Antibiotic-resistant pathogens are a major public health threat. A deeper understanding of how an antibiotic’s mechanism of action influences the emergence of resistance would aid in the design of new drugs and help to preserve the effectiveness of existing ones. To this end, we developed a model that links bacterial population dynamics with antibiotic-target binding kinetics. Our approach allows ...

Otoliths (ear-stones) in the inner ears of vertebrates containing visible year zones are used extensively to determine fish age. Analysis of otoliths is a time-consuming and difficult task that requires the education of human experts. Human age estimates are inconsistent, as several readings by the same human expert might result in different ages assigned to the same otolith, in addition to an ...

Arctic ecosystems are changing dramatically with warmer and wetter conditions resulting in complex interactions between herbivores and their forage. We investigated how Svalbard reindeer (Rangifer tarandus platyrhynchus) modify their late winter diets in response to long-term trends and interannual variation in forage availability and accessibility. By reconstructing their diets and foraging ...

Background and aims: The study aimed to identify yet unknown and uncharacterized long non-coding RNAs (lncRNAs) in treatment-naïve ulcerative colitis (UC), and to define their possible roles in UC pathogenesis. For that purpose, accurate quantification methods for lncRNA transcript detection, multiple and “stringent” strategies were applied. New insights in the regulation of functional genes and ...

Idiopyrgus is a relict genus of freshwater snails from Brazil traditionally classified in the family Pomatiopsidae. Herein, we use molecular data from newly acquired specimens to test that classification through Bayesian inference phylogenetic analysis. We conclude that Idiopyrgus belongs in the Gondwanan family Tomichiidae, together with the African genus Tomichia and the Australian genus Coxiella. ...

A scientific theory is judged by its ability to provide a principled explanation of less straightforward facts that lie at the margins of the data normally discussed and captured by other theories. To the extent that those data naturally follow from the new proposal, that theory is successfull in defining a new paradigm. Mixed Categories, by Irina Nikolaeva and Andrew Spencer, is an excellent example ...

To document energy savings from retrofitting a building, a reliable baseline model is needed. The development and implementation of the baseline model is an important step in the measurement and verification (M&V) process. Usually, an energy analyst enters the stage, collects data, do the estimation and delivers the baseline model. The modeling work of the energy analyst is done on either a proprietary ...

Over several decades, the consideration of future consequences (CFC) construct has been used to explain and predict health behaviors. However, the reported associations between CFC and health behaviors are relatively weak, leading to the low explanatory power of the models. Recent research suggests that CFC can be a domain-specific construct. In this study, we explored the psychometric properties ...

In this article, we explore the possibility of detecting polar lows in C-band synthetic aperture radar (SAR) images by means of deep learning. Specifically, we introduce a novel dataset consisting of Sentinel-1 images divided into two classes, representing the presence and absence of a maritime mesocyclone, respectively. The dataset is constructed using the ECMWF reanalysis version 5 (ERA5) dataset ...

The ability to track variation in climate is important for species to persist in a given environment. Lack of responses to both long-term changes and inter-annual variation in climate parameters can result in reduced fitness and population decline. Furthermore, migration strategy can influence the ability to track climatic variation due to the potential to use reliable environmental cues. Here, ...