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norskMunin: Recent submissions
Now showing items 20221-20240 of 37171
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Development and validation of circulating CA125 prediction models in postmenopausal women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-26)<i>Background</i> - Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal characteristics that influence CA125 could be used to improve its performance as screening biomarker.<p><p> <i>Methods</i> - We developed and validated ... -
SQSTM-1/p62 potentiates HTLV-1 Tax-mediated NF-κB activation through its ubiquitin binding function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-05)The NF-κB pathway is constitutively activated in adult T cell leukemia, an aggressive malignancy caused by Human T Leukemia Virus type 1 (HTLV-1). The viral oncoprotein Tax triggers this constitutive activation by interacting with the ubiquitin-rich IKK complex. We previously demonstrated that Optineurin and TAX1BP1, two members of the ubiquitin-binding, Sequestosome-1 (SQSTM-1/p62)-like selective ... -
Children's Right to Respect for Their Human Dignity
(Chapter; Bokkapittel, 2019) -
Children’s Constitutional Rights in the Nordic Countries: Do Constitutional Rights Matter?
(Chapter; Bokkapittel, 2019-12-02)This chapter consists of a comparative analyses of children’s constitutional rights in the Nordic countries. First, we analyse children’s constitutional rights in general in the Nordic countries to assess if and how a Constitution is in line with the child’s rights approach of the Convention on the Rights of the Child (crc). We build on a model developed by Conor O’Mahony that measures the protection ... -
Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone: A nation-wide register-based controlled before-after study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-21)In this controlled before-after study based on data from the Norwegian Prescription Database, we examine whether starting off-label use of Low Dose Naltrexone (LDN) is followed by changes in the consumption of psychotropic medicines including antiepileptics. Patients that collected LDN for the first time in 2013 (N = 11247) were included and stratified into three groups based on LDN exposure. We ... -
Towards Rational Computational Engineering of Psychrophilic Enzymes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-16)Cold-adapted enzymes from psychrophilic species achieve their high catalytic efficiency at low temperature by a different partitioning of the activation free energy into its enthalpic and entropic components, compared to orthologous mesophilic enzymes. Their lower activation enthalpy, partly compensated by an increased entropic penalty, has been suggested to originate from changes in flexibility of ... -
Marine fish traits follow fast-slow continuum across oceans
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-29)A fundamental challenge in ecology is to understand why species are found where they are and predict where they are likely to occur in the future. Trait-based approaches may provide such understanding, because it is the traits and adaptations of species that determine which environments they can inhabit. It is therefore important to identify key traits that determine species distributions and ... -
Efficient live and on-demand tiled HEVC 360 VR video streaming
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019)360∘ panorama video displayed through Virtual Reality (VR) glasses or large screens offers immersive user experiences, but as such technology becomes commonplace, the need for efficient streaming methods of such high-bitrate videos arises. In this respect, the attention that 360∘ panorama video has received lately is huge. Many methods have already been proposed, and in this paper, we shed more light ... -
Biphasic release of the alarmin high mobility group box 1 protein early after trauma predicts poor clinical outcome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08)<i>Objective</i>: The causal role of the prototype alarmin high mobility group box 1 protein (HMGB1) in systemic inflammation and remote organ injury after trauma and shock is established in animal models but not in humans. Our aim was therefore to determine HMGB1 concentration kinetics with high time resolution during the first hours after trauma in individual patients, and investigate the ... -
Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)<i>Background</i> - The relevance of blood lipid concentrations to long-term incidence of cardiovascular disease and the relevance of lipid-lowering therapy for cardiovascular disease outcomes is unclear. We investigated the cardiovascular disease risk associated with the full spectrum of bloodstream non-HDL cholesterol concentrations. We also created an easy-to-use tool to estimate the long-term ... -
Continuous hemodynamic monitoring in an intact rat model of simulated diving
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-13)Cardiovascular risk is elevated in divers, but detailed information of cardiac function during diving is missing. The aim of this study was to apply an intact rat model with continuous monitoring of cardiac left ventricular (LV) function in a simulated diving experiment. Thirteen rats were inserted with a LV pressure–volume catheter and a pressure transducer in the femoral artery to measure hemodynamic ... -
Role of CALCOCO1 in scaling down endoplasmic reticulum and Golgi by autophagy
(Doctoral thesis; Doktorgradsavhandling, 2020-02-20)Endoplasmic reticulum (ER) and Golgi apparatus are key organelles in the synthesis, modification and trafficking of proteins in eukaryotic cells. In response to stress stimuli such as nutrients deprivation, accumulation of misfolded proteins or exposure to chemicals, the ER increases in size through increased synthesis of its components to counteract the stress. Similarly, Golgi response to stress ... -
Symposium on "parental education" at the ICCH17
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-22)This symposium report provides a brief overview of the six programmes and studies on parental education and maternal health services within the circumpolar region presented in the symposium “parental education” at the 17th International Congress of Circumpolar Health in Copenhagen, Denmark, August 2018. -
Increased risk of fatal paediatric injuries in rural Northern Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-09)<i>Background</i> - Finnmark, Northern Norway, had a mortality rate for paediatric injury in 1998‐2007 that was more than twice the national average. We investigated whether this rate had decreased in 2008‐2015 after improvements in emergency care. We also compared the mortality rate to rates of non‐fatal injury and trauma team activation both regionally and in Norway.<p> <p><i>Methods</i> - The ... -
Pulmonary manifestations and progression of lung disease in juvenile-onset mixed connective tissue disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-01)<i>Objective</i> - To assess the occurrence and extent of interstitial lung disease (ILD) in patients with juvenile mixed connective tissue disease (JMCTD), compare pulmonary function in patients and matched controls, study associations between ILD and disease-related variables, and examine progression of pulmonary manifestations over time.<p> <p><i>Methods</i> - A cohort of 52 patients with JMCTD ... -
Assessing winter pasture quality in Sunnfjord wild reindeer area
(Master thesis; Mastergradsoppgave, 2019-11-30)Winter pastures are bottlenecks for population trends for wild reindeer, and the quality and availability are important parameters when managing populations. Sunnfjord, considered on of the smallest wild reindeer districts in Norway, have never had a comprehensive evaluation of accessible winter pasture within. The aim of study is to assess the quality of winter forage in all tree sub- areas within ... -
Justice for the LGBTQ+ community through Celebrating Pride. An examination of justice for sexual minorities in the light of recognition and redisribution, as presented by Axel Honneth and Nancy Fraser.
(Master thesis; Mastergradsoppgave, 2019-11-18)The LGBTQ+ community has over the past fifty years gone from being a severely oppressed group of people, where most people lived closeted lives, to become a well known minority group that many people associate with celebration, bravery and pride. This is not to say that the circumstances have completely changed for the LGBTQ+ community. They are still subjected to a high level of threat when it comes ... -
Timing of HPV16-E6 antibody seroconversion before OPSCC: Findings from the HPVC3 consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-06)<i>Background</i> - Human papillomavirus type 16 (HPV16)-E6 antibodies are detectable in peripheral blood before diagnosis in the majority of HPV16-driven oropharyngeal squamous cell carcinoma (OPSCC), but the timing of seroconversion is unknown.<p> <p><i>Patients and methods</i> - We formed the HPV Cancer Cohort Consortium which comprises nine population cohorts from Europe, North America and ... -
Vitamin D status in a multi-ethnic population of northern Norway: The SAMINOR 2 Clinical Survey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-15)<i>Objective</i> - To investigate serum 25-hydroxyvitamin D (S-25(OH)D) concentration in a multi-ethnic population of northern Norway and determine predictors of S-25(OH)D, including Sami ethnicity.<p> <p><i>Design</i> - Cross-sectional data from the second survey of the Population-based Study on Health and Living Conditions in Regions with Sami and Norwegian Populations (the SAMINOR 2 Clinical ... -
No ethnic disparities in nutritional adequacy between the Indigenous Sami and the non-Sami population living in rural Northern Norway—the SAMINOR 2 Clinical Survey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-28)The diet of the Indigenous Sami people has become more Westernized. The lack of population-based data on nutrient intake and nutritional adequacy, in combination with a high prevalence of obesity/metabolic syndrome among Sami, was the rationale behind the present study. We hypothesized that differences in nutrient intake between Sami and non-Sami populations may still exist but that these differences ...
