Now showing items 25221-25240 of 37154

    • PEGylated liposomes for topical vaginal therapy improve delivery of interferon alpha 

      Jøraholmen, May Wenche; Basnet, Purusotam; Acharya, Ganesh; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-11)
      Recent studies regarding mucosal drug delivery indicate that nanosystems with surface-available polyethylene glycol (PEG) are able to penetrate mucus barrier, assure closer contact with the epithelium, and improve drug delivery to vagina. In the present work, we developed the mucus-penetrating PEGylated liposomes containing interferon alpha-2b (IFN α-2b), destined to provide localized therapy for ...
    • Quality of medication information in discharge summaries from hospitals: an audit of electronic patient records 

      Garcia, Beate Hennie; Djønne, Berit K; Skjold, Frode; Mellingen, Ellen Marie; Aag, Trine Iversen (Journal article; Tidsskriftartikkel, 2017-11-03)
      Background: Low quality of medication information in discharge summaries from hospitals may jeopardize optimal therapy and put the patient at risk for medication errors and adverse drug events. <br> <p> Objective: To audit the quality of medication information in discharge summaries and explore factors associated with the quality. Setting Helgelandssykehuset Mo i Rana, a rural hospital in central ...
    • Sea ice local surface topography from single-pass satellite InSAR measurements: A feasibility study 

      Dierking, Wolfgang Fritz Otto; Lang, Oliver; Busche, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-29)
      Quantitative parameters characterizing the sea ice surface topography are needed in geophysical investigations such as studies on atmosphere–ice interactions or sea ice mechanics. Recently, the use of space-borne single-pass interferometric synthetic aperture radar (InSAR) for retrieving the ice surface topography has attracted notice among geophysicists. In this paper the potential of InSAR ...
    • Safety and efficiency of a new generic package labelling: A before and after study in a simulated setting 

      Garcia, Beate Hennie; Elenjord, Renate; Bjørnstad, Camilla Hilda; Halvorsen, Kjell H.; Hortemo, Sigurd; Madsen, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-20)
      Background: Medication errors are frequent and may cause harm to patients and increase healthcare expenses. <p> Aim: To explore whether a new labelling influences time and errors when preparing medications in accordance with medication charts in an experimental setting. <p> Method: We carried out an uncontrolled before and after study with 3 months inbetween experiments. Phase I used original ...
    • Synthesis of a novel tripeptidomimetic scaffold and biological evaluation for CXC chemokine receptor 4 (CXCR4) antagonism 

      Baumann, Markus; Nome, Lina Marie; Zachariassen, Zack Georg; Karlshøj, Stepfanie; Fossen, Torgils; Rosenkilde, Mette M.; Våbenø, Jon; Haug, Bengt Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-17)
      We here report the preparation of a new 2,6,8-trisubstituted bicyclic tripeptidomimetic scaffold through TFA-mediated cyclization of a linear precursor containing three side chains. The introduction of a triphenylmethyl-protected thiol into carboxylic acid containing building blocks through sulfa Michael additions onto α,β-unsaturated hexafluoroisopropyl esters is described. The stereoselectivity ...
    • Parent participation in alcohol prevention: Evaluation of an alcohol prevention programme 

      Adolfsen, Frode; Strøm, Henriette Kyrrestad; Martinussen, Monica; Handegård, Bjørn Helge; Natvig, Henrik; Eisemann, Martin; Koposov, Roman A (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-25)
      Aim: <br>The main purpose of this study was to evaluate the effectiveness of the parental part of the Norwegian Unge & Rus (Youth and Alcohol) programme. The intervention was aimed at changing parents’ rules and attitudes towards adolescent alcohol use, and their ability to talk with their adolescents about alcohol, as well as improving parents’ relationships with and knowledge about their ...
    • Probability revision in general practice: the cases of occult blood in stool in patients with indigestion, and daily smoking in patients who cough 

      Holtedahl, Knut A. (Journal article; Tidsskriftartikkel; Peer reviewed, 1990)
      Prior calculation of the sex- and age-distributed positive predictive value (PPV) of a symptom in relation to a disease forms the basis for probability revision based on new information about signals observed during the medical encounter: a symptom, a sign, a piece of information based on the medical history, a laboratory test. Probability revision requires estimates of sensitivity and specificity ...
    • Linking brain networks and behavioral variability to different types of mind-wandering 

      Csifcsak, Gabor; Mittner, Matthias (Others; Andre, 2017-07-13)
    • Molecular analyses reveal high cryptic diversity of trematodes in a sub-Arctic lake 

      Soldánová, Miroslava; Georgieva, Simona; Roháčová, Jana; Knudsen, Rune; Kuhn, Jesper A.; Henriksen, Eirik Haugstvedt; Siwertsson, Anna; Shaw, Jenny C.; Kuris, Armand M.; Amundsen, Per-Arne; Scholz, Tomas; Lafferty, Kevin D.; Kostadinova, Aneta (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-14)
      To identify trematode diversity and life-cycles in the sub-Arctic Lake Takvatn, Norway, we characterised 120 trematode isolates from mollusc first intermediate hosts, metacercariae from second intermediate host fishes and invertebrates, and adults from fish and invertebrate definitive hosts, using molecular techniques. Phylogenies based on nuclear and/or mtDNA revealed high species richness (24 ...
    • Trust versus perceived quality in scholarly publishing: A personality-attitude-intention approach 

      Moksness, Lars; Olsen, Svein Ottar (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-01)
      Digital academic journals serve as the main dissemination method for peer-reviewed research articles. These journals can be divided into two main categories: open access (OA) and non– open access (non-OA) journals. OA literature is defined by Suber as “digital, online, free of charge, and free of most copyright and licensing restrictions.” The reasons why no-cost OA adoption is slow-going ...
    • Comorbidity and outcomes of concurrent chemo- and radiotherapy in limited disease small cell lung cancer 

      Halvorsen, Tarje Onsøien; Sundstrøm, Stein Harald; Fløtten, Øystein; Brustugun, Odd Terje; Brunsvig, Paal Fr.; Aasebø, Ulf; Bremnes, Roy M.; Kaasa, Stein; Grønberg, Bjørn Henning (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-23)
      <b>Background:</b> Many patients with limited disease small cell lung cancer (LD SCLC) suffer from comorbidity. Not all patients with comorbidity are offered standard treatment, though there is little evidence for such a policy. The aim of this study was to investigate whether patients with comorbidity had inferior outcomes in a LD SCLC cohort. <br><b>Material and methods:</b> We analyzed patients ...
    • Molecular signatures reflecting microenvironmental metabolism and chemotherapy-induced immunogenic cell death in colorectal liver metastases 

      Østrup, Olga; Dagenborg, Vegar Johansen; Rødland, Einar Andreas; Skarpeteig, Veronica; Silwal-Pandit, Laxmi; Grzyb, Krzysztof; Berstad, Audun Elnæs; Fretland, Åsmund Avdem; Mælandsmo, Gunhild; Børresen-Dale, Anne-Lise; Ree, Anne Hansen; Edwin, Bjørn; Nygaard, Vigdis; Flatmark, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-18)
      Background: Metastatic colorectal cancer (CRC) is associated with highly variable clinical outcome and response to therapy. The recently identified consensus molecular subtypes (CMS1-4) have prognostic and therapeutic implications in primary CRC, but whether these subtypes are valid for metastatic disease is unclear. We performed multi-level analyses of resectable CRC liver metastases (CLM) to ...
    • Going skin deep: a direct comparison of penetration potential of lipid-based nanovesicles on the isolated perfused human skin flap model 

      Ternullo, Selenia; de Weerd, Louis; Holsæter, Ann Mari; Flaten, Gøril Eide; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel, 2017-09-12)
      Phospholipid-based nanocarriers are attractive drug carriers for improved local skin therapy. In the present study, the recently developed isolated perfused human skin flap (IPHSF) model was used to directly compare the skin penetration enhancing potential of the three commonly used nanocarriers, namely conventional liposomes (CLs), deformable liposomes (DLs) and solid lipid nanoparticles (SLNs). ...
    • Sprayable Carbopol hydrogel with soluble beta-1,3/1,6-glucan as an active ingredient for wound healing – Development and in-vivo evaluation 

      Grip, Jostein; Engstad, Rolf Einar; Skjærveland, Ingrid; Skalko-Basnet, Natasa; Holsæter, Ann Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-21)
      Chronic wounds represent a significant health problem worldwide. There is a need for advanced- and cost-efficient wound healing products able to increase patient comfort and reduce the healing time. The aim of this study was to develop a sprayable hydrogel dressing with beta-glucan (βG) as the active ingredient, targeting future application in the treatment of both chronic and burn wounds. The βG ...
    • Molecular transfer to Atlantic salmon ovulated eggs using liposomes 

      Kumari, Jaya; Flaten, Gøril Eide; Skalko-Basnet, Natasa; Tveiten, Helge (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-15)
      The delivery of exogenous biomolecules into teleost eggs is currently mostly relying on the manual microinjection methods, which, due to their high costs and low throughput, are not economically feasible for large-scale aquaculture applications. The main objective of this study was to develop a convenient, simple immersion delivery model for unfertilized Atlantic salmon (Salmo salar L.) eggs using ...
    • How robust are in situ observations for validating satellite-derived albedo over the dark zone of the Greenland Ice Sheet? 

      Ryan, J.C.; Hubbard, Alun Lloyd; Irvine-Fynn, T.; Doyle, S.H.; Cook, J.M.; Stibal, Marek; Box, J.E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-17)
      Calibration and validation of satellite‐derived ice sheet albedo data require high‐quality, in situ measurements commonly acquired by up and down facing pyranometers mounted on automated weather stations (AWS). However, direct comparison between ground and satellite‐derived albedo can only be justified when the measured surface is homogeneous at the length‐scale of both satellite pixel and in situ ...
    • Metabolic reprogramming supports the invasive phenotype in malignant melanoma 

      Bettum, Ingrid Johanne; Gorad, Saurabh Sayajirao; Barkovskaya, Anna; Pettersen, Solveig; Moestue, Siver Andreas; Vasiliauskaite, Kotryna; Tenstad, Ellen; Øyjord, Tove Ragnhild; Risa, Øystein; Nygaard, Vigdis; Mælandsmo, Gunhild; Prasmickaite, Lina (Journal article; Tidsskriftartikkel, 2015)
      Invasiveness is a hallmark of aggressive cancer like malignant melanoma, and factors involved in acquisition or maintenance of an invasive phenotype are attractive targets for therapy. We investigated melanoma phenotype modulation induced by the metastasis-promoting microenvironmental protein S100A4, focusing on the relationship between enhanced cellular motility, dedifferentiation and metabolic ...
    • Sea-ice dynamics in an Arctic coastal polynya during the past 6500 years 

      Knies, Jochen; Pathirana, Irene Dorothea; Cabedo-Sanz, Patricia; Banica, Ana; Fabian, Karl; Rasmussen, Tine Lander; Forwick, Matthias; Belt, Simon T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-23)
      The production of high-salinity brines during sea-ice freezing in circum-arctic coastal polynyas is thought to be part of northern deep water formation as it supplies additional dense waters to the Atlantic meridional overturning circulation system. To better predict the effect of possible future summer ice-free conditions in the Arctic Ocean on global climate, it is important to improve our ...
    • Structural insight into a CE15 esterase from the marine bacterial metagenome 

      De Santi, Concetta; Gani, Osman A. B. S. M.; Helland, Ronny; Williamson, Adele Kim (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-08)
      The family 15 carbohydrate esterase (CE15) MZ0003, which derives from a marine Arctic metagenome, has a broader substrate scope than other members of this family. Here we report the crystal structure of MZ0003, which reveals that residues comprising the catalytic triad differ from previously-characterized fungal homologs, and resolves three large loop regions that are unique to this bacterial ...
    • Svøpt i myra - Synspunkter på Skjoldehamnfunnets etniske og kulturelle tilknytning 

      Svestad, Asgeir (Journal article; Tidsskriftartikkel; Peer reviewed, 2017)
      In 1936 an extraordinary find of a clothed skeleton wrapped in a blanket and covered with birch bark appeared in a bog at Skjoldehamn on Andøya Island. The wrapped body was laid on a reindeer pelt, which in turn was placed on sticks of birch. The grave dates to the 11th century, probably the later half. Compared with relevant Norse, Sámi, and Christian graves and burial customs, the Skjoldehamn grave ...