly induced by the MYC transcription factors controlling the expression of RNA and protein components of the ribosome. Neuroblastoma, a highly malignant childhood tumor of the sympathetic nervous ...

Fish or crustaceans stuck in the fishing gear meshes can lead to operational problems in some fisheries and thereby affect the economic gain. However, mesh sticking probability has never been formally quantified as a part of the estimation of fishing gear size selectivity. Therefore, this study developed a size selection model and estimation procedure that, besides the size dependent retention and ...

This study reports the isolation of two novel cysteine-rich antibacterial peptides, turgencin A and turgencin B, along with their oxidized derivatives, from the Arctic marine colonial ascidian <i>Synoicum turgens</i>. The peptides are post-translationally modified, containing six cysteines with an unusual disulfide connectivity of Cys¹-Cys⁶, Cys²-Cys⁵, and ...

Den matematiske samtalen i tradisjonelle og virtuelle klasserom er en kvalitativ studie hvor vi ser på lærernes bruk av samtaletrekk som redskap for å skape ei aktiv tilnærming til matematikkfaget i de to ulike klasseromsformene. Det teoretiske fundamentet for studien og datainnsamlingen tar utgangspunkt i Chapin et al. (2009) sine samtaletrekk (gjenta, repetere, resonnere, tilføye, vente, snu ...

Multidrug-resistant (MDR) bacteria, including Escherichia coli, producing extended-spectrum β-lactamase (ESBL), AmpC or carbapenemases, are acknowledged among the most significant global health threats. Growing rates of MDR E.coli can lead to an increase in the use of reserve antimicrobials. Re-introducing “old antimicrobials” could offer a timely solution. This work aimed at evaluating the role of ...

I denne artikkelen diskuterer vi tilpassing av familieråd til ein samisk kontekst. Studien bygger på intervju med sosialarbeidarar i samiske område. Vi finn at familierådsmodellen sitt teoretiske grunnlag bør tematisere samisk storfamilie, samiske kommunikasjonsformer, samiske ideal for barnet si deltaking og familierådskoordinator si lokale tilknyting. Det teoretiske grunnlaget må diskutere at ...

Prefaktiske tanker – tanker om konsekvenser av tenkte handlinger før de utføres – kan være gunstig for å forstå hvordan fremtidige mål kan oppnås. (Epstude, Scholl & Roese, 2016), mens kontrafaktisk tanker – tanker om hva som alternativt kunne skjedd – er funksjonell ved å hjelpe individet med atferdsregulering (Epstude & Roese, 2008). Denne studien undersøker sammenhengen mellom studenters prefaktiske- ...

To understand and manipulate the interactions between plants and microorganisms, sterile seeds are a necessity. The seed microbiome (inside and surface microorganisms) is unknown for most plant species and seed-borne microorganisms can persist and transfer to the seedling and rhizosphere, thereby obscuring the effects that purposely introduced microorganisms have on plants. This necessitates that ...

The human PRKAR1A gene is a 381- amino acid protein encoding the regulatory subunit (RIα) of the cAMP dependent Protein Kinase A (PKA). The main function of PRKAR1A is to regulate the catalytic activity of PKA. PRKAR1A is shown to regulate autophagy via association with mTOR kinase and colocalization with the autophagy marker proteins LC3B, Rab7 and Rab9. Contradictory findings regarding the ...

Lumpfish (<i>Cyclopterus lumpus</i> L.) in Norway is currently produced in traditional flow-through systems (FTS). Hatcheries frequently show signs of bacterial infections, unstable microbial communities in the rearing water and varying mortality. Recirculating aquaculture systems (RAS) is proposed to create stable and healthy microbial environments, with less probabilities for blooming of opportunistic ...